Super Sloth is randomly encountered as an alternate version of Sloth, one of the Seven Deadly Sins and functions as a mini-boss.
- He will wander aimlessly around the room in which he is found. Contact with Super Sloth will deal damage.
- Every few seconds, regardless of Isaac's distance to Super Sloth, Super Sloth will do one of two things:
- Shoots 2 IpecacReplaces tears with explosive and poisoning projectiles fired in an arc from the mouth.-like shots towards Isaac, which deal a full heart of damage regardless of the chapter.
- Spawns 2 hostile Spiders.
- Super Sloth seems to look like a green tinted Gazing Globin with a large head. This may be done humorously to represent his sin, sloth (laziness).