Super Sloth is randomly encountered as an alternate version of Sloth, one of the Seven Deadly Sins and functions as a mini-boss.
- He will wander around the room in which he is found. Contact with Super Sloth will result in contact damage to Isaac.
- Every few seconds, regardless of Isaac's distance to Super Sloth, Super Sloth will do one of two things:
- Shoots 2 Ipecac-like shots towards Isaac, which deal a full heart of damage regardless of the chapter.
- Spawns 2 hostile Spiders.
- Super Sloth seems to look like a green-tinted Gazing Globin with a large head. This may be done humorously to represent his sin, sloth (laziness).