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Mom  Unlocks Mom Unlocks Mom  Unlocks
Added in  Afterbirth Added in Afterbirth †
The WombThe WombDefeat Mom for the 1st timeThe HarbingersThe HarbingersDefeat Mom for the 1st timeA Cube of MeatA Cube of MeatDefeat Mom for the 1st timeA HaloA HaloDefeat Mom using The BiblePuristPuristDefeat Mom for the first time XXXXXXXXLXXXXXXXXLDefeat Mom for the 1st timeSPEED!SPEED!Defeat Mom for the 1st timeHave a HeartHave a HeartDefeat Mom for the 1st timePRIDE DAY!PRIDE DAY!Defeat Mom for the 1st timeOnan's StreakOnan's StreakDefeat Mom for the 1st timeThe GuardianThe GuardianDefeat Mom for the 1st time Aprils foolAprils foolDefeat Mom for the 1st time


Mom's Heart  Unlocks Mom's Heart Unlocks Mom's Heart  Unlocks
Added in  Afterbirth Added in Afterbirth †
A NooseA NooseDefeat Mom's Heart 3 timesA QuarterA QuarterDefeat Mom's Heart 8 timesA Fetus in a JarA Fetus in a JarDefeat Mom's Heart 9 times??????Defeat Mom's Heart 10 timesEverything Is Terrible!!!Everything Is Terrible!!!Defeat Mom's Heart 5 timesIt Lives!It Lives!Defeat Mom's Heart 11 timesWire Coat HangerWire Coat HangerDefeat Mom's Heart 4 timesIpecacIpecacDefeat Mom's Heart 6 timesExperimental TreatmentExperimental TreatmentDefeat Mom's Heart 7 timesRubber CementRubber CementDefeat Mom's Heart 2 timesDarkness FallsDarkness FallsDefeat Mom's Heart 11 timesSolar SystemSolar SystemDefeat Mom's Heart 3 timesSuicide KingSuicide KingDefeat Mom's Heart 11 timesDemo ManDemo ManDefeat Mom's Heart 9 timesLost BabyLost BabyDefeat Mom's Heart on hard mode as IsaacCute BabyCute BabyDefeat Mom's Heart on hard mode as MagdaleneCrow BabyCrow BabyDefeat Mom's Heart on hard mode as EveShadow BabyShadow BabyDefeat Mom's Heart on hard mode as JudasGlass BabyGlass BabyDefeat Mom's Heart on hard mode as CainWrapped BabyWrapped BabyRemoved in Afterbirth † Defeat Mom's Heart on hard mode as Azazel
Added in Afterbirth † Defeat Mom's Heart on hard mode as Lazarus
Begotten BabyBegotten BabyRemoved in Afterbirth † Defeat Mom's Heart on hard mode as Lazarus
Added in Afterbirth † Defeat Mom's Heart on hard mode as Azazel
Dead BabyDead BabyDefeat Mom's Heart on hard mode as ???-0- Baby-0- BabyDefeat Mom's Heart on hard mode as The LostGlitch BabyGlitch BabyDefeat Mom's Heart on hard mode as EdenFighting BabyFighting BabyDefeat Mom's Heart on hard mode as Samson
Goat Head BabyGoat Head BabyDefeat Mom's Heart on hard mode as LilithBlue WombBlue WombDefeat Mom's Heart 10 timesSuper Greed BabySuper Greed BabyDefeat Mom's Heart on hard mode as KeeperBlue BomberBlue BomberDestroy 10 tinted rocks and defeat Mom's Heart 11 times Pokey MansPokey MansDefeat Mom's Heart 11 timesSmelterSmelterDefeat Mom's Heart or It Lives! on hard mode as ApollyonBurning BasementBurning BasementDefeat Mom's Heart 11 timesMarrowMarrowDefeat Mom's Heart or It Lives! on hard mode as The Forgotten


It Lives  Unlocks It Lives Unlocks It Lives  Unlocks
Added in  Afterbirth Added in Afterbirth †
Lost BabyLost BabyDefeat Mom's Heart on hard mode as IsaacCute BabyCute BabyDefeat Mom's Heart on hard mode as MagdaleneCrow BabyCrow BabyDefeat Mom's Heart on hard mode as EveShadow BabyShadow BabyDefeat Mom's Heart on hard mode as JudasGlass BabyGlass BabyDefeat Mom's Heart on hard mode as CainWrapped BabyWrapped BabyRemoved in Afterbirth † Defeat Mom's Heart on hard mode as Azazel
Added in Afterbirth † Defeat Mom's Heart on hard mode as Lazarus
Begotten BabyBegotten BabyRemoved in Afterbirth † Defeat Mom's Heart on hard mode as Lazarus
Added in Afterbirth † Defeat Mom's Heart on hard mode as Azazel
Dead BabyDead BabyDefeat Mom's Heart on hard mode as ???-0- Baby-0- BabyDefeat Mom's Heart on hard mode as The LostGlitch BabyGlitch BabyDefeat Mom's Heart on hard mode as EdenFighting BabyFighting BabyDefeat Mom's Heart on hard mode as Samson
Goat Head BabyGoat Head BabyDefeat Mom's Heart on hard mode as LilithSuper Greed BabySuper Greed BabyDefeat Mom's Heart on hard mode as Keeper SmelterSmelterDefeat Mom's Heart or It Lives! on hard mode as ApollyonFlooded CavesFlooded CavesDefeat It Lives 16 timesDank DepthsDank DepthsDefeat It Lives 21 timesScarred WombScarred WombDefeat It Lives 30 timesMarrowMarrowDefeat Mom's Heart or It Lives! on hard mode as The Forgotten


Satan  Unlocks Satan Unlocks Satan  Unlocks
Added in  Afterbirth Added in Afterbirth †
JudasJudasDefeat Satan for the 1st timeMom's KnifeMom's KnifeDefeat Satan as IsaacThe RazorThe RazorDefeat Satan as EveGuardian AngelGuardian AngelDefeat Satan as MagdaleneA Bag of BombsA Bag of BombsDefeat Satan as CainForget Me NowForget Me NowDefeat Satan as ???Blood RightsBlood RightsDefeat Satan as SamsonJudas' TongueJudas' TongueDefeat Satan as JudasThe NegativeThe NegativeDefeat Satan 5 timesBroken AnkhBroken AnkhDefeat Satan as LazarusBook of SecretsBook of SecretsDefeat Satan as EdenDaemon's TailDaemon's TailDefeat Satan as AzazelThe MindThe MindDefeat Satan as The Lost Serpent's KissSerpent's KissDefeat Satan as LilithKeeper holds Store KeyKeeper holds Store KeyDefeat Satan as KeeperI RULE!I RULE!Defeat ??? or The Lamb for the 1st time, and defeat Satan as Isaac Locust of PestilenceLocust of PestilenceDefeat Satan as ApollyonPointy RibPointy RibDefeat Satan as The Forgotten


Isaac (Boss)  Unlocks Isaac (Boss) Unlocks Isaac (Boss)  Unlocks
Added in  Afterbirth Added in Afterbirth †
A CrossA CrossDefeat Isaac as MagdaleneA Bag of PenniesA Bag of PenniesDefeat Isaac as CainThe D6The D6Defeat Isaac as ???Bloody LustBloody LustDefeat Isaac as SamsonThe PolaroidThe PolaroidDefeat Isaac 5 timesSomething IckySomething IckyDefeat Isaac 10 timesEve's Bird FootEve's Bird FootDefeat Isaac as EveIsaac's TearsIsaac's TearsDefeat Isaac as IsaacGuillotineGuillotineDefeat Isaac as JudasLazarus' RagsLazarus' RagsDefeat Isaac as LazarusBlank CardBlank CardDefeat Isaac as EdenSatanic BibleSatanic BibleDefeat Isaac as AzazelIsaac's HeartIsaac's HeartDefeat Isaac as The Lost Rune BagRune BagDefeat Isaac as LilithKeeper holds Wooden NickelKeeper holds Wooden NickelDefeat Isaac as KeeperPAY TO PLAYPAY TO PLAYDefeat Isaac as CainBRAINS!BRAINS!Defeat Isaac 5 times PONGPONGDefeat Isaac 5 timesLocust of WrathLocust of WrathDefeat Isaac as ApollyonSlipped RibSlipped RibDefeat Isaac as The Forgotten


The Lamb  Unlocks The Lamb Unlocks The Lamb  Unlocks
Added in  Afterbirth Added in Afterbirth †
Golden God!Golden God!Defeat ??? and The Lamb for the 1st timeDemon BabyDemon BabyDefeat The Lamb as AzazelAbelAbelDefeat The Lamb as CainCurved HornCurved HornDefeat The Lamb as JudasMaggy's FaithMaggy's FaithDefeat The Lamb as Magdalene???'s Soul???'s SoulDefeat The Lamb as ???Samson's LockSamson's LockDefeat The Lamb as SamsonBlack LipstickBlack LipstickDefeat The Lamb as EvePandora's BoxPandora's BoxDefeat The Lamb as LazarusMystery SackMystery SackDefeat The Lamb as EdenThe SoulThe SoulDefeat The Lamb as The LostMissing PosterMissing PosterDefeat The Lamb as Isaac SuccubusSuccubusDefeat The Lamb as LilithKarmaKarmaDefeat The Lamb as KeeperI RULE!I RULE!Defeat ??? or The Lamb for the 1st time, and defeat Satan as Isaac BackasswardsBackasswardsDefeat ??? or The Lamb for the 1st timeUltra HardUltra HardDefeat ??? or The Lamb for the first timeLocust of DeathLocust of DeathDefeat The Lamb as ApollyonOnce More with Feeling!Once More with Feeling!Complete a Victory Lap, defeating The LambZIP!ZIP!Defeat The Lamb in under 20 minutesIt's the KeyIt's the KeyDefeat The Lamb without taking hearts, coins, and bombs through an entire runThe gate is open!The gate is open!Defeat The Lamb for the 1st timeBrittle BonesBrittle BonesDefeat The Lamb as The Forgotten


??? (Boss)  Unlocks ??? (Boss) Unlocks ??? (Boss)  Unlocks
Added in  Afterbirth Added in Afterbirth †
Golden God!Golden God!Defeat ??? and The Lamb for the 1st timeThe D20The D20Defeat ??? as IsaacCeltic CrossCeltic CrossDefeat ??? as MagdaleneSacrificial DaggerSacrificial DaggerDefeat ??? as EveBlood PennyBlood PennyDefeat ??? as SamsonCain's EyeCain's EyeDefeat ??? as CainThe Left HandThe Left HandDefeat Ultra Pride or ??? as JudasFateFateDefeat ??? as ???Store CreditStore CreditDefeat ??? as LazarusMysterious PaperMysterious PaperBeat ??? as EdenAbaddonAbaddonDefeat ??? as AzazelThe BodyThe BodyDefeat ??? as The Lost Cambion ConceptionCambion ConceptionDefeat ??? as LilithDeep PocketsDeep PocketsDefeat ??? as KeeperI RULE!I RULE!Defeat ??? or The Lamb for the 1st time, and defeat Satan as Isaac BackasswardsBackasswardsDefeat ??? or The Lamb for the 1st timeUltra HardUltra HardDefeat ??? or The Lamb for the first timeLocust of FamineLocust of FamineDefeat ??? as ApollyonSomething wicked this way comes!Something wicked this way comes!Defeat ??? as 3 different charactersSomething wicked this way comes+!Something wicked this way comes+!Defeat ??? as 6 different charactersJaw BoneJaw BoneDefeat ??? as The Forgotten


Hush  Unlocks Hush Unlocks Hush  Unlocks
Added in  Afterbirth Added in Afterbirth †
Fart BabyFart BabyDefeat Hush as IsaacPurityPurityDefeat Hush as MagdaleneD12D12Defeat Hush as CainBetrayalBetrayalDefeat Hush as JudasFate's RewardFate's RewardDefeat Hush as ???AthameAthameDefeat Hush as EveBlind RageBlind RageDefeat Hush as SamsonMaw of the VoidMaw of the VoidDefeat Hush as AzazelEmpty VesselEmpty VesselDefeat Hush as LazarusEden's BlessingEden's BlessingDefeat Hush as EdenSworn ProtectorSworn ProtectorDefeat Hush as The LostIncubusIncubusDefeat Hush as LilithKeeper now holds... A Penny!Keeper now holds... A Penny!Defeat Hush as Keeper HushyHushyDefeat Hush as ApollyonNew AreaNew AreaDefeat Hush for the 1st timeHallowed GroundHallowed GroundDefeat Hush as The Forgotten


Mega Satan  Unlocks Mega Satan Unlocks Mega Satan  Unlocks
Added in  Afterbirth Added in Afterbirth †
Cry BabyCry BabyDefeat Mega Satan as IsaacRed BabyRed BabyDefeat Mega Satan as MagdaleneGreen BabyGreen BabyDefeat Mega Satan as CainBrown BabyBrown BabyDefeat Mega Satan as JudasBlue BabyBlue BabyDefeat Mega Satan as ???Lil' BabyLil' BabyDefeat Mega Satan as EveRage BabyRage BabyDefeat Mega Satan as SamsonBlack BabyBlack BabyDefeat Mega Satan as AzazelLong BabyLong BabyDefeat Mega Satan as LazarusYellow BabyYellow BabyDefeat Mega Satan as EdenWhite BabyWhite BabyDefeat Mega Satan as The LostBig BabyBig BabyDefeat Mega Satan as LilithNoose BabyNoose BabyDefeat Mega Satan as KeeperMegaMegaDefeat Mega Satan as every character Mort BabyMort BabyDefeat Mega Satan as ApollyonApollyonApollyonDefeat Mega Satan for the 1st timeBound BabyBound BabyDefeat Mega Satan as The Forgotten


Delirium  Unlocks Delirium Unlocks Delirium  Unlocks
Added in Afterbirth †
D InfinityD InfinityDefeat Delirium as IsaacEucharistEucharistDefeat Delirium as MagdaleneSilver DollarSilver DollarDefeat Delirium as CainShadeShadeDefeat Delirium as JudasKing BabyKing BabyDefeat Delirium as ???Bloody CrownBloody CrownDefeat Delirium as SamsonDull RazorDull RazorDefeat Delirium as EveEden's SoulEden's SoulDefeat Delirium as EdenDark Prince's CrownDark Prince's CrownDefeat Delirium as AzazelCompound FractureCompound FractureDefeat Delirium as LazarusEuthanasiaEuthanasiaDefeat Delirium as LilithHoly CardHoly CardDefeat Delirium as The LostCrooked PennyCrooked PennyDefeat Delirium as KeeperVoidVoidDefeat Delirium as ApollyonDeliriousDeliriousDefeat Delirium for the first time as any characterLil DeliriumLil DeliriumDefeat Delirium for the 1st timeBook of the DeadBook of the DeadDefeat Delirium as The Forgotten


Ultra Greed  Unlocks Ultra Greed Unlocks Ultra Greed  Unlocks
Added in  Afterbirth Added in Afterbirth †
Lil' ChestLil' ChestDefeat Ultra Greed as IsaacCenserCenserDefeat Ultra Greed as MagdaleneEvil EyeEvil EyeDefeat Ultra Greed as CainMy ShadowMy ShadowDefeat Ultra Greed as JudasCracked DiceCracked DiceDefeat Ultra Greed as ???Black FeatherBlack FeatherDefeat Ultra Greed as EveLusty BloodLusty BloodDefeat Ultra Greed as SamsonLilithLilithDefeat Ultra Greed as AzazelKey BumKey BumDefeat Ultra Greed as LazarusGB BugGB BugDefeat Ultra Greed as EdenZodiacZodiacDefeat Ultra Greed as The LostBox of FriendsBox of FriendsDefeat Ultra Greed as LilithRib of GreedRib of GreedDefeat Ultra Greed as Keeper Brown NuggetBrown NuggetDefeat Ultra Greed as ApollyonFinger BoneFinger BoneDefeat Ultra Greed as The Forgotten


Ultra Greedier  Unlocks Ultra Greedier Unlocks Ultra Greedier  Unlocks
Added in Afterbirth †
D1D1Defeat Ultra Greedier as IsaacGlyph of BalanceGlyph of BalanceDefeat Ultra Greedier as MagdaleneSack of SacksSack of SacksDefeat Ultra Greedier as CainEye of BelialEye of BelialDefeat Ultra Greedier as JudasMeconiumMeconiumDefeat Ultra Greedier as ???Stem CellStem CellDefeat Ultra Greedier as SamsonCrow HeartCrow HeartDefeat Ultra Greedier as EveMetronomeMetronomeDefeat Ultra Greedier as EdenBat WingBat WingDefeat Ultra Greedier as AzazelPlan CPlan CDefeat Ultra Greedier as LazarusDualityDualityDefeat Ultra Greedier as LilithDad's Lost CoinDad's Lost CoinDefeat Ultra Greedier as The LostEye of GreedEye of GreedDefeat Ultra Greedier as KeeperBlack RuneBlack RuneDefeat Ultra Greedier as ApollyonDad's RingDad's RingDefeat Ultra Greedier as The Forgotten