The Binding of Isaac: Afterbirth

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Issues: Incomplete list of additions and changes.

The Binding of Isaac: Afterbirth is the expansion to The Binding of Isaac: Rebirth. The DLC was released on October 30, 2015 and costs $10.99/£7.99. It was released on May 10, 2016 on Xbox One and PS4.

For a list of the pre-release blog posts, see The Binding of Isaac: Afterbirth (Pre-Release).

Features[edit | edit source]

Additions[edit | edit source]

Player[edit | edit source]

Characters[edit | edit source]

Character Lilith App.png
Lilith
Keeper App.png
Keeper
Health Stat Icon.png Health Full red heartFull black heartFull black heart Full coin heartFull coin heart
Damage Stat Icon.png Damage 3.5 (*1.00) 3.5 (*1.20)
Tears Stat Icon.png Tears Blindfolded.png Blindfolded
(+0)
+18
Shot Speed Stat Icon.png Shot Speed Blindfolded.png Blindfolded
(1)
1
Range Stat Icon.png Range Blindfolded.png Blindfolded
(23.75)
23.75
Speed Stat Icon.png Speed 1.0 0.85
Luck Stat Icon.png Luck 0 -2
Starting Item Icon.png Starting Pickup(s) None x1 bombs
Needs to be unlocked x1 coins
Needs to be unlocked Store Key Store Key
Starting Item Icon.png Starting Item(s) Incubus Incubus
Needs to be unlocked Cambion Conception Cambion Conception
Box of Friends Box of Friends
Triple shot
Needs to be unlocked Wooden Nickel Wooden Nickel

Transformations[edit | edit source]

Name Appearance Description Items
Bob Bob

Isaac gains a green trail of poisonous creep.

Conjoined Conjoined

When attacking, the tumor faces shoot tears diagonally outwards, similar to the effect of Added in AfterbirthThe Wiz The Wiz. Also gives -0.3 damage and slightly decreases tears.

Fun Guy Fun Guy

+1 Red Heart container.

Leviathan Leviathan

Grants flight and gives +2 black hearts.

Oh Crap Oh Crap

Whenever a pile of poop is destroyed, health is replenished by half a heart.

Seraphim Seraphim

Grants flight and gives +3 soul hearts.

Spun Spun

Gives +2 damage and +0.15 speed, and spawns a random pill upon transformation.

Super Bum Super Bum

Replaces Bum Friend Bum Friend, Dark Bum Dark Bum, and Added in AfterbirthKey Bum Key Bum for Super Bum. This bum collects any of the other beggars' pickups, and offers twice the rewards.

Yes Mother? Yes Mother?

Isaac gains a stationary knife that trails directly behind him. It synergizes like Mom's Knife Mom's Knife would.

1: Image depicts the familiar. This transformation does not alter Isaac's appearance.

Co-op[edit | edit source]

Special Babies

These Babies have special bonuses that will aid the player in some way.

ID Appearance Name Description
27 027 baby black.png Black Baby Spawns with an extra black heart.
Black Baby Defeat Mega Satan as Azazel to unlock it.
28 028 baby red.png Red Baby Spawns with an extra red heart.
Red Baby Defeat Mega Satan as Magdalene to unlock it.
29 029 baby white.png White Baby Gives Isaac an eternal heart when it spawns.
White Baby Defeat Mega Satan as The Lost to unlock it.
30 030 baby blue.png Blue Baby Spawns with an extra soul heart.
Blue Baby Defeat Mega Satan as ??? to unlock it.
31 031 baby rage.png Rage Baby Occasionally briefly increases Isaac's damage.
Rage Baby Defeat Mega Satan as Samson to unlock it.
32 032 baby cry.png Cry Baby Occasionally briefly increases Isaac's tears.
Cry Baby Defeat Mega Satan as Isaac to unlock it.
33 033 baby yellow.png Yellow Baby Occasionally briefly increases Isaac's speed by 0.15.
Yellow Baby Defeat Mega Satan as Eden to unlock it.
34 034 baby long.png Long Baby Occasionally briefly increases Isaac's range, shot speed, and tear height.
Long Baby Defeat Mega Satan as Lazarus to unlock it.
35 035 baby green.png Green Baby Occasionally briefly increases Isaac's luck by 2.
Green Baby Defeat Mega Satan as Cain to unlock it.
36 036 baby lil.png Lil' Baby Occasionally briefly decreases Isaac's size.
Lil' Baby Defeat Mega Satan as Eve to unlock it.
37 037 baby big.png Big Baby Occasionally briefly increases Isaac's size.
Big Baby Defeat Mega Satan as Lilith to unlock it.
38 038 baby brown.png Brown Baby Occasionally briefly gives Isaac the Butt Penny Butt Penny effect. While it is active, picking up a coin will make Isaac fart, knocking back nearby enemies.
Brown Baby Defeat Mega Satan as Judas to unlock it.
39 039 baby noose.png Noose Baby Occasionally briefly gives Isaac the Transcendence Transcendence effect, granting flight.
Noose Baby Defeat Mega Satan as Keeper to unlock it.
40 040 baby hive.png Hive Baby Occasionally briefly gives Isaac the Hive Mind Hive Mind effect, doubling the damage dealt by blue spiders and blue flies.
Hive Baby Earn all Hard mode completion marks as ??? to unlock it.
41 041 baby buddy.png Buddy Baby Occasionally briefly gives Isaac the Guillotine Guillotine effect, detaching Isaac's head and increasing damage and tears.
Buddy Baby Earn all Hard mode completion marks as Isaac to unlock it.
42 042 baby colorful.png Colorful Baby Upon joining, fully heals Isaac, similar to the rainbow poop effect.
Colorful Baby Earn all Hard mode completion marks as Magdalene to unlock it.
43 043 baby whore.png Whore Baby Occasionally briefly gives Isaac the Whore of Babylon Whore of Babylon effect, increasing damage and speed.
Whore Baby Earn all Hard mode completion marks as Eve to unlock it.
44 044 baby cracked.png Cracked Baby
Cracked Baby Earn all Hard mode completion marks as Eden to unlock it.
45 045 baby dripping.png Dripping Baby Occasionally briefly gives Isaac Anemic Anemic, increasing range by 5 and causing Isaac to leave a trail of blood that damages enemies.
Dripping Baby Earn all Hard mode completion marks as Lazarus to unlock it.
46 046 baby blinding.png Blinding Baby Upon death, activates the effect of XIX - The Sun, fully restoring Isaac's red hearts, deals 100 damage to all enemies in the room, and revealing the map for the current floor.
Blinding Baby Use Blank Card Blank Card while holding XIX - The Sun XIX - The Sun to unlock it.
47 047 baby sucky.png Sucky Baby Has an aura around itself that damages enemies while they are inside, similar to Succubus Succubus.
Sucky Baby Earn all Hard mode completion marks as Azazel to unlock it.
48 048 baby dark.png Dark Baby Occasionally provides a brief boost to all of Isaac's stats.
Dark Baby Earn all Hard mode completion marks as Lilith to unlock it.
49 049 baby picky.png Picky Baby
Picky Baby Earn all Hard mode completion marks as Cain to unlock it.
50 050 baby revenge.png Revenge Baby Occasionally briefly increases Isaac's damage.
Revenge Baby Earn all Hard mode completion marks as Samson to unlock it.
51 051 baby belial.png Belial Baby Occasionally briefly gives Isaac the The Book of Belial The Book of Belial effect, increasing damage.
Belial Baby Earn all Hard mode completion marks as Judas to unlock it.
52 052 baby sale.png Sale Baby Occasionally briefly gives Isaac the Steam Sale Steam Sale effect, halving the prices of all shop items.
Sale Baby Earn all Hard mode completion marks as Keeper to unlock it.
53 053 baby goatbaby.png Goat Head Baby Occasionally briefly gives Isaac the Goat Head Goat Head effect, guaranteeing that a Devil room or angel room will open if a boss room is completed while the effect is active.
Goat Head Baby Defeat Mom's Heart on Hard mode as Lilith to unlock it.
54 054 baby supergreedbaby.png Super Greed Baby Has the Head of the Keeper effect, firing coin tears that have a chance to spawn a coin upon hitting an enemy.
Super Greed Baby Defeat Mom's Heart on Hard mode as Keeper to unlock it.

Normal Babies

These Babies are purely cosmetic and do not have any special behaviors.

ID Appearance Name Description
233 233 baby punkboy.png Punkboy Baby A baby dressed as a punk rocker boy.
234 234 baby punkgirl.png Punkgirl Baby A baby dressed as a punk rocker girl.
235 235 baby computer.png Computer Baby A baby with a computer for a head.
236 236 baby mask.png Mask Baby A baby wearing a mask.
237 237 baby gem.png Gem Baby A baby that looks like it's made of crystal.
238 238 baby shark.png Shark Baby A baby that looks like a shark.
239 239 baby beret.png Beret Baby A baby that's wearing a beret.
240 240 baby blisters.png Blisters Baby A baby covered in blisters.
241 241 baby radioactive.png Radioactive Baby A sickly green baby.
242 242 baby beast.png Beast Baby A baby that looks like a beast.
243 243 baby dark.png Dark Baby A very dark baby.
244 244 baby snail.png Snail Baby A baby that looks like a snail.
245 245 baby blood.png Blood Baby A baby that looks like a drop of blood.
246 246 baby 8ball.png 8 Ball Baby A baby with an 8 ball for a head.
247 247 baby wisp.png Wisp Baby A wispy baby.
248 248 baby cactus.png Cactus Baby A baby that looks like a cactus.
249 249 baby loveeye.png Love Eye Baby A pink baby with a heart for an eye.
250 250 baby medusa.png Medusa Baby A baby that resembles Medusa.
251 251 baby nuclear.png Nuclear Baby A baby that looks like a mushroom cloud.
252 252 baby purple.png Purple Baby A strange purple baby.
253 253 baby wizard.png Wizard Baby A baby with a wizard hat.
254 254 baby earth.png Earth Baby A baby whose head looks like planet Earth.
255 255 baby saturn.png Saturn Baby A baby with a ring around its head.
256 256 baby cloud.png Cloud Baby A baby made of cloud.
257 257 baby tube.png Tube Baby A baby with a tube connecting both eyes.
258 258 baby rocker.png Rocker Baby A baby dressed as a rock fan.
259 259 baby king.png King Baby A baby with a crown.
260 260 baby coat.png Coat Baby A baby wearing a winter coat.
261 261 baby viking.png Viking Baby A baby with a Viking helmet.
262 262 baby panda.png Panda Baby A baby that looks like a panda.
263 263 baby raccoon.png Raccoon Baby A baby that looks like a raccoon.
264 264 baby bear.png Bear Baby A baby that looks like a grizzly bear.
265 265 baby polarbear.png Polar Bear Baby A baby that looks like a polar bear.
266 266 baby lovebear.png Lovebear Baby A baby that looks like a Care Bear.
267 267 baby hare.png Hare Baby A baby that looks like a rabbit.
268 268 baby squirrel.png Squirrel Baby A baby that looks like a squirrel.
269 269 baby tabby.png Tabby Baby A baby that looks like a cat.
270 270 baby porcupine.png Porcupine Baby A baby that looks like a porcupine.
271 271 baby puppy.png Puppy Baby A baby that looks like a puppy.
272 272 baby parrot.png Parrot Baby A baby that looks like a parrot.
273 273 baby chameleon.png Chameleon Baby A baby that looks like a Chameleon.
274 274 baby boulder.png Boulder Baby A baby made of rocks.
275 275 baby aqua.png Aqua Baby An aqua-blue baby.
276 276 baby gargoyle.png Gargoyle Baby A baby that resembles a gargoyle.
277 277 baby spikydemon.png Spiky Demon Baby A baby that looks like a spiky demon.
278 278 baby reddemon.png Red Demon Baby A baby that looks like a red demon.
279 279 baby orangedemon.png Orange Demon Baby A baby that looks like an orange demon.
280 280 baby eyedemon.png Eye Demon Baby A baby with an eye for a head.
281 281 baby fangdemon.png Fang Demon Baby A baby with big fangs.
282 282 baby ghost.png Ghost Baby A baby that looks like a ghost.
283 283 baby arachnid.png Arachnid Baby A baby that looks like a spider.
284 284 baby bony.png Bony Baby A baby that looks like a Bony.
285 285 baby bigtongue.png Big Tongue Baby A baby with a big tongue.
286 286 baby 3d.png 3D Baby A baby wearing 3D glasses.
287 287 baby suit.png Suit Baby A baby in a nice suit.
288 288 baby butt.png Butt Baby A baby with a butt for a face.
289 289 baby cupid.png Cupid Baby A baby that looks like Cupid.
290 290 baby heart.png Heart Baby A baby with a heart-shaped head.
291 291 baby killer.png Killer Baby A baby that looks like Jason Voorhees from the "Friday the 13th" horror movie series.
292 292 baby lantern.png Lantern Baby A baby that looks like Ash Williams from the Evil Dead series.
293 293 baby banshee.png Banshee Baby A baby that looks like a banshee.
294 294 baby ranger.png Ranger Baby A baby that looks like a Red Power Ranger.
295 295 baby rider.png Rider Baby A baby that looks like a Kamen Rider.
296 296 baby choco.png Choco Baby A baby made of chocolate.
297 297 baby woodsman.png Woodsman Baby A baby dressed as a hiker.
298 298 baby brunette.png Brunette Baby A baby with brown hair
299 299 baby blonde.png Blonde Baby A baby with blonde hair.
300 300 baby bluehair.png Blue Hair Baby A baby with blue hair
301 301 baby bloodied.png Bloodied Baby A baby covered in blood.
302 302 baby cheese.png Cheese Baby A baby made of cheese.
303 303 baby pizza.png Pizza Baby A baby made of pizza.
304 304 baby hotdog.png Hotdog Baby A baby that is also a hotdog.
305 305 baby hotdog.png Nature Baby A naked baby with a leaf.
306 306 baby borg.png Borg Baby A robotic baby.
307 307 baby corrupted.png Corrupted Baby A baby with seems to be covered by an alien life.
308 308 baby xmouth.png X Mouth Baby A gagged baby.
309 309 baby xeyes.png X Eyed Baby A comically dead baby.
310 310 baby stareyes.png Starry Eyed Baby A baby with starry eyes.
311 311 baby surgeon.png Surgeon Baby A baby ready for surgery.
312 312 baby sword.png Sword Baby A baby that's a sword.
313 313 baby monk.png Monk Baby A baby that's a monk.
314 314 baby disco.png Disco Baby A funky baby with an afro
315 315 baby puzzle.png Puzzle Baby A baby with a "Rubik's Cube" for a head
316 316 baby speaker.png Speaker Baby A baby that has a speaker for a head.
317 317 baby scary.png Scary Baby A baby that resembles Jeff the Killer.
318 318 baby fireball.png Fireball Baby A fireball with eyes. Possibly a reference to the fire enemy in the Donkey Kong and Mario games.
319 319 baby maw.png Maw Baby A baby that's just a mouth.
320 320 baby exploding.png Exploding Baby A baby that's a bomb.
321 321 baby cupcake.png Cupcake Baby A baby that's also a cupcake.
322 322 baby skinless.png Skinless Baby A baby without skin.
323 323 baby ballerina.png Ballerina Baby A baby wearing a tutu.
324 324 baby goblin.png Goblin Baby A baby that resembles a goblin.
325 325 baby coolgoblin.png Cool Goblin Baby A green baby with brown hair and cool shades.
326 326 baby geek.png Geek Baby A baby with black hair and nerdy glasses.
327 327 baby longbeard.png Long Beard Baby A baby with a long beard.
328 328 baby muttonchops.png Muttonchops Baby A baby with muttonchops.
329 329 baby spartan.png Spartan Baby A baby that resembles King Leonidas from 300.
330 330 baby tortoise.png Tortoise Baby A baby that looks like a tortoise.
331 331 baby slicer.png Slicer Baby A baby that resembles Shredder.
332 332 baby butterfly.png Butterfly Baby A baby with butterfly wings.
333 333 baby homeless.png Homeless Baby A baby that resembles a homeless person.
334 334 baby lumberjack.png Lumberjack Baby A baby that resembles a lumberjack.
335 335 baby cyberspace.png Cyberspace Baby A baby that resembles something from the Tron universe.
336 336 baby hero.png Hero Baby A baby that resembles Red from Gunstar Heroes.
337 337 baby boxers.png Boxers Baby A baby that resembles Arthur from Ghosts & Goblins (in his boxers).
338 338 baby winghelmet.png Wing Helmet Baby A baby that resembles Opa-Opa.
339 339 baby x.png X Baby A baby with an X for a head.
340 340 baby o.png O Baby A baby with an O for a head.
341 341 baby vomit.png Vomit Baby A baby with vomit coming from its mouth.
342 342 baby merman.png Merman Baby A baby that resembles Aquaman.
343 343 baby cyborg.png Cyborg Baby Might be a reference to a Cyborg from a novel/movie/game?
344 344 baby barbarian.png Barbarian Baby A baby that resembles the Barbarian from Diablo.
345 345 baby locust.png Locust Baby A baby that resembles a locust.
346 346 baby twotone.png Twotone Baby A completely white baby with a black outline.
347 347 baby 2600.png 2600 Baby A baby that resembles an Atari 2600 sprite.
348 348 baby fourtone.png Fourtone Baby A baby with a minimal colour sprite.
349 349 baby grayscale.png Grayscale Baby A baby colored with several shades of gray.
350 350 baby rabbit.png Rabbit Baby A baby that resembles Oswald the Lucky Rabbit.
351 351 baby mouse.png Mouse Baby A baby that resembles an old-style Mickey Mouse.
352 352 baby critter.png Critter Baby A critter that looks white and hairy. Might be a reference to the movie Critters.
353 353 baby bluerobot.png Blue Robot Baby A baby that resembles Mega Man.
354 354 baby pilot.png Pilot Baby A baby that resembles Jason from Blaster Master.
355 355 baby redplumber.png Red Plumber Baby A baby that resembles Mario.
356 356 baby greenplumber.png Green Plumber Baby A baby that resembles Luigi.
357 357 baby yellowplumber.png Yellow Plumber Baby A baby that resembles Wario.
358 358 baby purpleplumber.png Purple Plumber Baby A baby that resembles Waluigi.
359 359 baby tanooki.png Tanooki Baby A baby that's wearing a Tanooki Suit.
360 360 baby mushroomman.png Mushroom Man Baby A baby that resembles Toad.
361 361 baby mushroomgirl.png Mushroom Girl Baby A baby that resembles Toadette.
362 362 baby cannonball.png Cannonball Baby A baby that resembles a Chain Chomp.
363 363 baby froggy.png Froggy Baby A baby that's wearing a Frog Suit.
364 364 baby turtledragon.png Turtle Dragon Baby A baby that resembles Bowser.
365 365 baby shellsuit.png Shell Suit Baby A baby wearing a Hammer Suit.
366 366 baby fiery.png Fiery Baby A baby wearing a Fire Suit.
367 367 baby meanmushroom.png Mean Mushroom Baby A baby that resembles a Goomba.
368 368 baby arcade.png Arcade Baby A baby that resembles Pac-Man.
369 369 baby scaredghost.png Scared Ghost Baby A blue ghost with a scared expression.
370 370 baby blueghost.png Blue Ghost Baby A baby that resembles Inky.
371 371 baby redghost.png Red Ghost Baby A baby that resembles Blinky.
372 372 baby pinkghost.png Pink Ghost Baby A baby that resembles Pinky.
373 373 baby orangeghost.png Orange Ghost Baby A baby that resembles Clyde.
374 374 baby pinkprincess.png Pink Princess Baby A baby that resembles Princess Peach.
375 375 baby yellowprincess.png Yellow Princess Baby A baby that resembles Princess Daisy.
376 376 baby dino.png Dino Baby A baby that resembles Yoshi.
377 377 baby elf.png Elf Baby A baby that resembles Link.
378 378 baby darkelf.png Dark Elf Baby A baby that resembles Dark Link
379 379 baby darkknight.png Dark Knight Baby A baby that resembles a Darknut
380 380 baby octopus.png Octopus Baby A baby that resembles an Octorok.
381 381 baby orangepig.png Orange Pig Baby A baby that resembles an orange Moblin.
382 382 baby bluepig.png Blue Pig Baby A baby that resembles a blue Moblin.
383 383 baby elfprincess.png Elf Princess Baby A baby that resembles Princess Zelda.
384 384 baby fishman.png Fishman Baby A baby that resembles a Zora.
385 385 baby fairyman.png Fairyman Baby A baby that resembles Tingle.
386 386 baby imp.png Imp Baby A baby that resembles Midna.
387 387 baby worm.png Worm Baby A baby that resembles Earthworm Jim.
388 388 baby bluewrestler.png Blue Wrestler Baby A baby that looks like the blue player in Smash TV.
389 389 baby redwrestler.png Red Wrestler Baby A baby that looks like the red player in Smash TV.
390 390 baby toast.png Toast Baby A baby that resembles Powdered Toast Man.
391 391 baby roboboy.png Roboboy Baby A baby that resembles Astro Boy.
392 392 baby liberty.png Liberty Baby A baby that resembles the Statue of Liberty.
393 393 baby dreamknight.png Dream Knight Baby A baby that resembles Meta Knight.
394 394 baby cowboy.png Cowboy Baby A baby that's wearing a cowboy outfit.
395 395 baby mermaid.png Mermaid Baby A baby that resembles Ariel.
396 396 baby plague.png Plague Baby A baby wearing a plague doctor outfit.
397 397 baby spacesoldier.png Space Soldier Baby A baby that resembles a Warhammer 40k Space Marine.
398 398 baby darkspacesoldier.png Dark Space Soldier Baby A baby that resembles a Warhammer 40k Chaos Space Marine.
399 399 baby gasmask.png Gas Mask Baby A baby that's wearing a gas mask.
400 400 baby tomboy.png Tomboy Baby A baby that resembles Sheik from the Legend of Zelda franchise.
401 401 baby corgi.png Corgi Baby A baby that looks like a corgi.
402 402 baby unicorn.png Unicorn Baby A baby that looks like a unicorn.
403 403 baby pixie.png Pixie Baby A baby that resembles Tinkerbell.
404 404 baby referee.png Referee Baby A baby wearing a referee outfit.
405 405 baby dealwithit.png Deal With It Baby A baby with a goatee and sunglasses.
406 406 baby astronaut.png Astronaut Baby A baby that's wearing an astronaut outfit.
407 407 baby blurred.png Blurred Baby A baby with a blur effect across its privates.
408 408 baby censored.png Censored Baby A baby with a censor bar across its privates.
409 409 baby coolghost.png Cool Ghost Baby A baby that resembles the character Shades (Sukezaemon) from Ufouria: The Saga.
410 410 baby gills.png Gills Baby A baby that resembles the character Gil (Jennifer) from Ufouria: The Saga.
411 411 baby bluehat.png Blue Hat Baby A baby that resembles the character Bop-Louie (Hebe) from Ufouria: The Saga.
412 412 baby catsuit.png Catsuit Baby A baby that's wearing a cat outfit. Also resembles the character Oh-Chan from Ufouria: The Saga (Japanese version).
413 413 baby pirate.png Pirate Baby A baby that's wearing a pirate outfit.
414 414 baby superrobo.png Super Robo Baby A baby that resembles Tekkaman the Space Knight.
415 415 baby lightmage.png Lightmage Baby A baby that resembles the white mage class from Final Fantasy.
416 416 baby puncher.png Puncher Baby A baby that resembles the warrior class from Final Fantasy.
417 417 baby holyknight.png Holy Knight Baby A baby that resembles the monk class from Final Fantasy.
418 418 baby shadowmage.png Shadowmage Baby A baby that resembles the black mage class from Final Fantasy.
419 419 baby firemage.png Firemage Baby A baby that resembles the red mage class from Final Fantasy.
420 420 baby priest.png Priest Baby A baby that's wearing a priest outfit.
421 421 baby zipper.png Zipper Baby A baby with a zipped mouth.
422 422 baby bag.png Bag Baby A baby with a bag over its head.
423 423 baby sailor.png Sailor Baby A baby that's wearing a sailor outfit.
424 424 baby rich.png Rich Baby A baby with a top hat and monocle.
425 425 baby toga.png Toga Baby A baby in an ancient Roman outfit.
426 426 baby knight.png Knight Baby A baby that resembles a Darknut from The Legend of Zelda.
427 427 baby blackknight.png Black Knight Baby A baby that resembles a black Darknut from The Legend of Zelda.


Items[edit | edit source]

95 new items were added in the expansion: 19 activated items and 76 passive items.

Activated Collectibles[edit | edit source]

Name ID Icon Quote Description
Box of Friends 357
Box of Friends
4 rooms
Double your friends Upon use, duplicates all of Isaac's familiars for the current room.
D12 386
D12
3 rooms
Rerolls rocks Re-rolls all rocks in the current room into other random objects, such as bomb rocks, metal blocks, TNT, or poops.
D7 437
D7
3 rooms
Reroll rewards! Restarts the current room and brings back all enemies, allowing more rewards to be acquired by completing the room.
D8 406
D8
4 rooms
Reroll stats Re-rolls Isaac's speed, range, tears, and damage.
Diplopia 347
Diplopia
One time use
Double item vision Duplicates all pickups and item pedestals in the room.
Friendly Ball 382
Friendly Ball
3 rooms
Gotta fetch 'em all! Throwing the ball at an enemy instantly kills it and captures it. The captured enemy can later be released and will be friendly, fighting for Isaac and persisting between rooms.
Glass Cannon 352
Glass Cannon
4 seconds
Be gentle... Reduces Isaac's health to half a heart (including Soul and Black Hearts) and fires one large piercing spectral tear that does a lot of damage when used. The damage done by Glass Cannon scales with Isaac's damage (at base damage it does 45 damage).
Glowing Hour Glass 422
Glowing Hour Glass
2 rooms
Turn back time When used, this item will rewind time, put Isaac back in the previous room, and undo anything that happened in the current room. Any health, pickups, or items gained or lost will be reset back to the previous state.
Jar of Flies 434
Jar of Flies
Unlimited
Gotta catch 'em all? Every time Isaac kills an enemy, a fly will be added to the jar, up to a maximum of 20. Using the Jar of Flies will release all the flies that are currently in the jar as friendly blue flies that will damage enemies.
Kidney Bean 421
Kidney Bean
2 rooms
Love toots! Upon use, Isaac farts, charming all nearby enemies.
Mega Bean 351
Mega Bean
3 rooms
Giga fart! When used, the Mega Bean will freeze all enemies in the current room for a couple of seconds, deal 5 damage and poison any enemies near Isaac, and send a wave of spikes that deals 10 damage across the room in the direction Isaac is facing.
Mega Blast 441
Mega Blast
12 rooms
Laser breath Upon use, Isaac fires a laser similar to the one used by Mega Satan. This laser deals massive damage, lasts for approximately 15 seconds, and persists between rooms. Isaac is pushed backwards by the force of the laser while it is active.
Mine Crafter 427
Mine Crafter
1 rooms
Booom! Places an explosive TNT barrel that can be pushed and used to destroy rocks or damage enemies when used. If used a second time in the same room while the previous TNT barrel is still intact, it will remotely explode the TNT.
Mom's Box 439
Mom's Box
4 rooms
What's inside? When used, Mom's Box will drop a random trinket on the ground. While held, increases luck by 1 and doubles the effects of trinkets.
Placebo 348
Placebo
4 rooms
Pill mimic When used, copies the effect of the pill Isaac is currently holding without consuming it. Does not copy the effects of cards or runes.
Tear Detonator 383
Tear Detonator
1 rooms
Remote tear detonation! When used, will detonate any tears currently on the screen and cause each one to split into 6 more tears which will fire in a circle, similar to Tammy's Head.
Teleport 2.0 419
Teleport 2.0
4 rooms
I-Teleport! Teleports Isaac to a random room that has not been explored yet when used. If all rooms are explored, including secret rooms, it will teleport Isaac to the Devil or Angel room. If all rooms are explored, including the Devil or Angel room, it will teleport Isaac to the I AM ERROR room. If used in a room with enemies, it will teleport Isaac out and back into the same room.
Ventricle Razor 396
Ventricle Razor
Unlimited
Short cutter Can be used to place an orange portal and a blue portal. Upon entering a portal, Isaac is teleported to the other portal.
Wooden Nickel 349
Wooden Nickel
1 rooms
Flip a coin When used, has a 50% chance to drop one random type of coin (Penny, Nickel, or Dime).

Passive Collectibles[edit | edit source]

Name ID Icon Quote Description
8 Inch Nails 359 8 Inch Nails Stick it to 'em! +1.5 Damage Up. Replaces Isaac's tears with nails, which have increased knockback.
Athame 408 Athame Call to the void Whenever Isaac takes damage, a black ring briefly appears around Isaac, dealing damage to all nearby enemies.
Betrayal 391 Betrayal Turn your enemy Every time Isaac takes damage, a charm effect is applied to every enemy in the room, causing them to attack each other rather than Isaac.
Binky 438 Binky Memories... Tears up, adds 1 Soul Heart, and decreases Isaac's size.
Black Powder 420 Black Powder Spin the black circle! Isaac leaves a trail of black powder on the floor. Walking in a circle will spawn a pentagram symbol on the floor, which deals 10 damage per tick to any enemies inside it.
Bomber Boy 353 Bomber Boy Explosive blast! +5 bombs. Isaac's bombs will now explode in a large cross-shaped pattern (roughly 5 bombs explosions wide). This also affects player-spawned Troll Bombs.
Bumbo 385 Bumbo Bumbo want coin! Spawns a Beggar familiar which floats around the room and picks up any nearby coins, leveling up after collecting several coins. At level 2, Bumbo gains a body. At level 3, it begins to fire tears. At level 4, Bumbo chases enemies slowly, doing contact damage.
Bursting Sack 377 Bursting Sack Spider love Spider enemies no longer target or deal contact damage to Isaac.
Cambion Conception 412 Cambion Conception Feed them hate After taking damage a certain amount of times, a permanent demonic familiar spawns.
Car Battery 356 Car Battery Double charge! Causes Isaac's activated item to activate twice on each use.
Censer 387 Censer Peace be with you Gives Isaac a golden censer familiar which creates a huge aura of light that slows down any enemies and enemy shots inside it.
Chaos 402 Chaos !!! Chaos causes items to be chosen from random item pools. When picked up, drops between 1-6 random pickups on the floor.
Charged Baby 372 Charged Baby Bbbzzzzzt! A familiar that may drop a Lil' Battery. Has a small chance to freeze all enemies in the room.
Circle of Protection 423 Circle of Protection Protect me from myself Surrounds Isaac with a large white halo. Once per second, the halo deals Isaac's tear damage to enemies inside it. It may also convert enemy shots entering the halo into friendly purple homing tears.
Continuum 369 Continuum Transcendent tears +2.25 range up. +1.5 tear height. Isaac's tears travel through walls and appear out of the opposite wall. Isaac's tears also travel over rocks and objects.
Crack Jacks 354 Crack Jacks Don't swallow the prize! Adds one Red Heart container and drops a random trinket.
Crown of Light 415 Crown of Light The untainted gain power Grants double damage diamond tears while Isaac has no damaged red health containers. Regardless of health, the crown will deactivate for the current room when Isaac takes damage.
Curse of the Tower 371 Curse of the Tower You feel cursed... Causes Isaac to spawn 6 Troll Bombs on the floor every time he gets hit, similar to the Anarchist Cookbook Anarchist Cookbook mechanic.
Dead Eye 373 Dead Eye Accuracy brings power! Isaac's damage increases each time an enemy is hit. Damage is reset upon missing a shot.
Deep Pockets 416 Deep Pockets More stuff to carry! Allows Isaac to carry two cards or pills (or a combination of both) at the same time.
Eden's Blessing 381 Eden's Blessing Your future shines brighter +0.7 tears up. Grants a random item at the start of the next run.
Empty Vessel 409 Empty Vessel I reward an empty vessel While Isaac has no red hearts, this item grants flight and a random chance to activate an invincibility shield for a few seconds. If Isaac gains any Red Hearts, these benefits will disappear.
Epiphora 368 Epiphora Intensifying tears Shooting in one direction increases Isaac's rate of fire until the cap is reached. As soon as Isaac changes direction or stops shooting, rate of fire is reset to its normal amount.
Evil Eye 410 Evil Eye Eye shot! While firing tears, Isaac has a chance to fire an eye across the screen with a very slow shot speed, which will fire tears of its own in the same direction as Isaac. The eye will be destroyed if it comes into contact with an enemy or obstacle.
Explosivo 401 Explosivo Sticky bomb shot! Isaac's tears have a chance to stick to enemies and explode.
Farting Baby 404 Farting Baby It farts! A familiar that follows Isaac and blocks tears. If a tear hits Farting Baby, there is a high chance for it to fart, which will either knockback, poison, or charm all nearby enemies.
Fate's Reward 361 Fate's Reward Your fate beside you A blue head familiar that will follow Isaac and fire tears copying his tear effects and damage.
Friend Zone 364 Friend Zone Friendly fly A white orbiting fly which deals 3 contact damage per tick to enemies. This familiar orbits Isaac at a middle length distance somewhere between Distant Admiration Distant Admiration and Forever Alone Forever Alone.
Fruit Cake 418 Fruit Cake Rainbow effects! Isaac's tears gain a random effect that changes every shot.
GB Bug 405 GB Bug Game breaking bug, right away! A glitch familiar that bounces around the room and applies a random status effect to any enemies it comes into contact with and has a chance to re-roll pickups that it passes over.
Glitter Bombs 432 Glitter Bombs Prize bombs! Gives Isaac 5 bombs, and makes Isaac's bombs have a chance to drop random pickups or charm enemies when they explode.
God's Flesh 398 God's Flesh Shrink shot Tears now have a random chance to apply a shrinking effect, causing enemies to shrink in size and also run away from Isaac. Shrunk enemies can be crushed and killed by walking over them.
Head of the Keeper 429 Head of the Keeper Penny tears! Isaac's tears become coins and now have a chance to drop Pennies on the floor upon successfully hitting an enemy.
Holy Light 374 Holy Light Holy shot! Isaac has a random chance to fire a Holy tear, which, when it hits an enemy, will spawn a Crack the Sky-style light beam on the same enemy, dealing damage.
Host Hat 375 Host Hat Nice hat! A host familiar that sits on Isaac's head and has a random chance to block enemy shots and retaliate with 3 tears. Grants immunity to explosions.
Immaculate Conception 413 Immaculate Conception Feed them love Upon picking up a certain amount of health, spawn a permanent angelic familiar.
Incubus 360 Incubus Dark friend A demonic familiar that follows Isaac and shoots tears identical to Isaac's in terms of damage, range, fire rate, and effects.
Key Bum 388 Key Bum He wants your keys! Spawns a portable key master that follows Isaac and collects keys, giving random chests in return.
Kidney Stone 440 Kidney Stone Matt's kidney stone Randomly while firing tears, Isaac will stop firing and turn red, where he will charge and release a lot of 'tears' in one go. In the burst of tears is a kidney stone which deals a lot of damage.
Lil Chest 362 Lil Chest What's in the box? Spawns a chest familiar that follows Isaac and drops a random pickup every few rooms.
Lil Gurdy 384 Lil Gurdy A gurd of your own! Gives Isaac a Gurdy familiar that will charge around the room dealing contact damage to enemies. Lil Gurdy is charged by holding down a fire button and letting go. The longer the button is held, the faster Lil Gurdy will fling itself across the screen. Lil Gurdy can pass over objects and obstacles in the room.
Lil' Loki 435 Lil' Loki 4-way buddy! A Loki familiar that follows Isaac and shoots 4 tears in a cross pattern.
Lost Fly 365 Lost Fly Lost protector A familiar fly that moves in a straight line and attaches itself to the first obstacle or wall it comes into contact within each room. If any enemies walk into its path, it will do 7 contact damage per tick. If the obstacle it is attached to is destroyed then it will continue rolling in the direction it was previously traveling until it meets another wall or obstacle.
Lusty Blood 411 Lusty Blood Their blood brings rage! Each time Isaac kills an enemy, Isaac's damage increases for the current room.
Marked 394 Marked Directed tears Isaac will now fire tears automatically directed at a red target on the ground which is controlled by the player. This allows for a full 360-degree tear firing radius. It can be overridden by other tear modifiers such as Mom's Knife or Brimstone.
Maw of the Void 399 Maw of the Void Consume thy enemy! +1.0 Damage Up. After continuously firing tears for 2.5 seconds, a red cross appears on Isaac's head that, upon releasing the fire button, creates a black ring that rapidly deals damage equal to Isaac's tear damage to any enemies in contact with it.
Milk! 436 Milk! Don't cry over it... A glass of milk follows Isaac and spills on the floor upon taking damage. After the milk spills, Isaac's tear delay is decreased by 2 for the rest of the room.
Mom's Pearls 355 Mom's Pearls Range + luck up +1.25 Range Up. +0.5 Tear Height. +1 Luck Up.
More Options 414 More Options There are even more options! Two items spawn in every Treasure Room. Only one can be taken; the other will disappear.
Mr. Dolly 370 Mr. Dolly Range + tears up Tears and Range up. Spawns 3 random types of hearts on the floor when picked up.
Multidimensional Baby 431 Multidimensional Baby ydduB Buddy Spawns a familiar that will follow Isaac's movements on a 2.5-second delay. Tears that pass through the baby will be doubled and increase in speed.
My Shadow 433 My Shadow Me! And my shaaaadow! Each time Isaac takes damage, inflicts fear on all enemies in the room and spawns a black friendly Charger that will attack enemies. The Charger will be killed if it is damaged too much.
Night Light 425 Night Light Scared of the dark? A cone of light shines in the direction Isaac is moving that slows enemies and enemy shots.
No. 2 378 No. 2 Uh oh... Continuously firing tears for several seconds causes Isaac to drop a Butt Bomb. Butt Bombs explode for 60 damage like normal bombs, but also deal 10 damage to all enemies in the room and daze them for a short period of time.
Obsessed Fan 426 Obsessed Fan Follows my every move... A purple fly familiar that follows Isaac's movements on a 3 second delay and deals contact damage to enemies.
Papa Fly 430 Papa Fly Turret follower A blue fly familiar follows Isaac's movements on a 3 second delay. Papa Fly will fire tears at nearby enemies.
Pay to Play 380 Pay to Play Money talks This item turns all doors that require a single key into doors which need a coin to enter instead. This affects shops, item rooms and libraries.
PJs 428 PJs You feel cozy Grants four soul hearts and fully restores Isaac's red health.
Pupula Duplex 379 Pupula Duplex Wide shot Transforms Isaac's tears into a wide arc shape which gives them a much larger hitbox. Gives Isaac spectral tears which allows them to travel through objects in the environment (i.e. rocks).
Purity 407 Purity Aura stat boost This item will boost one of Isaac's stats depending on the color of the aura around him. The aura will disappear upon taking damage and will reappear with a random color upon entering a new room. A red aura boosts damage, a blue aura boosts the rate of fire, a yellow aura boosts speed, and an orange aura boosts range.
Restock 376 Restock Never ending stores! Causes shops to instantly restock their items when they are bought. Granted by default for every character in Greed Mode.
Rune Bag 389 Rune Bag Rune generator A bag that follows Isaac and drops a random rune every 5-6 rooms.
Sack Head 424 Sack Head More sacks! Greatly increases the chance to find sacks.
Scatter Bombs 366 Scatter Bombs We put bombs in your bombs! Adds 5 bombs. Isaac's bombs explode into 2-4 tiny bombs.
Seraphim 390 Seraphim Sworn friend An angel familiar which follows Isaac and fires homing tears which deal 10 damage at -25% shot speed and a reduced fire rate.
Serpent's Kiss 393 Serpent's Kiss The kiss of death Tears now have a random chance to apply a poison effect, causing 4 or 6 damage per tick to enemies (Similar to The Common Cold item). Isaac now deals poison damage on contact with enemies similar to The Virus item (Damage over time 4 or 6 per tick). Enemies that were poisoned have a chance to drop a black heart when killed.
Spear of Destiny 400 Spear of Destiny Your destiny In addition to tears, Isaac now holds a spear in front of him which deals damage equal to 2 times his tear damage, and occasionally inflicts fear. The spear cannot be thrown but deals damage while it is in contact with an enemy.
Spider Mod 403 Spider Mod Mod buddy! Displays Isaac's tear damage and enemy health bars. Spawns a gray spider familiar that wanders around and inflicts a random status effect on any enemies it comes into contact with. Occasionally spawns a blue spider upon clearing a room.
Sticky Bombs 367 Sticky Bombs Egg sack bombs! +5 bombs. Bombs stick to enemies and spawn 2-4 Blue Spiders if they kill an enemy.
Succubus 417 Succubus Damage booster Spawns a flying familiar that bounces around the room with a black aura, dealing rapid damage to any enemies inside it. While standing in the aura, Isaac gains a 1.5x tear damage multiplier.
Sworn Protector 363 Sworn Protector Protective friend An orbital angel which does 7 contact damage per tick and blocks enemy shots. Upon blocking 10 shots in a room it drops an Eternal Heart.
Tech X 395 Tech X Laser ring tears Tears are replaced with laser rings that pierce through enemies and deal damage to enemies within them. Can be charged to increase the size of the ring.
The Wiz 358 The Wiz Double wiz shot! Tears simultaneously fire out of both eyes diagonally, similar to the effect of the R U A Wizard? pill. Isaac's tears also travel above all obstacles.
Toxic Shock 350 Toxic Shock Mass poison Upon entering a room, poisons all enemies, dealing double Isaac's tear damage. Killing enemies leaves a small, short lasting pool of green creep on the ground.
Tractor Beam 397 Tractor Beam Control your tears Isaac emits a beam from his face. Isaac's tears travel in the path of the beam.
Zodiac 392 Zodiac The heavens will change you Zodiac will give Isaac a random zodiac item effect that changes after every floor.

Trinkets[edit | edit source]

29 new trinkets were added in the expansion.

Name ID Icon Quote Description
Black Feather 80 Black Feather With darkness comes power Increases Isaac's damage for possessing certain evil items.
Blasting Cap 73 Blasting Cap Pop! Pop! Exploding bombs have a chance to drop another Bomb pickup.
Blind Rage 81 Blind Rage Blind to damage Increases invincibility time after getting hit.
Blister 77 Blister Bounce back! Increases knockback of tears.
Bob's Bladder 71 Bob's Bladder Creepy bombs Leaves a pool of green creep under all bombs Isaac places, which damages enemies that walk over it.
Brown Cap 90 Brown Cap Fartoom! Poop blocks will explode after being destroyed.
Child Leash 89 Child Leash Keep your friends close... Causes familiars to stay closer to each other.
Cracked Dice 67 Cracked Dice You feel cursed... kinda. Activates the effect of The D6 The D6, Added in AfterbirthD8 D8, Added in AfterbirthD12 D12, or D20 D20 whenever Isaac takes damage.
Endless Nameless 79 Endless Nameless I'm stuck in a loop... Has a 25% chance of creating a duplicate of any pill, card, or rune Isaac uses.
Error 75 Error Effect not found? Gives a random trinket effect each room.
Faded Polaroid 69 Faded Polaroid You feel faded Occasionally causes Isaac to blend into the ground, which briefly confuses all enemies in the room.
Golden Horse Shoe 82 Golden Horse Shoe Feel lucky? +15% chance for a Treasure Room with two items to spawn.
Karma 85 Karma Karma up Donating to a donation machine has a chance to heal Isaac for a full red heart or spawn a beggar. Increases the chance that donating to a Donation Machine will increase Isaac's luck.
Lazy Worm 66 Lazy Worm Pft Increases Range by 4 and decreases Shot Speed by .4.
Lil Larva 86 Lil Larva The poop is moving... Spawns a blue fly from every pile of poop that Isaac destroys.
Louse 70 Louse Itchy, tasty... Occasionally spawns a blue spider.
Mom's Locket 87 Mom's Locket You feel her love Grants half a red heart each time a key is used. Converts half red heart pickups into full red hearts.
NO! 88 NO! Never again! Prevents active items from being generated, if possible.
Poker Chip 76 Poker Chip It's double down time! Chests have a 50% chance of paying out with extra pickups and a 50% chance of paying out with nothing or enemies.
Rainbow Worm 64 Rainbow Worm Bleep Bloop Blop Isaac's tears gain a worm effect that changes every 3 seconds.
Rib of Greed 84 Rib of Greed Feels greedy Prevents Greed and Super Greed from appearing in shops and secret rooms, and makes coin drops after clearing rooms more likely.
Safety Scissors 63 Safety Scissors Fuse Cutter Troll bombs turn into Bomb pickups before they explode. Mega troll bombs turn into 1+1 free bombs before they explode.
Second Hand 78 Second Hand Extended stat effect time! Increases the time that status effects stay on enemies.
Shiny Rock 62 Shiny Rock It shines for its brothers Tinted rocks and rocks with crawl spaces flash white upon entering the room and every 10 seconds afterward.
Store Key 83 Store Key Stores are open Shops can be opened without using keys.
Stud Finder 74 Stud Finder The ground below feels hollow... Increases the chance to find a Crawl Space.
Super Magnet 68 Super Magnet It Pulls Pulls enemies and pickups towards Isaac.
Tape Worm 65 Tape Worm Floooooooooop! Doubles Isaac's range and halves his tear height.
Watch Battery 72 Watch Battery Lil charge Increased chance of batteries spawning. Has a chance to add an extra charge to Isaac's activated item upon completing a room.

Pickups[edit | edit source]

Hearts[edit | edit source]

Heart Image Worth Additional Info Unlocked By
Gold Heart Gold Heart.png Full red heart When a Gold Heart is lost, a few coins will be dropped around you. Gold Heart Complete XXXXXXXXL (challenge #21)

Coins[edit | edit source]

Coin Image Worth Additional Info Unlocked By
Lucky Penny Lucky Penny.png 1

Increases luck by 1 when picked up.

Lucky Pennies Donate 1 coin to the Greed Donation Machine
Sticky Nickel Nickel.png 5

Will flip upside-down when Isaac tries to collect it. Afterwards, it will get stuck on the ground, unable to be picked up unless blasted off the ground with an explosion.

Sticky Nickels Complete the Boss Rush as Keeper

Bombs[edit | edit source]

Bomb Image Worth Additional Info Unlocked By
Gold Bomb Golden Bomb.png

Will not add to the player's bomb count, but when picked up, it will give the player unlimited bombs for the duration of the current floor, even if the current number of bombs is 0.

Gold Bomb Complete Blue Bomber (challenge #23)

Pills[edit | edit source]

ID Pill Effect
28 Needs to be unlocked Percs!

Gives The Wafer The Wafer effect while in the room. Unlocked by completing Challenge #24: PAY TO PLAY.

29 Needs to be unlocked Addicted!

Makes Isaac take a full heart of damage from all sources for the current room. Unlocked by completing Challenge #24: PAY TO PLAY.

30 Needs to be unlocked Re-Lax

For a short time, poop spawns wherever Isaac moves, like Explosive Diarrhea but with poop. A higher move speed means you can touch more tiles in the same time. A pun on laxatives. Unlocked by completing Challenge #25: Have a Heart.

31 Needs to be unlocked ???

Gives the Curse of the Maze effect for the remainder of the floor. The effect can stack with other curses. If no other curses are active for the floor, Curse of the Maze will appear under the level name when TAB is held. This effect cannot be negated by Black Candle Black Candle. Unlocked by completing Challenge #25: Have a Heart.

32 One makes you larger

Increases Isaac's size and decreases the pitch of his voice. This effect does not increase the size of Isaac's hitbox. These pills contribute to the Stompy transformation.

33 One makes you small

Decreases Isaac's size and increases the pitch of his voice. This effect decreases the size of Isaac's hitbox.

34 Infested!

Destroys all poop in the room and spawns a single Blue Spider under Isaac and on each destroyed poop.

35 Infested?

Spawns Blue Spiders equal to the number of enemies in the room. If there are no enemies in the room, spawns 1-3 Blue Spiders.

36 Power Pill!

Activates an effect similar to The Gamekid The Gamekid.

37 Retro Vision

Briefly pixelates the screen 3 times over 30 seconds.

38 Friends Till The End!

Spawns three blue flies.

Cards[edit | edit source]

Name ID Icon Message Effect
? Card 48 ? Card Double active When used, copies the effect of Isaac's currently held activated collectible.
Get out of Jail Free Card 47 Get out of Jail Free Card Open Sesame Upon use, opens all doors in the current room (including the golden door at The Chest / Dark Room), similar to Dad's Key.

Runes[edit | edit source]

Rune ID Icon Unlock method Message Effect
Blank Rune 40 Blank Rune ??? Grants a random rune effect (excluding the Black Rune). Has a 25% chance to spawn another Blank Rune upon use.

Consumables[edit | edit source]

Name ID Icon Message Effect
Dice Shard 49 Dice Shard D6 + D20 Upon use, activates the effects of The D6 and the D20 at the same time.
Emergency Contact 50 Emergency Contact Help from above When used, will cause two Mom's Hands to come down and grab two random enemies.

Chests[edit | edit source]

Eternal Chest.png Eternal Chests
  • Eternal Chests are similar in appearance to Gold Chests, except they glow bright blue instead of gold, like a soul heart. They require one key to unlock, but can be reopened a random amount of times, each time requiring another key. They can be found in Angel rooms, in I AM ERROR Rooms and rarely in a normal room. Their loot is similar to Golden Chests, but there is a 25% chance they will drop nothing upon opening. If they contain nothing or an item, they will no longer be able to be reopened.
Spiked Chest.png Spiked Chests
  • Spiked Chests are purple colored chests with spikes protruding from them that will deal damage to Isaac upon opening unless he has the Holy Mantle active, which nullifies the damage, or if found in The Chest/Dark Room, where they are free to open. They can be rarely found upon completing a room or in greed mode shops. Their loot is similar to Brown Chests. Unlike other chests, they do not appear on the minimap.

Sacks[edit | edit source]

Grab Bag.png Mystery sack
  • Spawns 1-4 random pickups upon touching it. It will not drop any hearts, pills or chests, and they have an increased chance to drop batteries.

Entities[edit | edit source]

Monsters[edit | edit source]

Monster Description
Flaming Gaper
Flaming Gaper
Walks towards Isaac, dealing contact damage. Usually turns into a Pacer or a Gusher upon death.
Drowned Hive
Drowned Hive
Walks around the room, avoiding Isaac while spawning Drowned Chargers. Spawns a Drowned Charger upon death.
Drowned Charger
Drowned Charger
Slowly moves around the room, charging at Isaac when he gets in its line of sight. Explodes into four blood shots in the ordinal directions upon death.
Dank Globin
Dank Globin
Chases Isaac, dealing a full heart of contact damage. Upon taking enough damage, it collapses into a pile of goo, spawns a Spider, and leaves a puddle of slowing Black Creep. Will regenerate after a short time if not killed quickly. Leaves another puddle of Black Creep upon death.
Drowned Boom Fly
Drowned Boom Fly
Flies around the room diagonally, dealing touch damage. Upon death, explodes and fires four blood shots in the cardinal directions. High chance to spawn a Drowned Charger upon death.
Scarred Double Vis
Scarred Double Vis
Randomly wanders around the room. Pauses to charge and fire a Brimstone laser which fires from all four cardinal sides when Isaac gets in its line of sight.
Scarred Guts
Scarred Guts
Attaches itself to a wall or obstacle and rolls around it, leaving a trail of damaging Red Creep.
Scarred Para-Bite
Scarred Para-Bite
Moves towards Isaac, dealing contact damage and firing a short-range blood shot at him. Can burrow underground and reappear elsewhere.
Flaming Fatty
Flaming Fatty
Slowly walks towards Isaac. Occasionally farts, which pushes Isaac and adjacent enemies away. Has a chance to leave behind a damaging flame upon death.
Dank Death's Head
Dank Death's Head
Moves diagonally around the room, dealing contact damage. Needs to be killed to complete the room.
Corn
Corn
Quickly dashes in random directions, dealing contact damage.
Brownie Corn
Brownie Corn
Quickly dashes in random directions, dealing contact damage.
Dank Squirt
Dank Squirt
Dashes towards the player and deals contact damage. Spawns 2 Clots upon death.
Rag man's Rag Ling
Rag man's Rag Ling
Quickly leaps towards Isaac and deals touch damage. Randomly shoots two purple shots that orbit around it.
Dart Fly
Dart Fly
Flies towards Isaac and attempts to mimic his movements. Deals contact damage.
Conjoined Fatty
Conjoined Fatty
Slowly walks towards Isaac. Occasionally pauses to fart out a line of damaging Green Creep towards Isaac. Chance to turn into a regular Fatty upon death.
Blue Conjoined Fatty
Blue Conjoined Fatty
Slowly walks towards Isaac and occasionally farts out a homing Ipecac shot at Isaac.
Fat Bat
Fat Bat
Slowly flies towards Isaac. Tries to align itself diagonally to Isaac and shoots at him when in that alignment.
Imp
Imp
Slowly drifts towards Isaac, frequently firing 5 blood shots in quick succession towards him. Tries to avoid Isaac's shots and occasionally teleports and reappears elsewhere.
Roundy
Roundy
Pops out of the ground in random locations, creating a small rock wave. Fires an explosive Ipecac shot at Isaac if he is in sight.
Black Bony
Black Bony
Wanders around the room and throws three bones in a row at Isaac when he is in sight. Explodes upon death.
Black Globin
Black Globin
Chases Isaac, dealing a full heart of contact damage and spawning Spiders whenever it takes damage. Spawns a Spider, a Black Globin's Head, and a Black Globin's Body upon death.
Black Globin's Head
Black Globin's Head
Slides towards Isaac, leaving a trail of damaging Red Creep.
Black Globin's Body
Black Globin's Body
Walks aimlessly around the room, occasionally spawning spiders.
Swarm Fly
Swarm Fly
Follows Isaac in large groups and deals contact damage.
Mega Clotty
Mega Clotty
Slowly moves around the room, occasionally hopping and either firing 6 blood shots in all directions, leaving a puddle of Red Creep, or spawning a Clotty or a collapsed Globin. Splits into two Clotties upon death.
Bone Knight
Bone Knight
Moves erratically around the room, charges toward Isaac when in line of sight, and leaves behind a short-lasting trail of damaging Red Creep. Can only be damaged from behind.
Cyclopia
Cyclopia
Walks towards Isaac, dealing contact damage and leaving behind a short-lasting trail of damaging Red Creep. Occasionally shoots a blood shot towards Isaac.
Red Ghost
Red Ghost
Disappears, then reappears near Isaac and fires a brimstone laser.
Flesh Death's Head
Flesh Death's Head
Moves diagonally around the room, dealing contact damage. Releases 6 blood shots in all directions upon death. Can be killed, but also dies when the room is cleared.
Mom's Dead Hand
Mom's Dead Hand
Falls from the ceiling. Upon landing, it spawns several rock waves that travel outwards. Spawns several spiders upon death. Entering a room containing Mom's Dead Hand will warn the player with Mom's laugh.
Dukie
Dukie
Flies around the room diagonally, occasionally spitting out 1-2 Dart Flies.
Ulcer
Ulcer
Pops out of the ground in random locations and spawns a Dart Fly if Isaac is in sight. Fires a blood shot after spawning 6 Dart Flies.
Meatball
Meatball
Slides around the room. If Isaac is in sight, it will stop to spew a fountain of short-range blood shots in all directions or to spit a line of damaging Red Creep towards Isaac. Spawns a Host upon death.
Pitfall
Pitfall
Invulnerable and stationary enemy which Isaac falls into when walked over, taking damage and popping back out after a short delay.
Teleport Pitfall
Teleport Pitfall
Invulnerable and stationary enemy which Isaac falls into when walked over, taking damage and popping back out at a random location after a short delay.
Suction Pitfall
Suction Pitfall
Invulnerable and stationary enemy which sucks Isaac towards itself. Isaac falls into it when walked over, taking damage and popping back out after a short delay.
Ultra Greed Coin (Spinner)
Ultra Greed Coin (Spinner)
Spins around the room, dealing contact damage.
Ultra Greed Coin (Key)
Ultra Greed Coin (Key)
Spins on itself and opens a golden door around the room if not destroyed.
Ultra Greed Coin (Bomb)
Ultra Greed Coin (Bomb)
Spins on itself and explodes with a large radius if not destroyed.
Ultra Greed Coin (Heart)
Ultra Greed Coin (Heart)
Spins on itself and heals Ultra Greed for 13.125 HP each if not destroyed.
Corn Mine
Corn Mine
Goes off when destroyed or after some time, then releases a cloud of poisonous gas and fires corny shots in eight directions.
Hush Fly
Hush Fly
Gathers with other Hush Flies and flies towards Isaac in certain patterns. Can also orbit Hush.
Blue Gaper
Blue Gaper
Walks towards Isaac, dealing contact damage.
Blue Boil
Blue Boil
Stationary enemy that decreases in size when hit, but regenerates to its full size until fully destroyed. Fires 1-3 blood shots towards Isaac when fully swollen.
Greed Gaper
Greed Gaper
Walks towards Isaac, dealing contact damage.
Dark Ball
Dark Ball
Floats towards Isaac, doing contact damage.

Bosses[edit | edit source]

Boss Rag Man.png
Boss Little Horn.png
Boss Dangle.png
Boss Turdlings.png
Rag Man Little Horn Dangle Turdlings
Boss The Frail.png
Boss The Stain.png
Boss The Forsaken.png
Boss Brownie.png
The Frail The Stain The Forsaken Brownie
Boss Hush.png
Boss Ultra Greed.png
Hush Ultra Greed

Beggars[edit | edit source]

Bomb Bum.png Bomb bum

Bomb Bums are extremely rare, and ask for bombs. Each bomb donated has a chance to have him drop 1-2 bomb pickups or an item from the Bomb Bum Item Pool. After spawning a pedestal item, the Bomb Bum will disappear and can no longer be donated to.

Environment[edit | edit source]

Chapters[edit | edit source]

Burning Basement Flooded Caves
Burning Basement Flooded Caves
Dank Depths Scarred Womb
Dank Depths Scarred Womb
???
??? (Blue Womb)

Challenges[edit | edit source]

Name Conditions Goal Unlocked by Unlocks


23. Blue Bomber
???
Full soul heartFull soul heartFull soul heartFull soul heart
Blindfolded.png Blindfolded
Starts with:
Brother Bobby Brother Bobby
Kamikaze! Kamikaze!
Pyromaniac Pyromaniac
Mr. Mega Mr. Mega
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Satan.png Blue Bomber Destroy 10 Tinted Rocks and defeat Mom's Heart 11 times Gold Bomb Gold Bomb
27. BRAINS!
???
Full soul heartFull soul heartFull soul heartFull soul heart
Blindfolded.png Blindfolded
Starts with:
3 Bob's Brain Bob's Brain
Thunder Thighs Thunder Thighs
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
??? BRAINS! Defeat Isaac 5 times Stud Finder Stud Finder
25. Have a Heart
Isaac
Starts with:
Charm of the Vampire Charm of the Vampire
Item Pool Treasure Room.png: yes
Item Pool Shop.png: yes
Pennies drop instead of Red Hearts. Many items that restore Red Hearts have no effect.
Boss Mom's Heart.png / Boss It Lives.png Have a Heart Defeat Mom 2 new pills 2 new pills
26. I RULE!
Isaac
Full red heartFull red heartFull red heart
Starts with:
The Boomerang The Boomerang
Key Piece 1 Key Piece 1
Key Piece 2 Key Piece 2
The Ladder The Ladder
Mom's Knife Mom's Knife
Trinity Shield Trinity Shield
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mega Satan.png I RULE! Defeat ??? or The Lamb, and defeat Satan as Isaac Poker Chip Poker Chip
29. Onan's Streak
Judas
Full red heart
Starts with:
The Book of Belial The Book of Belial
Chocolate Milk Chocolate Milk
Item Pool Treasure Room.png: yes
Item Pool Shop.png: yes
Missing a shot deals damage to Judas.
Isaac Onan's Streak Defeat Mom Kidney Stone Kidney Stone
24. PAY TO PLAY
Isaac
Full red heartFull red heartFull red heart
Starts with:
Money = Power Money = Power
Sack of Pennies Sack of Pennies
50 coins
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Every door costs 1 cent to enter. Isaac drops money when hit. Isaac dies if he run out of money.
Isaac PAY TO PLAY Defeat Isaac as Cain 2 new pills 2 new pills
28. PRIDE DAY!
Isaac
Full red heartFull red heartFull red heart
Starts with:
3 Dollar Bill 3 Dollar Bill
Rainbow Baby Rainbow Baby
Added in AfterbirthRainbow Worm Rainbow Worm
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Cannot drop or replace Rainbow Worm.
Boss Mom's Heart.png / Boss It Lives.png PRIDE DAY! Defeat Mom D8 D8
22. SPEED!
Isaac
Full red heartFull red heartFull red heart
Item Pool Treasure Room.png: yes
Item Pool Shop.png: yes
Everything is sped up like the Broken Watch effect.
Boss Mom's Heart.png / Boss It Lives.png
within 16 minutes, otherwise under constant periodic damage every 10 seconds.
SPEED! Defeat Mom Get out of Jail Free Card Get out of Jail Free Card
30. The Guardian
Isaac
Full red heartFull red heartFull red heart
Blindfolded.png Blindfolded
Starts with:
Holy Grail Holy Grail
Isaac's Heart Isaac's Heart
Punching Bag Punching Bag
Added in AfterbirthSpear of Destiny Spear of Destiny
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Isaac's Heart will follow Punching Bag Punching Bag instead of Isaac.
Boss Mom's Heart.png / Boss It Lives.png The Guardian Defeat Mom Blank Rune Blank Rune
21. XXXXXXXXL
Isaac
Full red heartFull red heartFull red heart
Item Pool Treasure Room.png: yes
Item Pool Shop.png: yes
Every floor is the size of an XL Womb floor, but does not combine the floors of each chapter.
Boss Mom's Heart.png / Boss It Lives.png XXXXXXXXL Defeat Mom Gold Heart Gold Heart

Changes[edit | edit source]

Player[edit | edit source]

Characters[edit | edit source]

Azazel
  • His mini-brimstone's range can be increased with range up items or pills.
The Lost

Items[edit | edit source]

Activated Collectibles[edit | edit source]

Bob's Rotten Head Bob's Rotten Head
  • The head deals 3 times Isaac's tear damage as poison over time instead of either 6 or 8 points.
The Book of Belial The Book of Belial
  • Increases the chance to open the Devil Room or Angel Room by 12.5% after killing a boss while holding it instead of guaranteeing it.
Book of Revelations Book of Revelations
  • Increases chance for a Devil/Angel Room Door to open by 17.5% instead of 35%.
Butter Bean Butter Bean
  • Knocks back enemy shots.
Crack the Sky Crack the Sky
  • The beams have a high chance to directly target enemies.
D4 D4
  • Previously held items are removed from the pause menu.
The D6 The D6
  • Reroll an item after defeating The Fallen no longer replace the Devil Room item he drops to a random item from the normal boss item pool.
D10 D10
  • Fly enemies are only rerolled into other fly enemies.
  • Red flies can't be rerolled anymore (even though enemies can be rerolled into them).
Flush! Flush!
  • Floods the whole room with water.
  • Flushes all poop-related enemies and bosses away.
  • The ladders are covered in water but the walls are not when used inside a crawl space.
Guppy's Paw Guppy's Paw
  • Can no longer be used without red heart containers.
Head of Krampus Head of Krampus
  • Has a 50% chance to rotate all beams around the player 90 degrees, similar to Krampus' second Brimstone attack.
The Jar The Jar
  • Sprite changed.
Monstro's Tooth Monstro's Tooth
  • Does not affect if Monstro is in the room the item is used in.
The Poop The Poop
  • Knocks back enemy shots.
Scissors Scissors
  • Its recharge time is 2 rooms instead of 6 rooms.
Undefined Undefined
  • Dark Room can no longer be cleared repeatedly.

Passive Collectibles[edit | edit source]

20/20 20/20
  • Sprite changed.
3 Dollar Bill 3 Dollar Bill
  • The type of randomized tear changes every 2–3 seconds. The item appears to select two tear effects at once, perhaps staggering the times at which each of those effects change.
  • If a run is quit, and then continued, 3 Dollar Bill will keep tear effects for the current room.
Abel Abel
  • Shoots tears towards Isaac regardless of which direction Isaac is shooting.
Ball of Bandages Ball of Bandages
  • Blocks enemy shots.
Bob's Brain Bob's Brain
  • Bob's Brain is fired directly from where it is located in the chain of familiars behind Isaac, making aiming it slightly more difficult.
  • Each copy takes up its own spot on the familiar line, but only the first one launches out. Respawning brains may end up stacking on top of each other.
Bomb Bag Bomb Bag
Box Box
Butt Bombs Butt Bombs
Cain's Other Eye Cain's Other Eye
  • Each tear deals Isaac's tear damage.
The Common Cold The Common Cold
  • The poison hits twice, dealing a total of double Isaac's damage.
Dr. Fetus Dr. Fetus
  • Each bomb deals 5 times the character's normal tear damage instead of 3, plus a flat 30 damage. The flat 30 is not affected by damage multipliers.
Fire Mind Fire Mind
  • Isaac gives a wide glow lighting up dark areas, such as those under the effects of the Curse of Darkness or the Dark One's attacks.
Isaac's Heart Isaac's Heart
  • Brimstone shots damage the heart.
Leo Leo
  • Nullifies effects of One Makes You Small pills, One Makes You Larger pills, and other items that decrease the size of Isaac, such as Caffeine Pill.
Lost Contact Lost Contact
  • Gives a shield to familiar's tears.
Lord of the Pit Lord of the Pit
  • Speed boost is applied immediately.
Mom's Contacts Mom's Contacts
  • Range and tears height buffs are applied immediately.
Mom's Knife Mom's Knife
  • If picked up twice in the same run, two knives are fired at once.
Punching Bag Punching Bag
  • Dies after taking too much damage and then respawns after a long time. Exiting and continuing the run will cause it to reappear right away.
  • Dies instantly by enemies' beam-type attacks, such as Uriel's and Gabriel's beam. This also includes enemies' Technology lasers such as Eye and Camillo Jr..
  • Reappears instantly each time a familiar or orbital item is picked up.
Scorpio Scorpio
  • The poison hits twice, dealing a total of double Isaac's damage.
Steam Sale Steam Sale
  • Having multiple Steam Sales reduces all shop prices to 0 coins.
  • Causes the Deals with the Devil not to convert the heart-type automatically.
Stop Watch Stop Watch
  • The slow is only applied after the player is hit.
Strange Attractor Strange Attractor
  • Isaac's bombs are magnetically attracted to the player character's tears.
Tech.5 Tech.5
The Virus The Virus
  • Each poison hit deals damage equal to Isaac's tear damage instead of 4 or 6 damage.
  • Enemies killed after they have been inflicted with this type of poison have a 20% chance to drop Black Hearts.

Trinkets[edit | edit source]

Match Stick Match Stick
  • Can replace the Tick.
Missing Poster Missing Poster
  • No longer displays a particular puzzle piece on the last will screen if Isaac dies in a Sacrifice Room while holding it.
  • Dying in a Sacrifice Room while holding it unlock The Lost, regardless of the current character.
    • If The Lost was already unlocked, Isaac will be revived as The Lost and Missing Poster will be consumed.
    • If the player's character is already The Lost, he will be revived in the previous room and Missing Poster will be consumed.
Mysterious Paper Mysterious Paper
Tick Tick

Interactions[edit | edit source]

* 20/20 20/20 + Brimstone Brimstone - Two brimstone shots are fired, without an increase in charge time.

Pickups[edit | edit source]

Bombs[edit | edit source]

Troll Bomb
  • Troll Bombs are now given a random amount of time before exploding. Before that, they always exploded at a fixed time. This means that if two Troll Bombs spawn at the exact time right next to each other, there's a high chance one Troll Bomb will blow up before the other, sending that Troll Bomb sliding outwards a bit before exploding.

Entities[edit | edit source]

Monsters[edit | edit source]

Bony
  • Only leaves behind bones when killed.

Environment[edit | edit source]

Rooms[edit | edit source]

Boss Room
  • Double Trouble boss rooms can now contain 2 bosses of different types. Additionally, they can appear as early as chapter 1.
Arcade

Arcade 12.pngArcade 13.pngArcade 14.pngArcade 15.png

Angel Room
  • Possible rewards found in the room include:
  • Urns might spawn in the room.
  • Killing Key Key Master and Shell Game Beggar no longer applies the 25% bonus.
  • Donating to a Beggar until it pays out with an item on the current floor applies a 10% bonus instead of 25%.
  • Donating to a Devil Beggar until it pays out with an item on the current floor applies a 10% bonus instead of 25%.
    • If this coin flip succeeds, a Devil Room will be generated regardless of the above coin flips.
  • "You feel blessed!" fortune in the Sacrifice Room of the current floor applies a bonus:
    • If the "You feel blessed!" fortune appeared on the 3rd sacrifice, the chance will be 15%.
    • If the "You feel blessed!" fortune appeared on the 5th sacrifice, the chance will be 50%.
    • If both "You feel blessed!" fortunes appeared, the chance will be 65%.
  • Angel Rooms that spawn after Isaac defeats Mom's Heart or It Lives will be normal Angel Rooms with items or pickups.
  • A Troll Bomb can sometimes appear behind the Angel Statue, blowing it up. If the Angel fights have been unlocked, this will begin the boss fight if the player is not careful or quick enough to move the bomb.
Bedroom
  • The clean bedroom occasionally has two clean beds instead of one.
  • The trapdoor in a dirty bedroom has a chance to lead to a Crawl Space.
  • Occasionally, one Rag Man will spawn inside the dirty bedroom.
Boss Rush

Boss Rush 2.pngBoss Rush 3.pngBoss Rush 4.pngBoss Rush 5.png

  • If a sack spawns for whatever reason, picking it up will start the Boss Rush. The player can still pick up one of the pedestal items.
Black Market
  • Black Market can no longer be accessed in The Chest and The Dark Room, and therefore cannot be used to collect more items.
Curse Room
Challenge Room
  • The three waves appear in random orders rather than the original orders.
Sacrifice Room
  • The payouts only depend on the number of sacrifices made. The number of sacrifices is reset to 0 when the player goes to the next floor.
  • Rewards are reworked:
№ of sacrifices on Current Floor Chance Reward
1st/2nd 50% Nothing
50% 1 Penny
3rd 33% Nothing
67% "You feel blessed!" (increased chance to receive an Angel Room over a Devil Room for the current floor)
  • Does not increase the chance of a Devil/Angel room after defeating a boss, only the chance of getting an Angel Room over a Devil Room.
  • Can cause an Angel Room to spawn even if you already took a deal with the devil.
  • Less of a modifier than the "You feel blessed!" effect below.
4th 50% Nothing
50% 1 random chest (The type of chest is governed by the same mechanic as room drops. Thus, brown chests are more likely to spawn than any other kind of chest.)
5th 33% 3 Pennies (These coins do not have a chance to spawn as a nickel or a dime.)
67% You feel blessed!" (Same conditions as 3rd sacrifice but a stronger modifier.)
6th 33% Teleport to the Devil/Angel Room. (If the floor's Devil/Angel Room has not been entered yet, an Angel Room is guaranteed to spawn — even if you already took a Devil Deal.)
67% 1 random chest (The type of chest is governed by the same mechanic as room drops. Thus, brown chests are more likely to spawn than any other kind of chest.)
7th 33% 1 random Angel Room pedestal item.
67% 1 Soul Heart
8th 100% 6 Troll Bombs
9th 100% Uriel battle
10th 50% 7 Soul Hearts
50% 30 Pennies
11th 100% Gabriel battle
12th and onwards 50% Nothing
50% Teleport directly to the Dark Room
  • Losing red hearts due to the spikes will reduce the chance for a Devil Room to appear.
  • The amount of luck that the player has does not affect the payout probabilities.
  • Angels are normally able to fly over spikes, but will take damage from sacrifice room spikes.
  • New layouts:

Sacrifice Room 2.pngSacrifice Room 3.pngSacrifice Room 4.pngSacrifice Room 5.png

Secret Room
Shop
  • There is a small chance when you bomb the Shopkeeper that they can turn into Greed and start attacking you.
Super Secret Room
Treasure Room
  • There's a rare chance that a treasure room might contains two items to choose from, only one of which can be taken.
  • Treasure rooms may also contain a Restock Machine, allowing Isaac to re-roll offered items if he has coins or bombs.
  • New layouts:

Treasure Room 13.pngTreasure Room 14.pngTreasure Room 15.pngTreasure Room 16.pngTreasure Room 17.pngTreasure Room 18.pngTreasure Room 19.pngTreasure Room 20.pngTreasure Room 21.pngTreasure Room 22.pngTreasure Room 23.pngTreasure Room 26.pngTreasure Room 27.pngTreasure Room 28.pngTreasure Room 31.pngTreasure Room 32.pngTreasure Room 33.pngTreasure Room 34.pngTreasure Room 35.pngTreasure Room 36.pngTreasure Room 37.pngTreasure Room 38.pngTreasure Room 39.pngTreasure Room 24.pngTreasure Room 30.pngTreasure Room 25.pngTreasure Room 29.png

Other[edit | edit source]

  • When not having red hearts in Devil Room, the price of items switches to soul hearts.
  • Krampus has a new attack pattern.
  • The floor icons on the stage transition sprites are updated; instead of being large rectangles with the unknown ones being grey, the sprites feature a much thinner and more detailed border with the unknown floors being represented by a closed trap door.

Gallery[edit | edit source]

Trivia[edit | edit source]

  • Afterbirth is the placenta and fetal membranes discharged from the uterus after the birth of offspring, which might be why the title screen is bloody.



Collectible Broken Modem icon.png Version History Collectible Broken Modem icon.png
Rebirth v0.9, v1.0, v1.01, v1.02, v1.031, v1.032, v1.04, v1.041, v1.05 (Hotfix)

Afterbirth
v1.06, v1.06 Hotfix, v1.06.0051, v1.06.0052, v1.06.0059, v1.06.0060, v1.06.0067, v1.06.0076, v1.06.0109

Afterbirth †
v1.06.0180, v1.06.0181, v1.06.0182, v1.06.0183, v1.06.0185, v1.06.0187, v1.06.0188, v1.06.0190, v1.06.0192 (Re-release), v1.06.0193, v1.06.0211
Booster Pack #1 v1.06.J34, v1.06.J39
Booster Pack #2 v1.06.J75, v1.06.J85
Booster Pack #3 v1.06.J99, v1.06.J103, v1.06.J104
Booster Pack #4 v1.06.J113, v1.06.J114, v1.06.J119, v1.06.J127
Booster Pack #5 v1.06.J149, v1.06.J150, v1.06.J168
The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth
Achievements Achievements Attributes Attributes Bosses Bosses TarotCard.png Cards and Runes Challenges Challenges Chapters Chapters
Characters Characters MainPageBabies.png Co-op Items Items Item pools Item pools Monsters Monsters Objects Objects
Pickups Pickups Pills Pills Rooms Rooms Seeds Seeds Transformations Transformations Trinkets Trinkets