The D6

The D6 is a Special unlockable activated item.

Effect

Upon use, replaces every item in the current room (not pickups or trinkets) with other random items corresponding to the current room's item pool.

Notes

Isaac starts with this item once it is unlocked.
Since it rerolls every item in the room, it can be convenient to use it in rooms where multiple items are in the same room. For instance:
- In the Shop, when multiple items are available for purchase.
- In the Devil Room, when there are multiple deals offered.
- In the Boss Room after the Mom fight, where both The Polaroid and The Negative can be rerolled, at the cost of the opportunity to go to the Chest/Dark Room. Once one item is picked up the other will disappear.
- In the Boss Rush Room, where all 4 items can be rerolled at once.
- When There's Options or More Options spawn two items.
Items from chests can be rerolled.
When an item pool is exhausted, every item will be rerolled to Breakfast.
If Isaac runs out of red hearts in the Devil Room, then rerolls, the prices of the items switch over to soul hearts.
Using the D6 on an active item yields different rerolls depending on whether you picked up the active item first.
Using the D6 to reroll items duplicated with Diplopia will reroll all the items into different items. The copied item will not be rerolled into the same one as the original item.
With Sharp Plug and any combination of items that can infinitely regenerate health, the D6 can be used to reroll items indefinitely.
Be careful when rerolling, as it will replace the item with another item from the current room's item pool. This can be used as an advantage in various ways; for example, after defeating The Fallen, the item will be drawn from the Devil Room pool, so Isaac can safely roll the item and also items dropped by beggars in this room will be rolled into devil deal items. This behavior can also be an advantage in Angel Rooms since Key Piece 1 and Key Piece 2 can be rerolled to get a free Angel Room item.

Interactions

Car Battery: Re-rolls twice instantly without any benefits.

In-game Footage

Gallery

3DS The icon of The D6 as seen on the lower 3DS screen

Trivia

Although the D6 is considered a Special Item, it will only count as a special item if found naturally during gameplay. Starting with the D6 as Isaac will not cause fewer special items to appear later on. This fact also extends to Eden's starting items: if Eden starts with a special item, that item will not count toward the special item total.
In the original Binding of Isaac, the D6 had a recharge time of 3 instead of 6.
- The D6 could not reroll special boss items in the original game, such as Little C.H.A.D. and Little Steven.
In the Eternal Edition of the original Binding of Isaac, The D6 has a chance to delete the item instead of rerolling it when playing in hard mode.