The Host

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The Host
Challenge number
18
Character
Isaac App.png
Full red heartFull red heartFull red heart
Starting Items
The Mulligan The MulliganThe Mulligan Icon.pngTears have a 1/6 chance of spawning allied blue flies when they hit an enemy.
Spider Baby Spider BabySpider Baby Icon.pngWhen hit, spawns up to 2 blue spiders.
Trinket:
Tick TickTick Icon.pngDrain 15% health of each enemy with more than 60 HP (ie. most bosses). Also restores one red heart of Isaac whenever he enters an uncleared boss room. The Tick cannot be swapped out for another trinket.
Available rooms
Item Pool Treasure Room.png: no          Item Pool Shop.png: yes
Goal
Boss Mom.png
Unlocks
Technology .5 Technology .5Technology .5Complete challenge #18

The Host is Challenge #18, starting with the items Spider Baby Spider BabySpider Baby Icon.pngWhen hit, spawns up to 2 blue spiders., The Mulligan The MulliganThe Mulligan Icon.pngTears have a 1/6 chance of spawning allied blue flies when they hit an enemy., and the Tick TickTick Icon.pngDrain 15% health of each enemy with more than 60 HP (ie. most bosses). Also restores one red heart of Isaac whenever he enters an uncleared boss room. The Tick cannot be swapped out for another trinket. trinket. The goal is to defeat Mom. This Challenge is unlocked by default.

Difficulty[edit | edit source]

  • Isaac starts with the Tick TickTick Icon.pngDrain 15% health of each enemy with more than 60 HP (ie. most bosses). Also restores one red heart of Isaac whenever he enters an uncleared boss room. The Tick cannot be swapped out for another trinket., meaning picking up other trinkets is impossible without Mom's Purse Mom's PurseMom's Purse Icon.pngAllows Isaac to hold 1 additional trinket. or Added in Afterbirth †Belly Button Belly ButtonBelly Button Icon.pngDrops a random trinket. Grants a second trinket slot..
    • Added in Afterbirth It is also removable using the Match Stick Match StickMatch Stick Icon.pngIncreases the chance of Bombs dropping after clearing a room, and the chance of finding Bombs when opening a Chest..
    • Added in Afterbirth † A Gulp pill or Added in Afterbirth †Smelter SmelterSmelter Icon.png6 roomsConsumes Isaac's currently held trinket and applies its effect permanently. can also be used to ingest the Tick.

Strategy[edit | edit source]

  • Shops can sell Mom's Purse Mom's PurseMom's Purse Icon.pngAllows Isaac to hold 1 additional trinket., which will allow a second trinket.
  • Shops can also sell Hive Mind Hive MindHive Mind Icon.pngIncreases the size of blue spiders and Blue Flies and doubles the amount of damage they deal., which will make blue flies and blue spiders bigger and stronger.
  • Shops can also sell Added in Afterbirth †Smelter SmelterSmelter Icon.png6 roomsConsumes Isaac's currently held trinket and applies its effect permanently., which will allow the tick to be smelted and new trinkets to be picked up.

Reward[edit | edit source]

Trivia[edit | edit source]

  • A host is an organism that is infected by a parasite, which explains why Isaac has items and trinkets relating to parasites.
  • This challenge is similar to the 'Lord of the Flies' challenge in the original game.


MainPageChallenges.png Challenges MainPageChallenges.png

Rebirth
1. Pitch Black 2. High Brow 3. Head Trauma 4. Darkness Falls 5. The Tank 6. Solar System 7. Suicide King 8. Cat Got Your Tongue
9. Demo Man 10. Cursed! 11. Glass Cannon 12. When Life Gives You Lemons 13. Beans! 14. It's in the Cards 15. Slow Roll 16. Computer Savvy
17. Waka Waka 18. The Host 19. The Family Man 20. Purist
Afterbirth
21. XXXXXXXXL 22. SPEED! 23. Blue Bomber 24. PAY TO PLAY 25. Have a Heart 26. I RULE! 27. BRAINS! 28. PRIDE DAY!
29. Onan's Streak 30. The Guardian
Afterbirth †
31. Backasswards 32. Aprils Fool 33. Pokey Mans 34. Ultra Hard 35. Pong


The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth
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Red heart.png Pickups BlueBlue.png Pills MainPageRooms.png Rooms MainPageSeeds2.png Seeds Guppy App.png Transformations The Left Hand Icon.png Trinkets