The Nail is an unlockable activated item.
Effects
Gives one Soul Heart, +0.7 damage, -0.18 speed, and the ability to destroy most obstacles by walking into them. Cannot be stacked in one room.
- Isaac deals 40 contact damage to enemies, once per second. Does not prevent Isaac from taking contact damage.
- Gives half a Black Heart, +2 damage, -0.18 speed and the ability to destroy obstacles for the current room.
- If used multiple times in one room, the speed penalty only applies once, but the damage buff can stack.
- Isaac deals 20 contact damage to enemies, twice per second. Does not prevent Isaac from taking contact damage.
- If an enemy is at 40 HP or less, the contact damage is increased to 40 for that enemy.
- Isaac's tears become red for the current room.
- This item belongs to the Leviathan set. Collecting three items from this set will transform Isaac into Leviathan.
Gives one 
Notes
- Isaac makes a demon sound when taking damage while this item is in use. This is quieter than Isaac's standard damage sound and is easy to miss.
Synergies
- Book of Virtues: Spawns black wisps on the inner ring. Wisps shoot nails that deal double damage from standard wisps, and have increased knockback, akin to 8 Inch Nails.
In-game Footage
Gallery
3DS The icon of The Nail as seen on the lower 3DS screen.
Trivia
- The item's effect is a reference to the Nail of Vlad item in Castlevania II: Simon's Quest; equipping it would allow Simon to break certain obstacles such as rocks.
- In the original The Binding of Isaac, The Nail was unlocked by beating Mom's Heart three times.
- This item has the same pickup quote as Sulfur.
- Biblically, this item likely references the nails used to pin Jesus Christ to the cross.
 Azazel Unlocks
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 Boss Rush Unlocks
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 The Binding of Isaac: Rebirth
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