The Virus

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Font TeamMeat T.pngFont TeamMeat h.pngFont TeamMeat e.png   Font TeamMeat V.pngFont TeamMeat i.pngFont TeamMeat r.pngFont TeamMeat u.pngFont TeamMeat s.png
Item icon
Item altar
 
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13
 
Character appearance
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Devil Beggar Devil Beggar
Treasure Room Treasure Room
Greed mode only Treasure Room Treasure Room
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Added in Afterbirth(page 1, column 13, row 1)
Removed in Afterbirth(page 1, column 3, row 2)

The Virus is a passive item.

Effects[edit | edit source]

  • Inflicts poison on enemies who make contact with Isaac.
    • The poison randomly hits either 2 or 3 times, dealing a total of 4 or 6 damage.
      • Added in Afterbirth Each poison hit deals damage equal to Isaac's tear damage.
    • Added in Afterbirth Enemies who are killed after they have been inflicted with this type of poison have a 20% chance to drop black hearts.
  • -0.1 Speed down (Removed in Afterbirth not applied until the next time Isaac's speed stat is updated)
  • Added in Afterbirth This item belongs to the SpunSpun App.pngGives +2 damage and +0.15 speed, and spawns a random pill upon transformation. set. Collecting three items from this set will transform Isaac into a buff berserker.

Notes[edit | edit source]

  • The black heart is only dropped if the poison was caused by The Virus. The item's effect doesn't extend to poison tears.
  • If an enemy doesn't do contact damage, The Virus can safely be applied to it for more chances at black hearts. Black flies, Mulligans, and Hosts are the most common enemies this can be applied to.
    • With Skatole SkatoleSkatole Icon.pngAll types of fly except Boom Fly and Red Boom Fly become passive and slowly move towards Isaac. Does not prevent contact damage., Hives and Swarmers will constantly spawn black flies, meaning they can be endless sources of black hearts.
    • Removed in Afterbirth † Although Stonies and Shopkeepers can't be visibly poisoned, they still can drop Black Hearts if destroyed after being touched.
  • Enemies won't start taking poison damage if they are pushing up against Isaac; The Virus will be constantly trying to apply poison and refreshing the ticks where poison damage would occur.
    • Gnawed Leaf Gnawed LeafCollectible Gnawed Leaf icon.pngAfter standing still and not shooting for a short time, Isaac turns invincible until he moves or shoots. and The Virus can still work if Isaac has a short-range orbital such as Cube of Meat Cube of MeatCollectible Cube of Meat icon.pngOrbiting familiar that blocks enemy shots and deals damage to enemies. If collected while already having one, it makes the familiar evolve. Only drops from Horsemen. Similar to Ball of Bandages. or Ball of Bandages Ball of BandagesCollectible Ball of Bandages icon.pngOrbiting familiar that deals damage to enemies. If collected while already having one, makes the familiar evolve. Only drops from Horsemen. Similar to Cube of Meat., as it will kill enemies pushing against Isaac that are not taking poison damage while still dropping black hearts.

In-game Footage[edit | edit source]

Synergies[edit | edit source]

  • Any item or card that grants Isaac temporary invincibility lets Isaac apply The Virus onto any enemy without taking damage. This includes, but is not limited to:
    • A Pony A PonyCollectible A Pony icon.png4 roomsPassively grants flight and increased speed. Upon use, Isaac charges in the direction the pony is facing, becoming invulnerable during the charge and damaging enemies. /White Pony White PonyCollectible White Pony icon.png6 roomsPassively grants flight and increased speed. Upon use, Isaac charges in the direction the pony is facing, becoming invulnerable during the charge and damaging enemies while also casting the effect of Crack the Sky.
    • Book of Shadows Book of ShadowsCollectible Book of Shadows icon.png3 roomsUpon use, creates a protective shield nullifying all types of damage for 10 seconds.
    • Breath of Life Breath of LifeCollectible Breath of Life icon.png6 secondsGrants a brief moment of invincibility when the charge bar hits zero. If the spacebar is held for an additional second after hitting zero, Isaac will take damage.
    • Celtic Cross Celtic CrossCollectible Celtic Cross Rebirth icon.pngGrants a chance to trigger the Book of Shadows effect upon taking damage, creating a shield that nullifies all types of damage for 7 seconds.
    • Gnawed Leaf Gnawed LeafCollectible Gnawed Leaf icon.pngAfter standing still and not shooting for a short time, Isaac turns invincible until he moves or shoots.
    • Holy Mantle Holy MantleCollectible Holy Mantle icon.pngAutomatically negates first taken damage in every room.
    • My Little Unicorn My Little UnicornCollectible My Little Unicorn icon.png6 roomsUpon use, grants invulnerability and increased speed for five seconds, removing the ability to shoot tears and replacing it with the ability to deal contact damage to enemies.
    • Taurus TaurusTaurus Rebirth Icon.pngSpeed down; gains speed while in a room with enemies until gaining My Little Unicorn effect for a few seconds.
    • The Gamekid The GamekidCollectible The Gamekid icon.png6 roomsUpon use, turns the character into a into a Pac-Man-like creature for 5 seconds, granting invulnerability, inflicting fear on all enemies, and replenishing half a red heart container for every two enemies killed.
    • The Polaroid The PolaroidCollectible The Polaroid icon.pngIf the character has half a red heart or no red hearts after taking damage, it triggers the Book of Shadows effect, creating a shield that nullifies all types of damage for 5 seconds. Also allows entrance into The Chest.
    • Unicorn Stump Unicorn StumpCollectible Unicorn Stump icon.png1 roomsUpon use, grants invulnerability and increased speed for five seconds, but removes the ability to shoot tears.
    • Virgo VirgoCollectible Virgo icon.pngGrants a chance to trigger the Book of Shadows effect upon taking damage, creating a shield that nullifies all types of damage for 10 seconds. Also converts "bad pills" into "good pills".
    • Added in AfterbirthEmpty Vessel Empty VesselCollectible Empty Vessel icon.pngWhile Isaac has no red hearts, this item grants flight and a random chance to activate an invincibility shield for a few seconds. If Isaac gains any red hearts, these benefits will disappear.
    • Added in AfterbirthVentricle Razor Ventricle RazorCollectible Ventricle Razor Afterbirth icon.pngUnlimitedCan be used to place an orange portal and a blue portal. Upon entering a portal, Isaac is teleported to the other portal. (briefly after exiting a portal)
    • Added in Afterbirth †Blanket BlanketCollectible Blanket icon.pngGrants one soul heart. Upon entering a boss room, grants a shield that blocks one hit, then disappears.
    • Added in Afterbirth †Dull Razor Dull RazorCollectible Dull Razor icon.png2 roomsHurts Isaac without depleting health, activating any items that trigger upon taking damage.
    • VII - The Chariot VII - The ChariotPickup VII - The Chariot icon.pngGrants the temporary invulnerability effect of My Little Unicorn.
    • Added in Afterbirth †Holy Card Holy CardPickup Holy Card icon.pngGrants the Holy Mantle effect for the current room.
    • Power Pill! pills
    • Feels like I'm walking on Sunshine! pills
    • Cartridge CartridgeCartridge Icon.pngChance to trigger The Gamekid effect upon taking damage.
    • Added in Afterbirth †Wooden Cross Wooden CrossTrinket Wooden Cross icon.pngGrants a Holy Mantle shield upon entering a new floor, which protects against one hit of damage.

Unlockable achievements[edit | edit source]

Trivia[edit | edit source]

  • Upon picking up The Virus, Isaac looks very similar to Lust, which is fitting since Lust also drops The Virus.

Seeds[edit | edit source]

 PC  26ND Z11A (Treasure room adjacent to spawn)

 PC  1389 DNH1 (Treasure room adjacent to spawn)

 PC  Added in Afterbirth † Normal and hard modes only FKVG 36FZ (Lust fight right of spawn)

 PS4  913D J63B (First floor treasure room)

 3DS  TKYD 8DRA (Treasure room adjacent to spawn)

 Switch  Greedier mode only FEKK E8JS (First Golden Treasure Room)


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