The Virus

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Item icon
Item altar
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Character appearance
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Added in Afterbirth(page 1, column 13, row 1)
Removed in Afterbirth(page 1, column 3, row 2)

The Virus is a passive item.

Effects[edit | edit source]

  • Inflicts poison on enemies who make contact with Isaac.
    • The poison randomly hits either 2 or 3 times, dealing a total of 4 or 6 damage.
      • Added in Afterbirth Each poison hit deals damage equal to Isaac's tear damage.
      • Added in Afterbirth † The poison hits a total of 6 times against normal enemies and 3 times against bosses. The effect can only be applied to bosses roughly every 6 seconds.
    • Added in Afterbirth Enemies who are killed after they have been inflicted with this type of poison have a 20% chance to drop Black Hearts.
  • -0.1 Speed down (Removed in Afterbirth not applied until the next time Isaac's speed stat is updated).
  • Added in Afterbirth This item belongs to the Spun set. Collecting three items from this set will transform Isaac into a buff berserker.

Notes[edit | edit source]

  • The black heart is only dropped if the poison was caused by The Virus. The item's effect doesn't extend to poison tears.
  • If an enemy doesn't do contact damage, The Virus can safely be applied to it for more chances at black hearts. Black flies, Mulligans, and Hosts are the most common enemies this can be applied to.
    • With Skatole Skatole, Hives and Swarmers will constantly spawn normal Flies, meaning they can be endless sources of Black Hearts.
    • Removed in Afterbirth † Although Stonies and Shopkeepers can't be visibly poisoned, they still can drop Black Hearts if destroyed after being touched.
  • Enemies won't start taking poison damage if they are pushing up against Isaac; The Virus will be constantly trying to apply poison and refreshing the ticks where poison damage would occur.
    • Gnawed Leaf Gnawed Leaf and The Virus can still work if Isaac has a short-range orbital such as Cube of Meat Cube of Meat or Ball of Bandages Ball of Bandages, as it will kill enemies pushing against Isaac that are not taking poison damage while still dropping Black Hearts.

Synergies[edit | edit source]

Interactions[edit | edit source]

  • Odd Mushroom Odd Mushroom: The speed down from the Virus does not stack with the Odd Mushroom; if both are collected, only a total of -0.1 applies.

In-game Footage[edit | edit source]

Unlockable Achievements[edit | edit source]

Trivia[edit | edit source]

  • Upon picking up The Virus, Isaac looks very similar to Lust, which is fitting since Lust also drops The Virus.
    • As such, The Virus may be a reference to an STI.

Seeds[edit | edit source]

PC 26ND Z11A (Treasure Room adjacent to spawn)

PC 1389 DNH1 (Treasure Room adjacent to spawn)

PC Added in Afterbirth † Normal and hard modes only FKVG 36FZ (Lust fight right of spawn)

PS4 913D J63B (First floor Treasure Room)

3DS TKYD 8DRA (Treasure Room adjacent to spawn)

Switch Greedier mode only FEKK E8JS (First Golden Treasure Room)

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