The Virus

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Font TeamMeat T.pngFont TeamMeat h.pngFont TeamMeat e.png   Font TeamMeat V.pngFont TeamMeat i.pngFont TeamMeat r.pngFont TeamMeat u.pngFont TeamMeat s.png
Item icon
Item altar
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Character appearance
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Devil Beggar Devil Beggar
Treasure Room Treasure Room
Greed mode only Treasure Room Treasure Room
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Added in Afterbirth(page 1, column 13, row 1)
Removed in Afterbirth(page 1, column 3, row 2)

The Virus is a passive item.

Effects[edit | edit source]

  • Inflicts poison on enemies who make contact with Isaac.
    • The poison randomly hits either 2 or 3 times, dealing a total of 4 or 6 damage.
      • Added in Afterbirth Each poison hit deals damage equal to Isaac's tear damage.
    • Added in Afterbirth Enemies who are killed after they have been inflicted with this type of poison have a 20% chance to drop black hearts.
  • -0.1 Speed down (Removed in Afterbirth not applied until the next time Isaac's speed stat is updated)
  • Added in Afterbirth This item belongs to the SpunSpun App.pngGives +2 damage and +0.15 speed, and spawns a random pill upon transformation. set. Collecting three items from this set will transform Isaac into a buff berserker.

Notes[edit | edit source]

  • The black heart is only dropped if the poison was caused by The Virus. The item's effect doesn't extend to poison tears.
  • Added in Afterbirth Black flies are the best source of black hearts, since they can't deal any damage, which means that you can poison them without losing health.
    • You can abuse this if you find a Skatole SkatoleSkatole Icon.pngAll types of fly except Boom Fly and Red Boom Fly become passive and slowly move towards Isaac. Does not prevent contact damage. item and a Hive enemy. This will result in an infinite source of black hearts.
    • Removed in Afterbirth † Although Stonies and Shopkeepers can't be visibly poisoned, they still can drop Black Hearts if destroyed after being touched.
  • Due to a glitch or patch, some enemies must be moving to receive poison damage. Some enemies pushing against Isaac that are immobile will not take damage, while the poisoned effect will still show up.
    • Gnawed Leaf Gnawed LeafCollectible Gnawed Leaf icon.pngAfter standing still and not shooting for a short time, Isaac turns invincible until he moves or shoots. and The Virus can still work if Isaac has a short range orbital such as Cube of Meat Cube of MeatCollectible Cube of Meat icon.pngOrbiting familiar that blocks enemy shots and deals damage to enemies. If collected while already having one, makes the familiar evolve. Only drops from Horsemen. Similar to Ball of Bandages. or Ball of Bandages Ball of BandagesCollectible Ball of Bandages icon.pngOrbiting familiar that deals damage to enemies. If collected while already having one, makes the familiar evolve. Only drops from Horsemen. Similar to Cube of Meat., as it will kill enemies pushing against Isaac that are not taking poison damage due to immobility while still dropping black hearts.

In-game footage[edit | edit source]

Synergies[edit | edit source]

  • Unicorn Stump Unicorn StumpCollectible Unicorn Stump icon.png1 roomsUpon use, grants invulnerability and increased speed for five seconds, but removes the ability to shoot tears.: While active, Isaac can run into enemies and poison them without getting hurt.

Unlockable achievements[edit | edit source]

Trivia[edit | edit source]

  • Upon picking up The Virus, Isaac looks very similar to Lust, which is fitting since Lust also drops The Virus.

Seeds[edit | edit source]

 PC  26ND Z11A (Treasure room adjacent to spawn)

 PC  1389 DNH1 (Treasure room adjacent to spawn)

 PC  Added in Afterbirth † Normal and hard modes only FKVG 36FZ (Lust fight right of spawn)

 PS4  913D J63B (First floor treasure room)

 3DS  TKYD 8DRA (Treasure room adjacent to spawn)

 Switch  Greedier mode only FEKK E8JS (First Golden Treasure Room)

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