Transformations

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Transformations
Guppy Beelzebub Added in Afterbirth  Super Bum Added in Afterbirth  Yes Mother Added in Afterbirth  Bob Added in Afterbirth  Fun Guy Added in Afterbirth  Leviathan Added in Afterbirth  Conjoined
Added in Afterbirth  Spun Added in Afterbirth  Seraphim Added in Afterbirth  Oh Crap Added in Afterbirth †  Bookworm Added in Afterbirth †  Spider Baby Added in Afterbirth †  Adult Added in Afterbirth †  Stompy

Transformations alter Isaac's appearance and grant him special abilities.

A transformation occurs when obtaining at least three collectibles from a particular set of items.
These collectibles always share a particular theme that corresponds with the transformation.

Transformation sets[edit | edit source]

The Binding of Isaac: Rebirth[edit source]

Transformation Appearance Transformation effect Item Icon Item effect Recharge
Beelzebub Beelzebub App.png
???'s Only Friend 320 ???'s Only Friend Controlled friend Summons a big attack fly that can be controlled with the shooting direction-keys.
Afterbirth †-exclusive content Angry Fly 511 Angry Fly He's violent Spawns a fly familiar that orbits around a random enemy and deals 2 damage per tick to enemies it comes in contact with.
BBF 272 BBF Big Beautiful Fly Spawns a familiar that flies around the room in a manner similar to the Boom Fly and explodes on contact with an enemy. Respawns after ten seconds.
Best Bud 274 Best Bud Sworn protector When hit, summons a white attack fly similar to Distant Admiration for the current room.
Big Fan 279 Big Fan Fat protector Spawns a large orbital familiar that blocks enemy projectiles and deals slight contact damage to enemies.
Distant Admiration 57 Distant Admiration Attack fly A red attack fly circles further out than the Halo of Flies / Pretty Flies, but closer than Forever Alone. Deals more damage than Forever Alone.
Forever Alone 128 Forever Alone Attack fly Spawns a blue attack fly that orbits a long distance from Isaac.
Halo of Flies 10 Halo of Flies Projectile protection Spawns two pretty fly familiars that block enemy shots and deal contact damage to enemies.
Hive Mind 248 Hive Mind Giant spiders and flies Increases the size of blue spiders and Blue Flies and doubles the amount of damage they deal.
Skatole 9 Skatole Fly love All types of fly except Boom Fly and Red Boom Fly become passive and slowly move towards Isaac. Does not prevent contact damage.
Smart Fly 264 Smart Fly Revenge fly After Isaac takes damage, this fly will deal continuous touch damage to whatever enemy caused the damage until it is dead. The fly will then systematically attack 1 enemy at a time until the room is cleared.
The Mulligan 151 The Mulligan They grow inside Tears have a 1/6 chance of spawning allied blue flies when they hit an enemy.
Infestation 148 Infestation They grow inside 1-3 Blue flies randomly spawn every time Isaac gets hit.
Afterbirth-exclusive content Friend Zone 364 Friend Zone Friendly fly A white orbiting fly which deals 3 contact damage per tick to enemies. This familiar orbits Isaac at a middle length distance somewhere between Distant Admiration and Forever Alone.
Afterbirth-exclusive content Lost Fly 365 Lost Fly Lost protector A familiar fly that moves in a straight line and attaches itself to the first obstacle or wall it comes into contact with in each room. If any enemies walk into its path, it will deal 7 contact damage per tick. If the obstacle it is attached to is destroyed then it will continue rolling in the direction it was previously travelling until it meets another wall or obstacle.
Afterbirth-exclusive content Papa Fly 430 Papa Fly Turret follower A blue fly familiar follows Isaac's movements on a 3 second delay. Papa Fly will fire tears at nearby enemies.
Afterbirth-exclusive content Obsessed Fan 426 Obsessed Fan Follows my every move... A purple fly familiar that follows Isaac's movements on a 3 second delay and deals contact damage to enemies.
Guppy! Guppy App.png
Guppy's Head 145
Guppy's Head
1 rooms
Reusable fly hive Spawns 2-4 blue flies to damage enemies.
Guppy's Paw 133
Guppy's Paw
Unlimited
Soul converter Removes one red heart container in exchange for gaining 3 Soul Hearts.
Dead Cat 81 Dead Cat 9 lives Sets the amount of red heart containers to 1, but gives Isaac 9 extra lives. After dying, Isaac is teleported to the last safe room. New heart containers can be obtained after picking up this item, but after each death, the number of heart containers is set to 1 again.
Guppy's Collar 212 Guppy's Collar Eternal Life? Grants Isaac a permanent 50% chance to respawn with 1/2 of a red heart after death.
Guppy's Tail 134 Guppy's Tail Cursed? Increases chance of finding gold chests and normal chests, but reduces chance of finding pickups.
Guppy's Hair Ball 187 Guppy's Hair Ball Swing it Loosely follows behind Isaac. Can be swung like a flail by rapidly spinning Isaac in a circle. Grows bigger by killing enemies.

The Binding of Isaac: Afterbirth[edit source]

Transformation Appearance Transformation effect Item Icon Item effect Recharge
Bob Bob Transformation.png
Bob's Rotten Head 42
Bob's Rotten Head
3 rooms
Reusable ranged bomb Upon use, Isaac holds a poison bomb which can be thrown towards any of the four cardinal points and explodes on impact.
Bob's Brain 273 Bob's Brain Explosive thoughts Spawns a familiar that charges forward when shooting tears, explodes upon contact with an enemy and poisons them. Respawns after few seconds.
Bob's Curse 140 Bob's Curse +5 poison bombs Gives 5 bombs and grants all bombs poison effect.
Ipecac 149 Ipecac Explosive shots Replaces tears with explosive and poisoning projectiles fired in an arc from the mouth.
Conjoined Baby Transformation.png
  • When attacking, the tumor faces shoot tears diagonally outwards, similar to the effect of The Wiz.
  • -0.3 damage.
  • Slightly decreases tears.
Brother Bobby 8 Brother Bobby Friends 'till the end Follows Isaac around shooting normal tears.
Harlequin Baby 167 Harlequin Baby Double shot buddy Spawns a familiar that follows Isaac around and fires two tears at once in a V-pattern.
Headless Baby 269 Headless Baby Bloody Friend Familiar that follows Isaac, leaving blood creep on the ground.
Little Steven 100 Little Steven Psychic friend Spawns a familiar that follows Isaac around and fires homing tears.
Mongo Baby 322 Mongo Baby Mongo Friend Summons a familiar that copies the tears of Isaac's other familiars.
Rotten Baby 268 Rotten Baby Infested friend A familiar that spawns blue flies.
Sister Maggy 67 Sister Maggy Friends 'till the end A familiar that follows Isaac around shooting blood tears.
Fun Guy Mushroom Transformation.png
Afterbirth-exclusive content God's Flesh 398 God's Flesh Shrink shot Tears now have a random chance to apply a shrinking effect, causing enemies to shrink in size and also run away from Isaac. Shrunk enemies can be crushed and killed by walking over them.
Mini Mush 71 Mini Mush Speed + range up Increases Speed and Shot Height and decreases Isaac's size, but lowers Range.
Magic Mushroom 12 Magic Mushroom All Stats Up! Increases all stats and enlargens Isaac.
Odd Mushroom 120 Odd Mushroom Fire rate up Increases Tears and Speed while reducing Damage.
Odd Mushroom 121 Odd Mushroom DMG up Grants an empty heart container. Increases damage, range and shot height while reducing speed.
1up! 11 1up! Extra life Gives an extra life. Upon death, you will respawn in the previous room with full health and lose the 1up!.
Blue Cap 342 Blue Cap HP + tears up + shot speed down Grants 1 heart container and increases tears, but decreases shot speed.
Leviathan Evil Angel Transformation.png
The Nail 83
The Nail
6 rooms
Temporary demon form Adds one soul heart and allows the breaking of rocks and damaging enemies by simply walking over them. Increases damage and decreases speed. All effects except for the Soul Heart wear off upon leaving the room.
The Mark 79 The Mark DMG up Increases Damage and Speed, plus adds one Soul Heart.
Missing Page 2 262 Missing Page 2 Evil up. Your enemies will pay! Gives 1 black heart. Upon taking damage that reduces Isaac's health to one heart or less, activates The Necronomicon effect, dealing 40 damage to all enemies in the room.
The Pact 80 The Pact DMG + Tears UP Increases damage by 0.5, tears by 0.7 and grants two soul hearts upon pickup.
Pentagram 51 Pentagram DMG up Increases damage and increases the chance for a Devil or Angel Room to appear.
Spirit of the Night 159 Spirit of the Night Scary Grants spectral tears and flight.
Afterbirth-exclusive content Maw of the Void 399 Maw of the Void Consume thy enemy! +1.0 Damage Up. After continuously firing tears for 2.5 seconds, a red cross appears on Isaac's head that, upon releasing the fire button, creates a black ring that rapidly deals damage equal to Isaac's tear damage to any enemies in contact with it.
Abaddon 230 Abaddon Evil + DMG up + fear shot Increases damage and speed, removes all red heart containers, grants six black hearts, and adds a chance to shoot fear tears.
Brimstone 118 Brimstone Blood laser barrage Tears are replaced by a laser beam that pierces through all enemies and obstacles in its path and deals high damage. Can only be fired after a short charge-up period.
Oh Crap Poop Transformation.png
  • Whenever a pile of poop is destroyed, health is replenished by half a heart.
Flush! 291
Flush!
6 rooms
... Changes all enemies in the room into poop. Does not work on all enemies (Knights and bosses are immune). Instantly kills Dingle, Dangle, and Brownie.
The Poop 36
The Poop
1 rooms
Plop! Spawns a pile of poop where the character is standing and knocks nearby monsters back. May yield pickups like regular poop.
E Coli 236 E Coli Turdy touch Gives "Turdy Touch" Effect. Enemies that touch Isaac are changed into poop.
Seraphim Angel Transformation.png
The Bible 33
The Bible
6 rooms
Temporary Flight Upon activation, Isaac gains flight, allowing him to pass over all obstacles in the current room. Instantly kills Mom, Mom's Heart, and It Lives when activated, but will kill Isaac when activated while fighting Satan.
Dead Dove 185 Dead Dove Flight + spectral tears Grants spectral tears and flight.
Guardian Angel 112 Guardian Angel Extra protection Spawns an orbital familiar that blocks enemy projectiles, deals contact damage to enemies, and increases the speed of all orbital familiars.
Holy Grail 184 Holy Grail Flight + HP up Grants flight and one heart container.
Holy Mantle 313 Holy Mantle Holy shield Automatically negates first taken damage in every room.
Mitre 173 Mitre You Feel Blessed Grants a chance of converting any red hearts pickups into soul hearts instead.
Rosary 72 Rosary Faith up Adds 3 Soul Hearts and increases the chance for The Bible to appear in any item pool.
Afterbirth-exclusive content Sworn Protector 363 Sworn Protector Protective friend An orbital angel which does 7 contact damage per tick and blocks enemy shots. When it blocks a shot, it has a very small chance to drop an eternal heart.
The Halo 101 The Halo All stats up Grants one Heart Container, +0.3 Damage, +0.2 Tears, +0.25 Range, +0.3 Speed, and +0.5 Tear Height.
Spun Drugs Transformation.png
Afterbirth †-exclusive content Adrenaline 493 Adrenaline Panic - power Increases damage based on how many empty heart containers Isaac has.
Afterbirth †-exclusive content Euthanasia 496 Euthanasia Needle shot Adds a chance to fire needles. If a needle kills an enemy, it bursts into more needles.
Experimental Treatment 240 Experimental Treatment All stats up, then shuffled Randomly increases and decreases some of the character's stats. There will always be at least one stat increase and one decrease and the same stats can be increased/decreased multiple times.
Growth Hormones 70 Growth Hormones Speed + DMG up Increases damage by 1 and speed by 0.4.
Roid Rage 14 Roid Rage Speed and range up Increases speed by 0.6, range by 5.25, and tear height by 0.5.
Speed Ball 143 Speed Ball Speed + shot speed up Increases speed by 0.3 and shot speed by 20%.
Synthoil 345 Synthoil DMG up + range Increases damage by 1, range by 5.25, and tear height by 0.5.
The Virus 13 The Virus Poison touch Inflicts poison to enemies who make contact with Isaac. Speed down.
Yes, Mother? Mom Transformation.png
  • Isaac gains a stationary knife that trails directly behind him. It synergizes like Mom's Knife would.
Mom's Bottle of Pills 102
Mom's Bottle of Pills
6 rooms
Reusable pill generator Gives Isaac a random pill, and will cause him to drop any held Q-slot item (If any). The player will only receive six different pill types in one playthrough.
Mom's Bra 39
Mom's Bra
3 rooms
Mass Fear Upon use, petrifies all enemies in the current room for approximately 4 seconds.
Mom's Pad 41
Mom's Pad
3 rooms
Gross... Upon use, inflicts fear to all enemies in the room for 5 seconds.
Mom's Wig 217 Mom's Wig You feel itchy... Adds a chance to spawn blue spiders when firing tears. Restores 1 red heart.
Mom's Eye 55 Mom's Eye Eye in the back of your head Allows Isaac to fire tears from the back of his head.
Mom's Purse 139 Mom's Purse More trinket room Allows Isaac to hold 1 additional trinket.
Mom's Contacts 110 Mom's Contacts Freeze effect Adds a chance to shoot petrifying tears, which stop enemies in place and prevent them from moving or attacking. Range up.
Mom's Knife 114 Mom's Knife Stab stab stab Isaac's tears are replaced by a knife that pierces enemies, can travel through obstacles, and can hurt enemies while Isaac is holding it. Holding down the fire button before firing increases its range and power.
Mom's Heels 30 Mom's Heels Range up Increases range.
Mom's Eyeshadow 200 Mom's Eyeshadow Charm tears Tears have a chance to charm enemies.
Mom's Perfume 228 Mom's Perfume Fear shot Adds a chance to shoot fear tears and decreases tear delay by 1.
Mom's Key 199 Mom's Key Less is now more +2 keys Spawns 2 keys. Generates additional pickups from chests.
Mom's Lipstick 31 Mom's Lipstick Range up Increases range and shot height.
Mom's Underwear 29 Mom's Underwear Range up Increases range.
Mom's Coin Purse 195 Mom's Coin Purse What's all this...? Spawns 4 random pills around Isaac.
Afterbirth-exclusive content Mom's Pearls 355 Mom's Pearls Range + luck up +1.25 Range Up. +0.5 Tear Height. +1 Luck Up.
Afterbirth †-exclusive content Mom's Razor 508 Mom's Razor It's sharp! Spawns an orbiting razor that damages enemies it touches and inflicts bleeding on enemies, causing them to slowly take damage over time.
Super Bum Super Bum.png
1
Bum Friend 144 Bum Friend He's greedy A portable beggar who follows Isaac, picks up coins for himself, and occasionally drops a pickup after collecting a coin. Does not spawn collectibles.
Dark Bum 278 Dark Bum He wants to take your life Spawns a familiar that follows Isaac around and collects red hearts. For every one-and-a-half red hearts collected, Dark Bum will generate one soul heart, one hostile Spider or one friendly blue spider.
Afterbirth-exclusive content Key Bum 388 Key Bum He wants your keys! Spawns a portable key master that follows Isaac and collects keys, giving random chests in return.
1: Image depicts the familiar. This transformation does not alter Isaac's appearance.

The Binding of Isaac: Afterbirth†[edit source]

Transformation Appearance Transformation effect Item Icon Item effect Recharge
Bookworm Bookworm Transformation.png
  • Roughly 50% of the time, Isaac shoots an extra tear, like 20/20.
Anarchist Cookbook 65
Anarchist Cookbook
3 rooms
Summon bombs Spawns six troll bombs around the room.
Book of Revelations 78
Book of Revelations
6 rooms
Reusable soul protection Adds 1 soul heart, increases the chance for a Devil or Angel Room to appear, and increases the chance for the next boss to be a Horseman (except on XL floors and floors with fixed bosses such as Mom).
Book of Secrets 287
Book of Secrets
6 rooms
?????? Upon use, gives the effect of Treasure Map, The Compass, or Blue Map for the duration of the current floor.
Book of Shadows 58
Book of Shadows
3 rooms
Temporary Invincibility Upon use, creates a protective shield nullifying all types of damage for 10 seconds.
How to Jump 282
How to Jump
Unlimited
It's about time you learned how Gives Isaac the ability to jump (over gaps, spikes, etc.).
Monster Manual 123
Monster Manual
3 rooms
Temporary buddy generator Summons a random familiar for the current room. Can summon familiars not yet unlocked.
Satanic Bible 292
Satanic Bible
6 rooms
Reusable Evil Upon activation, Isaac gains a black heart.
Telepathy for Dummies 192
Telepathy for Dummies
2 rooms
Temporary psychic shot Upon activation, grants homing tears for the current room.
The Bible 33
The Bible
6 rooms
Temporary Flight Upon activation, Isaac gains flight, allowing him to pass over all obstacles in the current room. Instantly kills Mom, Mom's Heart, and It Lives when activated, but will kill Isaac when activated while fighting Satan.
The Book of Belial 34
The Book of Belial
3 rooms
Temporary DMG up Upon use increases damage by 2 for the current room and by a further +50% if the character also has the Blood of the Martyr.
Removed in Afterbirth Guarantees a Devil Room or Angel Room will be open after beating a boss while holding it.
Added in Afterbirth Increases the chance for a Devil or Angel Room to appear by 12.5%.
The Book of Sin 97
The Book of Sin
4 rooms
Reusable Item Generator Spawns a random pickup, pill, card, or trinket.
The Necronomicon 35
The Necronomicon
6 rooms
Mass room damage Damages all enemies in the room significantly.
Spider Baby Spider Baby Transformation.png
  • Spawns a spider familiar that applies random status effects to enemies it comes in contact with.
Box of Spiders 288
Box of Spiders
2 rooms
It's a box of spiders Summons 2-4 blue spiders.
Mutant Spider 153 Mutant Spider Quad shot Grants quadruple shot but decreases tears.
Spider Baby 211 Spider Baby Spider revenge When hit, spawns up to 2 blue spiders.
Spider Bite 89 Spider Bite Slow effect Adds a chance to shoot slowing tears, reducing speed of enemy movement and any projectile fired by them.
Spider Butt 171
Spider Butt
2 rooms
Mass enemy slowdown + damage Damages all enemies in the room and slows them and their projectiles down.
Afterbirth-exclusive content Spider Mod 403 Spider Mod Mod buddy! Displays Isaac's tear damage and enemy health bars. Spawns a gray spider familiar that wanders around and inflicts a random status effect on any enemies it comes into contact with. Occasionally spawns a blue spider upon clearing a room.
Adult Adult Transformation.png
  • Grants a heart container.
3 Puberty pills
Stompy None
  • Taking damage has a chance to spawn rock waves.
Leo 302 Leo Stompy Allows you to crush rocks when you walk over them.
Magic Mushroom 12 Magic Mushroom All Stats Up! Increases all stats and enlargens Isaac.
One Makes You Larger pills

Notes[edit | edit source]

  • Activated items (e.g. Guppy's Head Guppy's Head) only need to be touched in order to count. Keeping them, or even activating them once, is not required.
  • Rerolling items with a dice room, the D4 D4, or the D100 D100 will not remove progress towards the transformation.
  • Transformations can be combined with each other, keeping the effects of any and all transformations with no effects overriding others.
  • Transforming into Beelzebub for the first time will unlock the Lord of the Flies achievement.
  • Since none of the Afterbirth transformations unlock an achievement or item, attaining them is not required for 100% completion of the game in terms of achievements.
  • Many of the Afterbirth transformations override the charge animations of items such as Monstro's Lung Monstro's Lung and Brimstone Brimstone, potentially making them more difficult to use.
    • Added in Afterbirth † There is now an option to show a charge bar that floats above Isaac.
  • Added in Afterbirth Familiars gained from Cambion Conception Cambion Conception or Immaculate Conception Immaculate Conception do not count towards transformation progress.

Trivia[edit | edit source]

  • There are two transformations in the base game, nine more in the Afterbirth DLC, and four more in the Afterbirth † DLC.
  • In the original The Binding of Isaac flash game, the transformation into Guppy was the only one available, making it chronologically the first.
    • The Eternal Edition of the original The Binding of Isaac game added another transformation that turned Isaac into an angel after gaining 7 heart containers from eternal hearts.
  • Rebirth introduced Beelzebub as the chronologically second transformation.
  • The original name for the Beelzebub transformation was Lord of the Flies.


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