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Guppy Beelzebub DLC Indicator.png  Super Bum DLC Indicator.png  Yes Mother DLC Indicator.png  Bob DLC Indicator.png  Fun Guy DLC Indicator.png  Leviathan DLC Indicator.png  Conjoined
DLC Indicator.png  Spun DLC Indicator.png  Seraphim DLC Indicator.png  Oh Crap Afterbirth† Indicator.png  Bookworm Afterbirth† Indicator.png  Spider Baby Afterbirth† Indicator.png  Adult Afterbirth† Indicator.png  Stompy

Transformations alter Isaac's appearance and grant him special abilities.

A transformation occurs when obtaining at least three collectibles from a particular set of items.
These collectibles always share a particular theme that corresponds with the transformation.

Transformation sets[edit | edit source]

The Binding of Isaac: Rebirth[edit source]

Transformation Appearance Transformation effect Item Icon Item effect Recharge
Beelzebub Beelzebub App.png
???'s Only Friend Blue Baby's Only Friend Icon.png Summons a big attack fly that can be controlled with the shooting direction-keys.
Angry Fly Afterbirth† Indicator.png Angry Fly Icon.png Spawns a fly familiar that orbits around a random enemy and deals 2 damage per tick to enemies it comes in contact with.
BBF BBF Icon.png Spawns a familiar that flies around the room in a manner similar to the Boom Fly and explodes on contact with an enemy. Respawns after ten seconds.
Best Bud Best Bud Icon.png When hit, summons a white attack fly similar to Distant Admiration for the current room.
Big Fan Big Fan Icon.png Spawns a large orbital familiar that blocks enemy projectiles and deals slight contact damage to enemies.
Distant Admiration Distant Admiration Icon.png A red attack fly circles further out than the Halo of Flies / Pretty Flies, but closer than Forever Alone. Deals more damage than Forever Alone.
Forever Alone Forever Alone Icon.png Spawns a blue attack fly that orbits a long distance from Isaac.
Halo of Flies Halo of Flies Icon.png Spawns two pretty fly familiars that block enemy shots and deal contact damage to enemies.
Hive Mind Hive Mind Icon.png Increases the size of blue spiders and Blue Flies and doubles the amount of damage they deal.
Skatole Skatole Icon.png All types of fly except Boom Fly and Red Boom Fly become passive and slowly move towards Isaac. Does not prevent contact damage.
Smart Fly Smart Fly Icon.png After Isaac takes damage, this fly will deal continuous touch damage to whatever enemy caused the damage until it is dead. The fly will then systematically attack 1 enemy at a time until the room is cleared.
The Mulligan The Mulligan Icon.png Tears have a 1/6 chance of spawning allied blue flies when they hit an enemy.
Infestation Infestation Icon.png 1-3 Blue flies randomly spawn every time Isaac gets hit.
Friend Zone DLC Indicator.png Friend Zone Icon.png A white orbiting fly which deals 3 contact damage per tick to enemies. This familiar orbits Isaac at a middle length distance somewhere between Distant Admiration and Forever Alone.
Lost Fly DLC Indicator.png Lost Fly Icon.png A familiar fly that moves in a straight line and attaches itself to the first obstacle or wall it comes into contact with in each room. If any enemies walk into its path, it will deal 7 contact damage per tick. If the obstacle it is attached to is destroyed then it will continue rolling in the direction it was previously travelling until it meets another wall or obstacle.
Papa Fly DLC Indicator.png Papa Fly Icon.png A blue fly familiar follows Isaac's movements on a 3 second delay. Papa Fly will fire tears at nearby enemies.
Obsessed Fan DLC Indicator.png Obsessed Fan Icon.png A purple fly familiar that follows Isaac's movements on a 3 second delay and deals contact damage to enemies.
Guppy! Guppy App.png
Guppy's Head Guppy's Head Icon.png Spawns 2-4 blue flies to damage enemies. 1
Guppy's Paw Guppy's Paw Icon.png Removes one red heart container in exchange for gaining 3 Soul Hearts. 0
Dead Cat Dead Cat Icon.png Sets the amount of red heart containers to 1, but gives Isaac 9 extra lives. After dying, Isaac is teleported to the last safe room. New heart containers can be obtained after picking up this item, but after each death, the number of heart containers is set to 1 again.
Guppy's Collar Guppy's Collar Icon.png Grants Isaac a permanent 50% chance to respawn with 1/2 of a red heart after death.
Guppy's Tail Guppy's Tail Icon.png Increases chance of finding gold chests and normal chests, but reduces chance of finding pickups.
Guppy's Hair Ball Guppy's Hair Ball Icon.png Loosely follows behind Isaac. Can be swung like a flail by rapidly spinning Isaac in a circle. Grows bigger by killing enemies.

The Binding of Isaac: Afterbirth[edit source]

Transformation Appearance Transformation effect Item Icon Item effect Recharge
Bob Bob Transformation.png
Bob's Rotten Head Bob's Rotten Head Icon.png Upon use, Isaac holds a poison bomb which can be thrown towards any of the four cardinal points and explodes on impact. 3
Bob's Brain Bob's Brain Icon.png Spawns a familiar that charges forward when shooting tears, explodes upon contact with an enemy and poisons them. Respawns after few seconds.
Bob's Curse Bob's Curse Icon.png Gives 5 bombs and grants all bombs poison effect.
Ipecac Ipecac Icon.png Replaces tears with explosive and poisoning projectiles fired in an arc from the mouth.
Conjoined Baby Transformation.png
  • When attacking, the tumor faces shoot tears diagonally outwards, similar to the effect of The Wiz.
  • -0.3 damage.
  • Slightly decreases tears.
Brother Bobby Brother Bobby Icon.png Follows Isaac around shooting normal tears.
Harlequin Baby Harlequin Baby Icon.png Spawns a familiar that follows Isaac around and fires two tears at once in a V-pattern.
Headless Baby Headless Baby Icon.png Familiar that follows Isaac, leaving blood creep on the ground.
Little Steven Little Steven Icon.png Spawns a familiar that follows Isaac around and fires homing tears.
Mongo Baby Mongo Baby Icon.png Summons a familiar that copies the tears of Isaac's other familiars.
Rotten Baby Rotten Baby Icon.png A familiar that spawns blue flies.
Sister Maggy Sister Maggy Icon.png A familiar that follows Isaac around shooting blood tears.
Fun Guy Mushroom Transformation.png
God's Flesh DLC Indicator.png God's Flesh Icon.png Tears now have a random chance to apply a shrinking effect, causing enemies to shrink in size and also run away from Isaac. Shrunk enemies can be crushed and killed by walking over them.
Mini Mush Mini Mush Icon.png Increases Speed and Shot Height and decreases Isaac's size, but lowers Range.
Magic Mushroom Magic Mushroom Icon.png Increases all stats and enlargens Isaac.
Odd Mushroom Odd Mushroom (Thin) Icon.png Increases Tears and Speed while reducing Damage.
Odd Mushroom Odd Mushroom (Large) Icon.png Grants an empty heart container. Increases damage, range and shot height while reducing speed.
1up! 1up! Icon.png Gives an extra life. Upon death, you will respawn in the previous room with full health and lose the 1up!.
Blue Cap Blue Cap Icon.png Grants 1 heart container and increases tears, but decreases shot speed.
Leviathan Evil Angel Transformation.png
The Nail The Nail Icon.png Adds one soul heart and allows the breaking of rocks and damaging enemies by simply walking over them. Increases damage and decreases speed. All effects except for the Soul Heart wear off upon leaving the room. 6
The Mark The Mark Icon.png Increases Damage and Speed, plus adds one Soul Heart.
Missing Page 2 Missing Page 2 Icon.png Gives 1 black heart. Upon taking damage that reduces Isaac's health to one heart or less, activates The Necronomicon effect, dealing 40 damage to all enemies in the room.
The Pact The Pact Icon.png Increases damage by 0.5, tears by 0.7 and grants two soul hearts upon pickup.
Pentagram Pentagram Icon.png Increases damage and increases the chance for a Devil or Angel Room to appear.
Spirit of the Night Spirit of the Night Icon.png Grants spectral tears and flight.
Maw of the Void DLC Indicator.png Maw of the Void Icon.png +1.0 Damage Up. After continuously firing tears for 2.5 seconds, a red cross appears on Isaac's head that, upon releasing the fire button, creates a black ring that rapidly deals damage equal to Isaac's tear damage to any enemies in contact with it.
Abaddon Abaddon Icon.png Increases damage and speed, removes all red heart containers, grants six black hearts, and adds a chance to shoot fear tears.
Brimstone Brimstone Icon.png Tears are replaced by a laser beam that pierces through all enemies and obstacles in its path and deals high damage. Can only be fired after a short charge-up period.
Oh Crap Poop Transformation.png
  • Whenever a pile of poop is destroyed, health is replenished by half a heart.
Flush! Flush! Icon.png Changes all enemies in the room into poop. Does not work on all enemies (Knights and bosses are immune). Instantly kills Dingle, Dangle, and Brownie. 6
The Poop The Poop Icon.png Spawns a pile of poop where the character is standing and knocks nearby monsters back. May yield pickups like regular poop. 1
E Coli E Coli Icon.png Gives "Turdy Touch" Effect. Enemies that touch Isaac are changed into poop.
Seraphim Angel Transformation.png
The Bible The Bible Icon.png Upon activation, Isaac gains flight, allowing him to pass over all obstacles in the current room. Instantly kills Mom, Mom's Heart, and It Lives when activated, but will kill Isaac when activated while fighting Satan. 6
Dead Dove Dead Dove Icon.png Grants spectral tears and flight.
Guardian Angel Guardian Angel Icon.png Spawns an orbital familiar that blocks enemy projectiles, deals contact damage to enemies, and increases the speed of all orbital familiars.
Holy Grail Holy Grail Icon.png Grants flight and one heart container.
Holy Mantle Holy Mantle Icon.png Automatically negates first taken damage in every room.
Mitre Mitre Icon.png Grants a chance of converting any red hearts pickups into soul hearts instead.
Rosary Rosary Icon.png Adds 3 Soul Hearts and increases the chance for The Bible to appear in any item pool.
Sworn Protector DLC Indicator.png Sworn Protector Icon.png An orbital angel which does 7 contact damage per tick and blocks enemy shots. When it blocks a shot, it has a very small chance to drop an eternal heart.
The Halo The Halo Icon.png Grants one Heart Container, +0.3 Damage, +0.2 Tears, +0.25 Range, +0.3 Speed, and +0.5 Tear Height.
Spun Drugs Transformation.png
Adrenaline Afterbirth† Indicator.png Adrenaline Icon.png Increases damage based on how many empty heart containers Isaac has.
Euthanasia Afterbirth† Indicator.png Euthanasia Icon.png Adds a chance to fire needles. If a needle kills an enemy, it bursts into more needles.
Experimental Treatment Experimental Treatment Icon.png Randomly increases and decreases some of the character's stats. There will always be at least one stat increase and one decrease and the same stats can be increased/decreased multiple times.
Growth Hormones Growth Hormones Icon.png Increases damage by 1 and speed by 0.4.
Roid Rage Roid Rage Icon.png Increases speed by 0.6, range by 5.25, and tear height by 0.5.
Speed Ball Speed Ball Icon.png Increases speed by 0.3 and shot speed by 20%.
Synthoil Synthoil Icon.png Increases damage by 1, range by 5.25, and tear height by 0.5.
The Virus The Virus Icon.png Inflicts poison to enemies who make contact with Isaac. Speed down.
Yes, Mother? Mom Transformation.png
  • Isaac gains a stationary knife that trails directly behind him. It synergizes like Mom's Knife would.
Mom's Bottle of Pills Mom's Bottle of Pills Icon.png Gives Isaac a random pill, and will cause him to drop any held Q-slot item (If any). The player will only receive six different pill types in one playthrough. 6
Mom's Bra Mom's Bra Icon.png Upon use, petrifies all enemies in the current room for approximately 4 seconds. 3
Mom's Pad Mom's Pad Icon.png Upon use, inflicts fear to all enemies in the room for 5 seconds. 3
Mom's Wig Mom's Wig Icon.png Adds a chance to spawn blue spiders when firing tears. Restores 1 red heart.
Mom's Eye Mom's Eye Icon.png Allows Isaac to fire tears from the back of his head.
Mom's Purse Mom's Purse Icon.png Allows Isaac to hold 1 additional trinket.
Mom's Contacts Mom's Contacts Icon.png Adds a chance to shoot petrifying tears, which stop enemies in place and prevent them from moving or attacking. Range up.
Mom's Knife Mom's Knife Icon.png Isaac's tears are replaced by a knife that pierces enemies, can travel through obstacles, and can hurt enemies while Isaac is holding it. Holding down the fire button before firing increases its range and power.
Mom's Heels Mom's Heels Icon.png Increases range.
Mom's Eyeshadow Mom's Eyeshadow Icon.png Tears have a chance to charm enemies.
Mom's Perfume Mom's Perfume Icon.png Adds a chance to shoot fear tears and decreases tear delay by 1.
Mom's Key Mom's Key Icon.png Spawns 2 keys. Generates additional pickups from chests.
Mom's Lipstick Mom's Lipstick Icon.png Increases range and shot height.
Mom's Underwear Mom's Underwear Icon.png Increases range.
Mom's Coin Purse Mom's Coin Purse Icon.png Spawns 4 random pills around Isaac.
Mom's Pearls DLC Indicator.png Mom's Pearls Icon.png +1.25 Range Up. +0.5 Tear Height. +1 Luck Up.
Mom's Razor Afterbirth† Indicator.png Mom's Razor Icon.png Spawns an orbiting razor that damages enemies it touches and inflicts bleeding on enemies, causing them to slowly take damage over time.
Super Bum Super Bum.png
Bum Friend Bum Friend Icon.png A portable beggar who follows Isaac, picks up coins for himself, and occasionally drops a pickup after collecting a coin. Does not spawn collectibles.
Dark Bum Dark Bum Icon.png Spawns a familiar that follows Isaac around and collects red hearts. For every one-and-a-half red hearts collected, Dark Bum will generate one soul heart, one hostile Spider or one friendly blue spider.
Key Bum DLC Indicator.png Key Bum Icon.png Spawns a portable key master that follows Isaac and collects keys, giving random chests in return.
1: Image depicts the familiar. This transformation does not alter Isaac's appearance.

The Binding of Isaac: Afterbirth†[edit source]

Transformation Appearance Transformation effect Item Icon Item effect Recharge
Bookworm Bookworm Transformation.png
  • Roughly 50% of the time, Isaac shoots an extra tear, like 20/20.
Anarchist Cookbook Anarchist Cookbook Icon.png Spawns six troll bombs around the room. 3
Book of Revelations Book of Revelations Icon.png Adds 1 soul heart, increases the chance for a Devil or Angel Room to appear, and increases the chance for the next boss to be a Horseman (except on XL floors and floors with fixed bosses such as Mom). 6
Book of Secrets Book of Secrets Icon.png Upon use, gives the effect of Treasure Map, The Compass, or Blue Map for the duration of the current floor. 6
Book of Shadows Book of Shadows Icon.png Upon use, creates a protective shield nullifying all types of damage for 10 seconds. 3
How to Jump How to Jump Icon.png Gives Isaac the ability to jump (over gaps, spikes, etc.). 0
Monster Manual Monster Manual Icon.png Summons a random familiar for the current room. Can summon familiars not yet unlocked. 3
Satanic Bible Satanic Bible Icon.png Upon activation, Isaac gains a black heart. 6
Telepathy for Dummies Telepathy for Dummies Icon.png Upon activation, grants homing tears for the current room. 2
The Bible The Bible Icon.png Upon activation, Isaac gains flight, allowing him to pass over all obstacles in the current room. Instantly kills Mom, Mom's Heart, and It Lives when activated, but will kill Isaac when activated while fighting Satan. 6
The Book of Belial The Book of Belial Icon.png Upon use increases damage by 2 for the current room and by a further +50% if the character also has the Blood of the Martyr.
NoDLC Indicator.png Guarantees a Devil Room or Angel Room will be open after beating a boss while holding it.
DLC Indicator.png Increases the chance for a Devil or Angel Room to appear by 12.5%.
The Book of Sin The Book of Sin Icon.png Spawns a random pickup, pill, card, or trinket. 4
The Necronomicon The Necronomicon Icon.png Damages all enemies in the room significantly. 6
Spider Baby Spider Baby Transformation.png
  • Spawns a spider familiar that applies random status effects to enemies it comes in contact with.
Box of Spiders Box of Spiders Icon.png Summons 2-4 blue spiders. 2
Mutant Spider Mutant Spider Icon.png Grants quadruple shot but decreases tears.
Spider Baby Spider Baby Icon.png When hit, spawns up to 2 blue spiders.
Spider Bite Spider Bite Icon.png Adds a chance to shoot slowing tears, reducing speed of enemy movement and any projectile fired by them.
Spider Butt Spider Butt Icon.png Damages all enemies in the room and slows them and their projectiles down. 2
Spider Mod DLC Indicator.png Spider Mod Icon.png Displays Isaac's tear damage and enemy health bars. Spawns a gray spider familiar that wanders around and inflicts a random status effect on any enemies it comes into contact with. Occasionally spawns a blue spider upon clearing a room.
Adult Adult Transformation.png
  • Grants a heart container.
3 Puberty pills
Stompy None
  • Taking damage has a chance to spawn rock waves.
Leo Leo Icon.png Allows you to crush rocks when you walk over them.
Magic Mushroom Magic Mushroom Icon.png Increases all stats and enlargens Isaac.
One Makes You Larger pills

Notes[edit | edit source]

  • Activated items (e.g. Guppy's Head Guppy's Head ) only need to be touched in order to count. Keeping them, or even activating them once, is not required.
  • Rerolling items with a dice room, the D4 D4 , or the D100 D100 will not remove progress towards the transformation.
  • Transformations can be combined with each other, keeping the effects of any and all transformations with no effects overriding others.
  • Transforming into Beelzebub for the first time will unlock the Lord of the Flies achievement.
  • Since none of the Afterbirth transformations unlock an achievement or item, attaining them is not required for 100% completion of the game in terms of achievements.
  • Many of the Afterbirth transformations override the charge animations of items such as Monstro's Lung Monstro's Lung and Brimstone Brimstone , potentially making them more difficult to use.
    • Afterbirth† Indicator.png There is now an option to show a charge bar that floats above Isaac.
  • DLC Indicator.png Familiars gained from Cambion Conception Cambion Conception or Immaculate Conception Immaculate Conception do not count towards transformation progress.

Trivia[edit | edit source]

  • There are two transformations in the base game, nine more in the Afterbirth DLC, and four more in the Afterbirth † DLC.
  • In the original The Binding of Isaac flash game, the transformation into Guppy was the only one available, making it chronologically the first.
    • The Eternal Edition of the original The Binding of Isaac game added another transformation that turned Isaac into an angel after gaining 7 heart containers from eternal hearts.
  • Rebirth introduced Beelzebub as the chronologically second transformation.
  • The original name for the Beelzebub transformation was Lord of the Flies.

SmallIsaac.png The Binding of Isaac: Rebirth SmallIsaac.png

MainPageAchievements.png Achievements MainPageAttributes.png Attributes MainPageBosses.png Bosses TarotCard.png Cards and Runes MainPageChallenges.png Challenges MainPageChapters.png Chapters
Isaac App.png Characters MainPageBabies.png Co-op Magic Mushroom Icon.png Items Isaac's Tears Icon.png Item Pools MainPageMonsters.png Monsters MainPageObjects.png Objects
Red heart.png Pickups BlueBlue.png Pills MainPageRooms.png Rooms MainPageSeeds2.png Seeds Guppy App.png Transformations The Left Hand Icon.png Trinkets