| Name
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Appearance
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Description
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Items
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| Bob
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 Bob's Rotten Head  Upon use, Isaac holds a poison bomb which can be thrown towards any of the four cardinal points and explodes on impact.
 Bob's Brain Spawns a familiar that charges forward when shooting tears and explodes upon contact with an enemy, damaging and poisoning them. The familiar respawns after a few seconds.
 Bob's Curse Gives 5 bombs and grants all bombs poison effect.
 Ipecac Replaces tears with explosive and poisoning projectiles fired in an arc from the mouth.
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| Conjoined
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- When attacking, the tumor faces shoot tears diagonally outwards, similar to the effect of The Wiz.
- -0.3 damage.
- Slightly decreases tears.
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 Brother Bobby Follows Isaac around shooting normal tears.
 Harlequin Baby Spawns a familiar that follows Isaac around and fires two tears at once in a V-pattern.
 Headless Baby Familiar that follows Isaac, leaving blood creep on the ground.
 Little Steven Spawns a familiar that follows Isaac around and fires homing tears.
 Mongo Baby Summons a familiar that copies the tears of Isaac's other familiars.
 Rotten Baby A familiar that spawns blue flies.
 Sister Maggy A familiar that follows Isaac around shooting blood tears.
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| Fun Guy
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 1up! Gives an extra life. Upon death, you will respawn in the previous room with full health and lose the 1up!.
 Blue Cap Grants 1 heart container and increases tears, but decreases shot speed.
 God's Flesh Tears now have a random chance to apply a shrinking effect, causing enemies to shrink in size and also run away from Isaac. Shrunk enemies can be crushed and killed by walking over them.
 Magic Mushroom Increases all stats and enlargens Isaac.
 Mini Mush Increases Speed and Shot Height and decreases Isaac's size, but lowers Range.
 Odd Mushroom Grants an empty heart container. Increases damage, range and shot height while reducing speed.
 Odd Mushroom +1.7 tears, +0.3 speed, reduces damage.
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| Leviathan
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 The Nail  Adds one soul heart and allows the breaking of rocks and damaging enemies by simply walking over them. Increases damage and decreases speed. All effects except for the Soul Heart wear off upon leaving the room.
 Abaddon Increases damage and speed, removes all red heart containers, grants six black hearts, and adds a chance to shoot fear tears.
 Brimstone Tears are replaced by a laser beam that pierces through all enemies and obstacles in its path and deals high damage. Can only be fired after a short charge-up period.
 The Mark Increases Damage and Speed, plus adds one Soul Heart.
 Maw of the Void +1.0 Damage Up. After continuously firing tears for 2.5 seconds, a red cross appears on Isaac's head that, upon releasing the fire button, creates a black ring that rapidly deals damage equal to Isaac's tear damage to any enemies in contact with it.
 The Pact Increases damage by 0.5, tears by 0.7 and grants two soul hearts upon pickup.
 Pentagram Increases damage and increases the chance for a Devil or Angel Room to appear.
 Spirit of the Night Grants spectral tears and flight.
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| Oh Crap
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- Whenever a pile of poop is destroyed, health is replenished by half a heart.
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 Flush! Changes all enemies in the room into poop. Does not work on all enemies (Knights and bosses are immune). Instantly kills Dingle, Dangle, and Brownie.
 The Poop  Spawns a pile of poop where the character is standing and knocks nearby monsters back. May yield pickups like regular poop.
 E Coli Gives "Turdy Touch" Effect. Enemies that touch Isaac are changed into poop.
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| Seraphim
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 The Bible Upon activation, Isaac gains flight, allowing him to pass over all obstacles in the current room. Instantly kills Mom, Mom's Heart, and It Lives when activated, but will kill Isaac when activated while fighting Satan.
 Dead Dove Grants spectral tears and flight.
 Guardian Angel Spawns an orbital familiar that blocks enemy projectiles, deals contact damage to enemies, and increases the speed of all orbital familiars.
 The Halo Grants one Heart Container, +0.3 Damage, +0.2 Tears, +0.25 Range, +0.3 Speed, and +0.5 Tear Height.
 Holy Grail Grants flight and one heart container.
 Holy Mantle Automatically negates first taken damage in every room.
 Mitre Grants a chance of converting any red hearts pickups into soul hearts instead.
 Rosary Adds 3 Soul Hearts and increases the chance for The Bible to appear in any item pool.
 Sworn Protector An orbital angel which does 7 contact damage per tick and blocks enemy shots. Upon blocking 10 shots in a room it drops an eternal heart.
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| Spun
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  Adrenaline Increases damage based on how many empty heart containers Isaac has.
 Euthanasia Adds a chance to fire needles. If a needle kills an enemy, it bursts into more needles.
 Experimental Treatment Randomly increases and decreases some of the character's stats. There will always be at least one stat increase and one decrease and the same stats can be increased/decreased multiple times.
 Growth Hormones Increases damage by 1 and speed by 0.4.
 Roid Rage Increases speed by 0.6, range by 5.25, and tear height by 0.5.
 Speed Ball Increases speed by 0.3 and shot speed by 20%.
 Synthoil Increases damage by 1, range by 5.25, and tear height by 0.5.
 The Virus Inflicts poison to enemies who make contact with Isaac. Speed down.
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| Yes Mother?
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- Isaac gains a stationary knife that trails directly behind him. It synergizes like Mom's Knife would.
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 Mom's Bottle of Pills Gives Isaac a random pill, and will cause him to drop any held Q-slot item (If any). The player will only receive six different pill types in one playthrough.
 Mom's Bra Upon use, petrifies all enemies in the current room for approximately 4 seconds.
 Mom's Pad Upon use, inflicts fear to all enemies in the room for 5 seconds.
 Mom's Shovel  Spawns a trapdoor that leads to the next floor upon activation. Unlocks The Forgotten when used on a mound of dirt that appears in The Dark Room.
 Mom's Coin Purse Spawns 4 random pills around Isaac.
 Mom's Contacts Adds a chance to shoot petrifying tears, which stop enemies in place and prevent them from moving or attacking. Range up.
 Mom's Eye Allows Isaac to fire tears from the back of his head.
 Mom's Eyeshadow Tears have a chance to charm enemies.
 Mom's Heels Increases range.
 Mom's Key Spawns 2 keys. Generates additional pickups from chests.
 Mom's Knife Isaac's tears are replaced by a knife that pierces enemies, can travel through obstacles, and can hurt enemies while Isaac is holding it. Holding down the fire button before firing increases its range and power.
 Mom's Lipstick Increases range and shot height.
 Mom's Pearls +1.25 Range Up. +0.5 Tear Height. +1 Luck Up.
 Mom's Perfume Adds a chance to shoot fear tears and decreases tear delay by 1.
 Mom's Purse Allows Isaac to hold 1 additional trinket.
 Mom's Razor Spawns an orbiting razor that damages enemies it touches and inflicts bleeding on enemies, causing them to slowly take damage over time.
 Mom's Underwear Increases range.
 Mom's Wig Adds a chance to spawn blue spiders when firing tears. Restores 1 red heart.
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| Super Bum
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 Bum Friend A portable beggar who follows Isaac, picks up coins for himself, and occasionally drops a pickup after collecting a coin. Does not spawn collectibles.
 Dark Bum Spawns a familiar that follows Isaac around and collects red hearts. For every one-and-a-half red hearts collected, Dark Bum will generate one soul heart, one hostile Spider or one friendly blue spider.
 Key Bum Spawns a portable key master that follows Isaac and collects keys, giving random chests in return.
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Super Bum
Spawns a familiar that charges forward when shooting tears and explodes upon contact with an enemy, damaging and poisoning them. The familiar respawns after a few seconds.
Gives 5 bombs and grants all bombs poison effect.
Replaces tears with explosive and poisoning projectiles fired in an arc from the mouth.
Follows Isaac around shooting normal tears.
Spawns a familiar that follows Isaac around and fires two tears at once in a V-pattern.
Familiar that follows Isaac, leaving blood creep on the ground.
Spawns a familiar that follows Isaac around and fires homing tears.
Summons a familiar that copies the tears of Isaac's other familiars.
A familiar that spawns blue flies.
A familiar that follows Isaac around shooting blood tears.
Gives an extra life. Upon death, you will respawn in the previous room with full health and lose the 1up!.
Grants 1 heart container and increases tears, but decreases shot speed.
Tears now have a random chance to apply a shrinking effect, causing enemies to shrink in size and also run away from Isaac. Shrunk enemies can be crushed and killed by walking over them.
Increases all stats and enlargens Isaac.
Increases Speed and Shot Height and decreases Isaac's size, but lowers Range._Icon.png){kind=icon}
Grants an empty heart container. Increases damage, range and shot height while reducing speed._Icon.png){kind=icon}
+1.7 tears, +0.3 speed, reduces damage.
Increases damage and speed, removes all red heart containers, grants six black hearts, and adds a chance to shoot fear tears.
Tears are replaced by a laser beam that pierces through all enemies and obstacles in its path and deals high damage. Can only be fired after a short charge-up period.
Increases Damage and Speed, plus adds one Soul Heart.
+1.0 Damage Up. After continuously firing tears for 2.5 seconds, a red cross appears on Isaac's head that, upon releasing the fire button, creates a black ring that rapidly deals damage equal to Isaac's tear damage to any enemies in contact with it.
Increases damage by 0.5, tears by 0.7 and grants two soul hearts upon pickup.
Increases damage and increases the chance for a Devil or Angel Room to appear.
Grants spectral tears and flight.
Gives "Turdy Touch" Effect. Enemies that touch Isaac are changed into poop.
Grants spectral tears and flight.
Spawns an orbital familiar that blocks enemy projectiles, deals contact damage to enemies, and increases the speed of all orbital familiars.
Grants one Heart Container, +0.3 Damage, +0.2 Tears, +0.25 Range, +0.3 Speed, and +0.5 Tear Height.
Grants flight and one heart container.
Automatically negates first taken damage in every room.
Grants a chance of converting any red hearts pickups into soul hearts instead.
Adds 3 Soul Hearts and increases the chance for The Bible to appear in any item pool.
An orbital angel which does 7 contact damage per tick and blocks enemy shots. Upon blocking 10 shots in a room it drops an eternal heart.
Increases damage based on how many empty heart containers Isaac has.
Adds a chance to fire needles. If a needle kills an enemy, it bursts into more needles.
Randomly increases and decreases some of the character's stats. There will always be at least one stat increase and one decrease and the same stats can be increased/decreased multiple times.
Increases damage by 1 and speed by 0.4.
Increases speed by 0.6, range by 5.25, and tear height by 0.5.
Increases speed by 0.3 and shot speed by 20%.
Increases damage by 1, range by 5.25, and tear height by 0.5.
Inflicts poison to enemies who make contact with Isaac. Speed down.
Spawns 4 random pills around Isaac.
Adds a chance to shoot petrifying tears, which stop enemies in place and prevent them from moving or attacking. Range up.
Allows Isaac to fire tears from the back of his head.
Tears have a chance to charm enemies.
Increases range.
Spawns 2 keys. Generates additional pickups from chests.
Isaac's tears are replaced by a knife that pierces enemies, can travel through obstacles, and can hurt enemies while Isaac is holding it. Holding down the fire button before firing increases its range and power.
Increases range and shot height.
+1.25 Range Up. +0.5 Tear Height. +1 Luck Up.
Adds a chance to shoot fear tears and decreases tear delay by 1.
Allows Isaac to hold 1 additional trinket.
Spawns an orbiting razor that damages enemies it touches and inflicts bleeding on enemies, causing them to slowly take damage over time.
Increases range.
Adds a chance to spawn blue spiders when firing tears. Restores 1 red heart.
A portable beggar who follows Isaac, picks up coins for himself, and occasionally drops a pickup after collecting a coin. Does not spawn collectibles.
Spawns a familiar that follows Isaac around and collects red hearts. For every one-and-a-half red hearts collected, Dark Bum will generate one soul heart, one hostile Spider or one friendly blue spider.
Spawns a portable key master that follows Isaac and collects keys, giving random chests in return.
Anarchist Cookbook
The Book of Belial
Guarantees a Devil Room or Angel Room will be open after beating a boss while holding it, or 
Book of Revelations
Book of Secrets
Book of Shadows
The Book of Sin
Book of the Dead
How to Jump
Gives Isaac the ability to jump (over gaps, spikes, etc.).
The Necronomicon
Monster Manual
Satanic Bible
Telepathy for Dummies
Upon activation, grants homing tears for the current room.
Box of Spiders
Spider Butt
Mutant Spider
Grants quadruple shot but decreases tears.
Spider Baby
When hit, spawns up to 2 blue spiders.
Spider Bite
Adds a chance to shoot slowing tears, reducing speed of enemy movement and any projectile fired by them.
Spider Mod
Displays Isaac's tear damage and enemy health bars. Spawns a gray spider familiar that wanders around and inflicts a random status effect on any enemies it comes into contact with. Occasionally spawns a blue spider upon clearing a room.
Leo
Allows you to crush rocks when you walk over them.
Guppy's Head
D4
D100
Monstro's Lung
Increases damage and grants a charged shot that fires multiple tears in the same fashion as Monstro. and 
Cambion Conception
After taking damage a certain amount of times, a permanent demonic familiar spawns. or 
Immaculate Conception
Upon picking up a certain amount of health, spawn a permanent angelic familiar. do not count towards transformation progress.
The Binding of Isaac: Rebirth 
Achievements
Attributes
Bosses
Cards and Runes
Challenges
Chapters
Characters
Co-op
Items
Item Pools
Monsters
Objects
Pickups
Pills
Rooms
Seeds
Transformations
Trinkets
