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Guppy Beelzebub Added in Afterbirth  Super Bum Added in Afterbirth  Yes Mother? Added in Afterbirth  Bob Added in Afterbirth  Fun Guy Added in Afterbirth  Leviathan Added in Afterbirth  Conjoined
Added in Afterbirth  Spun Added in Afterbirth  Seraphim Added in Afterbirth  Oh Crap Added in Afterbirth †  Bookworm Added in Afterbirth †  Spider Baby Added in Afterbirth †  Adult Added in Afterbirth †  Stompy

Transformations alter Isaac's appearance and grant him special abilities.

A transformation occurs when obtaining at least three collectibles from a particular set of items.
These collectibles always share a particular theme that corresponds with the transformation.

Transformation sets[edit | edit source]

The Binding of Isaac: Rebirth[edit | edit source]

Name Appearance Description Items
Beelzebub Beelzebub

Guppy Guppy

The Binding of Isaac: Afterbirth[edit | edit source]

Name Appearance Description Items
Bob Bob Bob's Rotten Head Bob's Rotten HeadBob's Rotten Head Icon.png3 roomsUpon use, Isaac holds a poison bomb which can be thrown towards any of the four cardinal points and explodes on impact.
Bob's Brain Bob's BrainBob's Brain Icon.pngSpawns a familiar that charges forward when shooting tears and explodes upon contact with an enemy, damaging and poisoning them. The familiar respawns after a few seconds.
Bob's Curse Bob's CurseBob's Curse Icon.pngGives 5 bombs and grants all bombs poison effect.
Ipecac IpecacIpecac Icon.pngReplaces tears with explosive and poisoning projectiles fired in an arc from the mouth.
Conjoined Conjoined
  • When attacking, the tumor faces shoot tears diagonally outwards, similar to the effect of The Wiz.
  • -0.3 damage.
  • Slightly decreases tears.
Brother Bobby Brother BobbyBrother Bobby Icon.pngFollows Isaac around shooting normal tears.
Harlequin Baby Harlequin BabyHarlequin Baby Icon.pngSpawns a familiar that follows Isaac around and fires two tears at once in a V-pattern.
Headless Baby Headless BabyHeadless Baby Icon.pngFamiliar that follows Isaac, leaving blood creep on the ground.
Little Steven Little StevenLittle Steven Icon.pngSpawns a familiar that follows Isaac around and fires homing tears.
Mongo Baby Mongo BabyMongo Baby Icon.pngSummons a familiar that copies the tears of Isaac's other familiars.
Rotten Baby Rotten BabyRotten Baby Icon.pngA familiar that spawns blue flies.
Sister Maggy Sister MaggySister Maggy Icon.pngA familiar that follows Isaac around shooting blood tears.
Fun Guy Fun Guy 1up! 1up!1up! Icon.pngGives an extra life. Upon death, you will respawn in the previous room with full health and lose the 1up!.
Blue Cap Blue CapBlue Cap Icon.pngGrants 1 heart container and increases tears, but decreases shot speed.
God's Flesh God's FleshGod's Flesh Icon.pngTears now have a random chance to apply a shrinking effect, causing enemies to shrink in size and also run away from Isaac. Shrunk enemies can be crushed and killed by walking over them.
Magic Mushroom Magic MushroomMagic Mushroom Icon.pngIncreases all stats and enlargens Isaac.
Mini Mush Mini MushMini Mush Icon.pngIncreases Speed and Shot Height and decreases Isaac's size, but lowers Range.
Odd Mushroom Odd MushroomOdd Mushroom (Large) Icon.pngGrants an empty heart container. Increases damage, range and shot height while reducing speed.
Odd Mushroom Odd MushroomOdd Mushroom (Thin) Icon.png+1.7 tears, +0.3 speed, reduces damage.
Leviathan Leviathan The Nail The NailThe Nail Icon.png6 roomsAdds one soul heart and allows the breaking of rocks and damaging enemies by simply walking over them. Increases damage and decreases speed. All effects except for the Soul Heart wear off upon leaving the room.
Abaddon AbaddonAbaddon Icon.pngIncreases damage and speed, removes all red heart containers, grants six black hearts, and adds a chance to shoot fear tears.
Brimstone BrimstoneBrimstone Icon.pngTears are replaced by a laser beam that pierces through all enemies and obstacles in its path and deals high damage. Can only be fired after a short charge-up period.
The Mark The MarkThe Mark Icon.pngIncreases Damage and Speed, plus adds one Soul Heart.
Maw of the Void Maw of the VoidMaw of the Void Icon.png+1.0 Damage Up. After continuously firing tears for 2.5 seconds, a red cross appears on Isaac's head that, upon releasing the fire button, creates a black ring that rapidly deals damage equal to Isaac's tear damage to any enemies in contact with it.
The Pact The PactThe Pact Icon.pngIncreases damage by 0.5, tears by 0.7 and grants two soul hearts upon pickup.
Pentagram PentagramPentagram Icon.pngIncreases damage and increases the chance for a Devil or Angel Room to appear.
Spirit of the Night Spirit of the NightSpirit of the Night Icon.pngGrants spectral tears and flight.
Oh Crap Oh Crap
  • Whenever a pile of poop is destroyed, health is replenished by half a heart.
Flush! Flush!Flush! Icon.png6 roomsChanges all enemies in the room into poop. Does not work on all enemies (Knights and bosses are immune). Instantly kills Dingle, Dangle, and Brownie.
The Poop The PoopThe Poop Icon.png1 roomsSpawns a pile of poop where the character is standing and knocks nearby monsters back. May yield pickups like regular poop.
E Coli E ColiE Coli Icon.pngGives "Turdy Touch" Effect. Enemies that touch Isaac are changed into poop.
Seraphim Seraphim The Bible The BibleThe Bible Icon.png6 roomsUpon activation, Isaac gains flight, allowing him to pass over all obstacles in the current room. Instantly kills Mom, Mom's Heart, and It Lives when activated, but will kill Isaac when activated while fighting Satan.
Dead Dove Dead DoveDead Dove Icon.pngGrants spectral tears and flight.
Guardian Angel Guardian AngelGuardian Angel Icon.pngSpawns an orbital familiar that blocks enemy projectiles, deals contact damage to enemies, and increases the speed of all orbital familiars.
The Halo The HaloThe Halo Icon.pngGrants one Heart Container, +0.3 Damage, +0.2 Tears, +0.25 Range, +0.3 Speed, and +0.5 Tear Height.
Holy Grail Holy GrailHoly Grail Icon.pngGrants flight and one heart container.
Holy Mantle Holy MantleHoly Mantle Icon.pngAutomatically negates first taken damage in every room.
Mitre MitreMitre Icon.pngGrants a chance of converting any red hearts pickups into soul hearts instead.
Rosary RosaryRosary Icon.pngAdds 3 Soul Hearts and increases the chance for The Bible to appear in any item pool.
Sworn Protector Sworn ProtectorSworn Protector Icon.pngAn orbital angel which does 7 contact damage per tick and blocks enemy shots. Upon blocking 10 shots in a room it drops an eternal heart.
Spun Spun Added in Afterbirth †Adrenaline AdrenalineAdrenaline Icon.pngIncreases damage based on how many empty heart containers Isaac has.
Added in Afterbirth †Euthanasia EuthanasiaEuthanasia Icon.pngAdds a chance to fire needles. If a needle kills an enemy, it bursts into more needles.
Experimental Treatment Experimental TreatmentExperimental Treatment Icon.pngRandomly increases and decreases some of the character's stats. There will always be at least one stat increase and one decrease and the same stats can be increased/decreased multiple times.
Growth Hormones Growth HormonesGrowth Hormones Icon.pngIncreases damage by 1 and speed by 0.4.
Roid Rage Roid RageRoid Rage Icon.pngIncreases speed by 0.6, range by 5.25, and tear height by 0.5.
Speed Ball Speed BallSpeed Ball Icon.pngIncreases speed by 0.3 and shot speed by 20%.
Synthoil SynthoilSynthoil Icon.pngIncreases damage by 1, range by 5.25, and tear height by 0.5.
The Virus The VirusThe Virus Icon.pngInflicts poison to enemies who make contact with Isaac. Speed down.
Yes Mother? Yes Mother?
  • Isaac gains a stationary knife that trails directly behind him. It synergizes like Mom's Knife would.
Mom's Bottle of Pills Mom's Bottle of PillsMom's Bottle of Pills Icon.png6 roomsGives Isaac a random pill, and will cause him to drop any held Q-slot item (If any). The player will only receive six different pill types in one playthrough.
Mom's Bra Mom's BraMom's Bra Icon.png3 roomsUpon use, petrifies all enemies in the current room for approximately 4 seconds.
Mom's Pad Mom's PadMom's Pad Icon.png3 roomsUpon use, inflicts fear to all enemies in the room for 5 seconds.
Added in Afterbirth †Mom's Shovel Mom's ShovelMom's Shovel Icon.png4 roomsSpawns a trapdoor that leads to the next floor upon activation. Unlocks The Forgotten when used on a mound of dirt that appears in The Dark Room.
Mom's Coin Purse Mom's Coin PurseMom's Coin Purse Icon.pngSpawns 4 random pills around Isaac.
Mom's Contacts Mom's ContactsMom's Contacts Icon.pngAdds a chance to shoot petrifying tears, which stop enemies in place and prevent them from moving or attacking. Range up.
Mom's Eye Mom's EyeMom's Eye Icon.pngAllows Isaac to fire tears from the back of his head.
Mom's Eyeshadow Mom's EyeshadowMom's Eyeshadow Icon.pngTears have a chance to charm enemies.
Mom's Heels Mom's HeelsMom's Heels Icon.pngIncreases range.
Mom's Key Mom's KeyMom's Key Icon.pngSpawns 2 keys. Generates additional pickups from chests.
Mom's Knife Mom's KnifeMom's Knife Icon.pngIsaac's tears are replaced by a knife that pierces enemies, can travel through obstacles, and can hurt enemies while Isaac is holding it. Holding down the fire button before firing increases its range and power.
Mom's Lipstick Mom's LipstickMom's Lipstick Icon.pngIncreases range and shot height.
Mom's Pearls Mom's PearlsMom's Pearls Icon.png+1.25 Range Up. +0.5 Tear Height. +1 Luck Up.
Mom's Perfume Mom's PerfumeMom's Perfume Icon.pngAdds a chance to shoot fear tears and decreases tear delay by 1.
Mom's Purse Mom's PurseMom's Purse Icon.pngAllows Isaac to hold 1 additional trinket.
Added in Afterbirth †Mom's Razor Mom's RazorMom's Razor Icon.pngSpawns an orbiting razor that damages enemies it touches and inflicts bleeding on enemies, causing them to slowly take damage over time.
Mom's Underwear Mom's UnderwearMom's Underwear Icon.pngIncreases range.
Mom's Wig Mom's WigMom's Wig Icon.pngAdds a chance to spawn blue spiders when firing tears. Restores 1 red heart.
Super Bum Super Bum Bum Friend Bum FriendBum Friend Icon.pngA portable beggar who follows Isaac, picks up coins for himself, and occasionally drops a pickup after collecting a coin. Does not spawn collectibles.
Dark Bum Dark BumDark Bum Icon.pngSpawns a familiar that follows Isaac around and collects red hearts. For every one-and-a-half red hearts collected, Dark Bum will generate one soul heart, one hostile Spider or one friendly blue spider.
Key Bum Key BumKey Bum Icon.pngSpawns a portable key master that follows Isaac and collects keys, giving random chests in return.
1: Image depicts the familiar. This transformation does not alter Isaac's appearance.

The Binding of Isaac: Afterbirth †[edit | edit source]

Name Appearance Description Items
Bookworm Bookworm
  • Roughly 50% of the time, Isaac shoots an extra tear, like 20/20.
Anarchist Cookbook Anarchist CookbookAnarchist Cookbook Icon.png3 roomsSpawns six troll bombs around the room.
The Bible The BibleThe Bible Icon.png6 roomsUpon activation, Isaac gains flight, allowing him to pass over all obstacles in the current room. Instantly kills Mom, Mom's Heart, and It Lives when activated, but will kill Isaac when activated while fighting Satan.
The Book of Belial The Book of BelialThe Book of Belial Icon.png3 roomsUpon use increases damage by 2 for the current room and by a further +50% if the character also has the Blood of the Martyr.
Removed in Afterbirth Guarantees a Devil Room or Angel Room will be open after beating a boss while holding it, or Added in Afterbirth increases the chance by 12.5%.

Book of Revelations Book of RevelationsBook of Revelations Icon.png6 roomsAdds 1 soul heart, increases the chance for a Devil or Angel Room to appear, and increases the chance for the next boss to be a Horseman (except on XL floors and floors with fixed bosses such as Mom).
Book of Secrets Book of SecretsBook of Secrets Icon.png6 roomsUpon use, gives the effect of Treasure Map, The Compass, or Blue Map for the duration of the current floor.
Book of Shadows Book of ShadowsBook of Shadows Icon.png3 roomsUpon use, creates a protective shield nullifying all types of damage for 10 seconds.
The Book of Sin The Book of SinThe Book of Sin Icon.png4 roomsSpawns a random pickup, pill, card, or trinket.
Book of the Dead Book of the DeadBook of the Dead Icon.png4 roomsUpon use, spawns a charmed Bony or an orbital bone for each enemy killed in the current room.
How to Jump How to JumpHow to Jump Icon.pngUnlimitedGives Isaac the ability to jump (over gaps, spikes, etc.).
The Necronomicon The NecronomiconThe Necronomicon Icon.png6 roomsDamages all enemies in the room significantly.
Monster Manual Monster ManualMonster Manual Icon.png3 roomsSummons a random familiar for the current room. Can summon familiars not yet unlocked.
Satanic Bible Satanic BibleSatanic Bible Icon.png6 roomsUpon activation, Isaac gains a black heart.
Telepathy for Dummies Telepathy for DummiesTelepathy for Dummies Icon.png2 roomsUpon activation, grants homing tears for the current room.
Spider Baby Spider Baby
  • Spawns a spider familiar that applies random status effects to enemies it comes in contact with.
Box of Spiders Box of SpidersBox of Spiders Icon.png2 roomsSummons 2-4 blue spiders.
Spider Butt Spider ButtSpider Butt Icon.png2 roomsDamages all enemies in the room and slows them and their projectiles down.
Mutant Spider Mutant SpiderMutant Spider Icon.pngGrants quadruple shot but decreases tears.
Spider Baby Spider BabySpider Baby Icon.pngWhen hit, spawns up to 2 blue spiders.
Spider Bite Spider BiteSpider Bite Icon.pngAdds a chance to shoot slowing tears, reducing speed of enemy movement and any projectile fired by them.
Spider Mod Spider ModSpider Mod Icon.pngDisplays Isaac's tear damage and enemy health bars. Spawns a gray spider familiar that wanders around and inflicts a random status effect on any enemies it comes into contact with. Occasionally spawns a blue spider upon clearing a room.
Adult Adult
  • Grants a heart container.
3 X Puberty pill
Stompy None
  • Taking damage has a chance to spawn rock waves.
Leo LeoLeo Icon.pngAllows you to crush rocks when you walk over them.
Magic Mushroom Magic MushroomMagic Mushroom Icon.pngIncreases all stats and enlargens Isaac.
One Makes You Larger pill

Notes[edit | edit source]

  • Activated items (e.g. Guppy's Head Guppy's HeadGuppy's Head Icon.png1 roomsSpawns 2-4 blue flies to damage enemies.) only need to be touched in order to count. Keeping them, or even activating them once, is not required.
  • Rerolling items with a dice room, the D4 D4D4 Icon.png6 roomsRerolls all of Isaac's items., or the D100 D100D100 Icon.png6 roomsUpon use, rerolls all passive items on Isaac like the D4, every pedestal item in the room like The D6, and every pickup like the D20. will not remove progress towards the transformation.
  • Transformations can be combined with each other, keeping the effects of any and all transformations with no effects overriding others.
  • Transforming into Beelzebub for the first time will unlock the Lord of the Flies achievement.
  • Since none of the Afterbirth transformations unlock an achievement or item, attaining them is not required for 100% completion of the game in terms of achievements.
  • Many of the Afterbirth transformations override the charge animations of items such as Monstro's Lung Monstro's LungMonstro's Lung Icon.pngIncreases damage and grants a charged shot that fires multiple tears in the same fashion as Monstro. and Brimstone BrimstoneBrimstone Icon.pngTears are replaced by a laser beam that pierces through all enemies and obstacles in its path and deals high damage. Can only be fired after a short charge-up period., potentially making them more difficult to use.
    • Added in Afterbirth † There is now an option to show a charge bar that floats above Isaac.
  • Added in Afterbirth Familiars gained from Cambion Conception Cambion ConceptionCambion Conception Icon.pngAfter taking damage a certain amount of times, a permanent demonic familiar spawns. or Immaculate Conception Immaculate ConceptionImmaculate Conception Icon.pngUpon picking up a certain amount of health, spawn a permanent angelic familiar. do not count towards transformation progress.

Trivia[edit | edit source]

  • There are two transformations in the base game, nine more in the Afterbirth DLC, and four more in the Afterbirth † DLC.
  • In the original The Binding of Isaac flash game, the transformation into Guppy was the only one available, making it chronologically the first.
    • The Eternal Edition of the original The Binding of Isaac game added another transformation that turned Isaac into an angel after gaining 7 heart containers from eternal hearts.
  • Rebirth introduced Beelzebub as the chronologically second transformation.
  • The original name for the Beelzebub transformation was Lord of the Flies.

The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth
MainPageAchievements.png Achievements MainPageAttributes.png Attributes MainPageBosses.png Bosses TarotCard.png Cards and Runes MainPageChallenges.png Challenges MainPageChapters.png Chapters
Isaac App.png Characters MainPageBabies.png Co-op MainPageItems Small.png Items Item Pools Item Pools MainPageMonsters.png Monsters MainPageObjects.png Objects
Red heart.png Pickups BlueBlue.png Pills MainPageRooms.png Rooms MainPageSeeds2.png Seeds Guppy App.png Transformations The Left Hand Icon.png Trinkets