Treasure Room (Afterbirth+ Item Pool)

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Item Pool
Rebirth Treasure Room Shop Library Curse Room Boss Secret Room Devil Room Angel Room Golden Chest Red Chest Beggar Devil Beggar Key Master
Added in Afterbirth Afterbirth Treasure Room Shop Library Curse Room Boss Secret Room Devil Room Angel Room Golden Chest Red Chest Beggar Devil Beggar Key Master Bomb Bum
Added in Afterbirth Greed Mode Treasure Room Shop Library Curse Room Boss Secret Room Devil Room Angel Room Golden Chest
Added in Afterbirth † Afterbirth † Treasure Room Shop Library Curse Room Boss Secret Room Devil Room Angel Room Golden Chest Red Chest Beggar Devil Beggar Key Master Bomb Bum
Added in Afterbirth † Greed Mode Treasure Room Shop Library Curse Room Boss Secret Room Devil Room Angel Room Golden Chest

The Treasure Room item pool contains the majority of the game's items. All of the items in this pool are able to be found in the Treasure Room.

Activated Collectibles[edit | edit source]

Name ID Icon Quote Description
Anarchist Cookbook 65
Anarchist Cookbook
3 rooms
Summon bombs Spawns six troll bombs around the room.
The Bean 111
The Bean
1 rooms
Toot on command Isaac releases bad gas, poisoning any enemy in close vicinity.
Best Friend 136
Best Friend
3 rooms
Friends 'till the end Deploys a decoy Isaac that eventually explodes with an increased blast radius.
Added in Afterbirth † Black Hole 512
Black Hole
4 rooms
Nothing can escape Throws a black hole on the ground which sucks in and damages enemies.
Blank Card 286
Blank Card
4 rooms
Card Mimic Has the same effect as the card or rune currently held by Isaac.
Blood Rights 186
Blood Rights
Unlimited
Mass enemy damage at a cost Damages all enemies in the room, but deals a heart of damage to Isaac with each use.
Bob's Rotten Head 42
Bob's Rotten Head
3 rooms
Reusable ranged bomb Upon use, Isaac holds a poison bomb which can be thrown towards any of the four cardinal points and explodes on impact.
Book of Revelations 78
Book of Revelations
6 rooms
Reusable soul protection Adds 1 soul heart, increases the chance for a Devil or Angel Room to appear, and increases the chance for the next boss to be a Horseman (except on XL floors and floors with fixed bosses such as Mom).
Book of Secrets 287
Book of Secrets
6 rooms
?????? Upon use, gives the effect of Treasure Map, The Compass, or Blue Map for the duration of the current floor.
Book of Shadows 58
Book of Shadows
3 rooms
Temporary Invincibility Upon use, creates a protective shield nullifying all types of damage for 10 seconds.
The Book of Sin 97
The Book of Sin
4 rooms
Reusable Item Generator Spawns a random pickup, pill, card, or trinket.
Box of Spiders 288
Box of Spiders
2 rooms
It's a box of spiders Summons 2-4 blue spiders.
Added in Afterbirth † Book of the Dead 545
Book of the Dead
4 rooms
Rise from the grave Upon use, spawns a charmed Bony or an orbital bone for each enemy killed in the current room.
Added in Afterbirth † Brown Nugget 504
Brown Nugget
7 seconds
Friendly fly Spawns a stationary fly familiar that fires tears at nearby enemies.
Butter Bean 294
Butter Bean
3 seconds
Reusable knock-back Isaac farts and pushes back nearby enemies.
Added in Afterbirth † Clicker 482
Clicker
6 rooms
Change Transforms Isaac into another random character.
Crack the Sky 160
Crack the Sky
4 rooms
Holy white death Summons multiple beams of light in random locations around the room, dealing a large amount of damage to any enemy that touches them.
Added in Afterbirth † Crooked Penny 485
Crooked Penny
4 rooms
50/50 Spawns a penny and has a 50% chance to double all items and pickups in the room. If the effect fails, the items and pickups disappear.
Crystal Ball 158
Crystal Ball
6 rooms
I see my future Reveals the map (except the Super Secret Room) and drops a random Tarot Card or soul heart.
D100 283
D100
6 rooms
REEROLLLLL! Upon use, rerolls all passive items on Isaac like the D4, every pedestal item in the room like The D6, and every pickup like the D20.
D10 285
D10
1 rooms
Rerolls enemies Rerolls the enemies in a room. Only rerolls enemies that are still alive (does not spawn new enemies).
Added in Afterbirth D12 386
D12
3 rooms
Rerolls rocks Re-rolls all rocks in the current room into other random objects, such as bomb rocks, metal blocks, TNT, or poops.
Added in Afterbirth † D1 476
D1
4 rooms
What will it be? Duplicates a random pickup in the room.
D20 166
D20
6 rooms
Reroll the basics Rerolls all pickups in the current room.
D4 284
D4
6 rooms
Reroll into something else Rerolls all of Isaac's items.
The D6 105
The D6
6 rooms
Reroll Your Destiny Allows Isaac to re-roll collectible items in the current room into other items, depending on the current room's Item Pool.
Added in Afterbirth D7 437
D7
3 rooms
Reroll rewards! Restarts the current room and brings back all enemies, allowing more rewards to be acquired by completing the room.
Added in Afterbirth D8 406
D8
4 rooms
Reroll stats Re-rolls Isaac's speed, range, tears, and damage.
Added in Afterbirth † D Infinity 489
D Infinity
2 rooms
Reroll forever Grants a random dice item that changes each use.
Dad's Key 175
Dad's Key
2 rooms
Opens all doors... Opens all doors in the current room when activated, including doors which require a key to open and entrances to secret rooms. Opens the big doors in the first room of both The Chest and the Dark Room.
Added in Afterbirth † Dataminer 481
Dataminer
4 rooms
109 Displaces enemy sprites for the current room and increases or decreases a random stat.
Dead Sea Scrolls 124
Dead Sea Scrolls
2 rooms
It's a mystery Triggers the effect of a random activated item from a list of possible options (not every activated item is included).
Deck of Cards 85
Deck of Cards
6 rooms
Reusable Card Generator Gives Isaac a random Tarot Card.
Doctor's Remote 47
Doctor's Remote
2 rooms
Reusable Air Strike Sets a big red target on the ground (similar to the Epic Fetus item) which can be controlled with tear controls. After 6 seconds or by pressing space again, a huge explosive missile hits it, which damages all enemies caught in its blast radius.
Flush! 291
Flush!
6 rooms
... Changes all enemies in the room into poop. Does not work on all enemies (Knights and bosses are immune). Instantly kills Dingle, Dangle, and Brownie.
Forget Me Now 127
Forget Me Now
One time use
I don't remember When activated, the level ends and is freshly regenerated with new rooms, monsters, and items. Disappears after use.
Added in Afterbirth Friendly Ball 382
Friendly Ball
3 rooms
Gotta fetch 'em all! Throwing the ball at an enemy instantly kills it and captures it. The captured enemy can later be released and will be charmed until it dies, persisting between floors.
The Gamekid 93
The Gamekid
6 rooms
Temporary Man-Pac Upon use, turns the character into a into a Pac-Man-like creature for 5 seconds, granting invulnerability, inflicting fear on all enemies, and replenishing half a red heart container for every two enemies killed.
Added in Afterbirth Glass Cannon 352
Glass Cannon
4 seconds
Be gentle... When used, reduces Isaac's health to half a heart (including soul and black hearts) and fires one large piercing spectral tear that does a lot of damage. The damage done by Glass Cannon scales with Isaac's damage (at base damage it does 45 damage).
Added in Afterbirth Glowing Hour Glass 422
Glowing Hour Glass
2 rooms
Turn back time When used, this item will rewind time, put Isaac back in the previous room, and undo anything that happened in the current room. Any health, pickups, or items gained or lost will be reset back to the previous state.
The Hourglass 66
The Hourglass
2 rooms
Temporary enemy slowdown Upon activation, enemies and their projectiles are slowed down for a short duration.
How to Jump 282
How to Jump
Unlimited
It's about time you learned how Gives Isaac the ability to jump (over gaps, spikes, etc.).
Isaac's Tears 323
Isaac's Tears
6 rooms
Collected tears Shoots 8 tears around Isaac, which retain the damage, shot speed, and special effects of his tears. Each tear shot by Isaac increases item charge by one.
Kamikaze! 40
Kamikaze!
Unlimited
Become the bomb! Creates an explosion in the same area as Isaac, dealing half a heart of damage to him and also damaging all enemies caught in the blast radius.
Added in Afterbirth Kidney Bean 421
Kidney Bean
2 rooms
Love toots! Upon use, Isaac farts, charming all nearby enemies.
Lemon Mishap 56
Lemon Mishap
2 rooms
Oops Creates a small yellow pool of creep, which damages enemies that cross it.
Magic Fingers 295
Magic Fingers
Unlimited
Pay to play For 1 coin, damages all enemies in the room.
Added in Afterbirth Mega Bean 351
Mega Bean
3 rooms
Giga fart! When used, the Mega Bean will freeze all enemies in the current room for a couple of seconds, deal 5 damage and poison any enemies near Isaac, and send a wave of spikes that deals 10 damage across the room in the direction Isaac is facing.
Added in Afterbirth † Metronome 488
Metronome
2 rooms
Waggles a finger Grants a random item effect for the current room.
Added in Afterbirth Mine Crafter 427
Mine Crafter
1 rooms
Booom! When used, places an explosive TNT barrel that can be pushed and used to destroy rocks or damage enemies. If used a second time in the same room while the previous TNT barrel is still intact, it will remotely explode the TNT.
Mom's Bottle of Pills 102
Mom's Bottle of Pills
6 rooms
Reusable pill generator Gives Isaac a random pill, and will cause him to drop any held Q-slot item (If any). The player will only receive six different pill types in one playthrough.
Mom's Bra 39
Mom's Bra
3 rooms
Mass Fear Upon use, petrifies all enemies in the current room for approximately 4 seconds.
Mom's Pad 41
Mom's Pad
3 rooms
Gross... Upon use, inflicts fear to all enemies in the room for 5 seconds.
Monster Manual 123
Monster Manual
3 rooms
Temporary buddy generator Summons a random familiar for the current room. Can summon familiars not yet unlocked.
Monstro's Tooth 86
Monstro's Tooth
3 rooms
Summon Monstro Monstro jumps onto a random enemy, doing area damage. Can damage/kill the player if summoned in an room without enemies.
Mr. Boom 37
Mr. Boom
2 rooms
Reusable bomb buddy Drops a large bomb.
My Little Unicorn 77
My Little Unicorn
6 rooms
Temporary badass Upon use, grants invulnerability and increased speed for five seconds, removing the ability to shoot tears and replacing it with the ability to deal contact damage to enemies.
Notched Axe 147
Notched Axe
3 rooms
Rocks don't stand a chance Isaac holds the axe above his head for as long as the spacebar button is held (or until he leaves the room). While holding the axe, Isaac can break any rock he touches, but cannot attack or pick up other items.
Added in Afterbirth † Pause 478
Pause
2 rooms
Stop! Freezes all enemies until a fire button is pressed.
The Pinking Shears 107
The Pinking Shears
6 rooms
Cut and Run Separates Isaac's head and body for the current room. Isaac's head, which now has flight, will be under the player's control, while his body will seek out enemies to attack by contact damage.
The Poop 36
The Poop
1 rooms
Plop! Spawns a pile of poop where the character is standing and knocks nearby monsters back. May yield pickups like regular poop.
Prayer Card 146
Prayer Card
6 rooms
Reusable eternity Grants an eternal heart per use.
Remote Detonator 137
Remote Detonator
Unlimited
Remote bomb detonation Bombs you place explode only when you use this item. Gives 5 bombs.
Satanic Bible 292
Satanic Bible
6 rooms
Reusable Evil Upon activation, Isaac gains a black heart.
Scissors 325
Scissors
6 roomsAdded in Afterbirth2 rooms
Lose your head Upon use, turns Isaac's head into a stationary familiar for the current room which fires normal tears that deal 3.5 damage.
Added in Afterbirth † Sharp Straw 507
Sharp Straw
8 seconds
More blood! Damages all enemies in the room.
Shoop Da Whoop! 49
Shoop Da Whoop!
2 rooms
BLLLARRRRGGG! Fires a laser from Isaac's mouth.
Spider Butt 171
Spider Butt
2 rooms
Mass enemy slowdown + damage Damages all enemies in the room and slows them and their projectiles down.
Added in Afterbirth † Sprinkler 516
Sprinkler
4 rooms
Sprinkles. Upon use, spawns a sprinkler that rotates and fires tears.
Added in Afterbirth † Telekinesis 522
Telekinesis
3 seconds
Power of the mind Upon use, for the next two seconds, any enemy shots that come near Isaac are held in place. After the charge is depleted, they are fired back as tears.
Telepathy for Dummies 192
Telepathy for Dummies
2 rooms
Temporary psychic shot Upon activation, grants homing tears for the current room.
Teleport 44
Teleport
2 rooms
Teleport! Teleports you to a random room on the level.
Added in Afterbirth Teleport 2.0 419
Teleport 2.0
4 rooms
I-Teleport! When used, teleports Isaac to a random room that has not been explored yet. If all rooms are explored, including secret rooms, it will teleport Isaac to the Devil or Angel room. If all rooms are explored, including the Devil or Angel room, it will teleport Isaac to the I AM ERROR room. If used in a room with enemies, it will teleport Isaac out and back into the exact same room.
Undefined 324
Undefined
6 rooms
Undefined Teleports Isaac to either the Secret Room, Super Secret Room, Treasure Room, or I AM ERROR.
Unicorn Stump 298
Unicorn Stump
1 rooms
You feel stumped Upon use, grants invulnerability and increased speed for five seconds, but removes the ability to shoot tears.
Added in Afterbirth † Wait What? 484
Wait What?
10 seconds
I can't believe it's not Butter Bean! Isaac farts, sending out rock waves.
Yum Heart 45
Yum Heart
4 rooms
Reusable Regeneration Restores 1 whole red heart.

Passive Collectibles[edit | edit source]

Name ID Icon Quote Description
20/20 245 20/20 Double shot Grants double shot.
3 Dollar Bill 191 3 Dollar Bill Rainbow tears Gives Isaac a random tear effect every room.
Removed in Afterbirth The effect given changes upon entering a room.
Added in Afterbirth The effect changes every 3 seconds.
Added in Afterbirth 8 Inch Nails 359 8 Inch Nails Stick it to 'em! +1.5 Damage Up. Replaces Isaac's tears with nails, which have increased knockback.
<3 15 <3 HP up Grants Isaac one red heart container and fully restores Isaac's health.
???'s Only Friend 320 ???'s Only Friend Controlled friend Summons a big attack fly that can be controlled with the shooting direction-keys.
A Quarter 74 A Quarter +25 coins Adds 25 to Isaac's coin count, capping at 99.
Abel 188 Abel Mirrored buddy A familiar that mirrors the player's movements and shoots in the opposite direction.
Added in Afterbirth † Acid Baby 491 Acid Baby Pills pills pills! Spawns a familiar that drops random pills every 2 rooms cleared. Upon using a pill, all enemies in the room are poisoned.
Added in Afterbirth † Adrenaline 493 Adrenaline Panic = power Increases damage based on how many empty heart containers Isaac has.
Added in Afterbirth † Analog Stick 465 Analog Stick 360 tears! +0.3 tears up. Allows Isaac to fire tears diagonally.
Anemic 214 Anemic Toxic blood +5 range. After Isaac is damaged, a trail of red creep will be left behind Isaac until he leaves the current room.
Ankh 161 Ankh Eternal life? Upon death, the player will respawn as ??? with 3 soul hearts.
Added in Afterbirth † Angry Fly 511 Angry Fly He's violent Spawns a fly familiar that orbits around a random enemy and deals 5 damage per tick to enemies it comes in contact with.
Anti-Gravity 222 Anti-Gravity Antigravity tears + tears up -2 Tear Delay. Tears float in position until firing ceases, after which they will fly off in the direction they were shot in.
Added in Afterbirth † Apple! 443 Apple! Trick or treat? Increases tears. Adds a chance to fire a high-damage razor blade.
Aquarius 308 Aquarius Trail of tears A trail of blue creep is left behind Isaac, which damages enemies.
Aries 300 Aries Ramming speed +0.25 Speed. Running into enemies while at a high speed will deal 18 points of damage. Does not prevent contact damage.
BBF 272 BBF Big Beautiful Fly Spawns a familiar that flies around the room in a manner similar to the Boom Fly and explodes on contact with an enemy. Respawns after ten seconds.
Added in Afterbirth † Backstabber 506 Backstabber Watch your back! Has a chance to fire tears that inflict bleeding on enemies, causing them to slowly take damage over time.
Ball of Tar 231 Ball of Tar Sticky feet... Adds a chance to shoot slowing tears and the character leaves a trail of slowing creep behind as he moves, impeding enemies' speed.
Best Bud 274 Best Bud Sworn protector When hit, summons a white attack fly similar to Distant Admiration for the current room.
Added in Afterbirth Betrayal 391 Betrayal Turn your enemy Every time Isaac takes damage, a charm effect is applied to every enemy in the room, causing them to attack each other rather than Isaac.
Added in Afterbirth † Big Chubby 473 Big Chubby Chub chub Spawns a familiar that slowly charges forward and damages enemies in its path.
Big Fan 279 Big Fan Fat protector Spawns a large orbital familiar that blocks enemy projectiles and deals slight contact damage to enemies.
The Black Bean 180 The Black Bean Toot on touch When taking damage, Isaac farts, causing poison damage to all enemies in range.
Blood of the Martyr 7 Blood of the Martyr DMG up Increases Damage by 1, and turns Isaac's tears into blood tears.
Added in Afterbirth † Bloodshot Eye 509 Bloodshot Eye Bloody friend Spawns an orbiting eye familiar that fires tears every 2 seconds.
Bloody Lust 157 Bloody Lust RAGE! Increases damage as Isaac receives damage. Damage increase stays for the whole floor.
Bob's Brain 273 Bob's Brain Explosive thoughts Spawns a familiar that charges forward when shooting tears, explodes upon contact with an enemy and poisons them. Respawns after few seconds.
Bob's Curse 140 Bob's Curse +5 poison bombs Gives 5 bombs and grants all bombs poison effect.
Bobby-Bomb 125 Bobby-Bomb Homing bombs! Gives Isaac 5 Bombs, and causes all dropped bombs to home towards the closest enemy.
The Body 334 The Body I feel all Adds 3 heart containers.
Bomb Bag 131 Bomb Bag Gives bombs Isaac is followed by a small bag that drops a Bomb, 1+1 Free, or a Troll Bomb every 3 rooms.
Added in Afterbirth Bomber Boy 353 Bomber Boy Explosive blast! +5 bombs. Isaac's bombs will now explode in a large cross-shaped pattern (roughly 5 bombs explosions wide). This also affects troll bombs.
Boom! 19 Boom! 10 bombs Grants 10 bombs.
Added in Afterbirth † Bozo 513 Bozo Party time! Increases damage by a flat 0.1 and grants a soul heart. Enemies can randomly become briefly charmed or feared. Taking damage has a chance to spawn a rainbow poop.
Added in Afterbirth † Brittle Bones 549 Brittle Bones Everything hurts Replaces all red hearts with 6 empty bone hearts. Upon losing a bone heart, Isaac fires bones in 8 directions and permanently gains a tears up.
Brother Bobby 8 Brother Bobby Friends 'till the end Follows Isaac around shooting normal tears.
Bucket of Lard 129 Bucket of Lard HP up Grants two empty heart containers and heals Isaac by half a heart, but decreases speed by 0.2.
Bum Friend 144 Bum Friend He's greedy A portable beggar who follows Isaac, picks up coins for himself, and occasionally drops a pickup after collecting a coin. Does not spawn collectibles.
Added in Afterbirth Bumbo 385 Bumbo Bumbo want coin! Spawns a beggar familiar which floats around the room and picks up any nearby coins, leveling up after collecting several coins. At level 2, Bumbo gains a body. At level 3, it begins to fire tears. At level 4, Bumbo chases enemies slowly, dealing contact damage.
Added in Afterbirth Bursting Sack 377 Bursting Sack Spider love Spider enemies no longer target or deal contact damage to Isaac.
Butt Bombs 209 Butt Bombs Toxic blast +5 bombs Gives +5 bombs and makes all bombs Butt Bombs that fill the room with gas, damaging and confusing all enemies.
Cain's Other Eye 319 Cain's Other Eye Near sighted friend Spawns a familiar that floats slowly around the room on a zig-zag pattern similar to The Peeper and shoots normal tears in the same direction as Isaac.
Added in Afterbirth † Camo Undies 497 Camo Undies Camo kid Isaac becomes camouflaged at the beginning of each room. Enemies will not attack Isaac until he starts firing tears.
Cancer 301 Cancer HP up + you feel protected Adds 3 soul hearts. Grants The Wafer effect for the current room upon taking damage.
Capricorn 307 Capricorn All stats up All stats up.
Celtic Cross 162 Celtic Cross You feel blessed Grants a chance to trigger the Book of Shadows effect upon taking damage, creating a shield that nullifies all types of damage for 7 seconds.
Charm of the Vampire 62 Charm of the Vampire Kills heal Heals the character for half of a red heart for every 13 monsters killed.
Chemical Peel 154 Chemical Peel DMG up Tears fired from left eye do increased damage.
Chocolate Milk 69 Chocolate Milk Charge shots Grants charged tears that deal greater damage when fully charged.
The Common Cold 103 The Common Cold Poison Damage Adds a chance to shoot poison tears, dealing damage over time when inflicted.
Added in Afterbirth † Compound Fracture 453 Compound Fracture Bone tears! Increases range. Tears turn into bones, which shatter into 1-3 bone shards upon hitting an enemy or obstacle.
Added in Afterbirth † Cone Head 457 Cone Head Hard headed! Grants a soul heart. Adds a chance to block enemy shots.
Added in Afterbirth † Contagion 466 Contagion Outbreak! The first enemy killed in a room explodes and poisons nearby enemies. Poisoned enemies will also explode upon death.
Added in Afterbirth Continuum 369 Continuum Transcendent tears +2.25 Range Up. +1.5 Tear Height. Isaac's tears travel through walls and appear out of the opposite wall. Isaac's tears also travel over rocks and objects.
Cricket's Body 224 Cricket's Body Tears up + splash damage Grants -1 Tear Delay and reduces Range. When tears hit an object or deplete their range, they spawn 4 smaller tears, whose Range and Damage scale with Isaac's.
Cricket's Head 4 Cricket's Head DMG up Increases damage by 0.5, and multiplies it by 1.5x.
Cupid's Arrow 48 Cupid's Arrow Piercing shots Grants Isaac piercing tears that travel through enemies (but not obstacles) instead of breaking on impact with them.
Added in Afterbirth Curse of the Tower 371 Curse of the Tower You feel cursed... Causes Isaac to spawn 6 troll bombs on the floor every time he gets hit, similar to the Anarchist Cookbook mechanic.
Cursed Eye 316 Cursed Eye Cursed charge shot Grants charged tears that can be fired in a tight burst of four. Getting hit while charging will teleport Isaac into another room.
Daddy Longlegs 170 Daddy Longlegs Daddy's love Daddy Long Legs' shadow follows Isaac and stomps on enemies.
Dark Bum 278 Dark Bum He wants to take your life Spawns a familiar that follows Isaac around and collects red hearts. For every one-and-a-half red hearts collected, Dark Bum will generate one soul heart, one hostile Spider or one friendly blue spider.
Dead Bird 117 Dead Bird Protective buddy Spawns a flying familiar for the current room that chases enemies whenever Isaac takes damage.
Added in Afterbirth Dead Eye 373 Dead Eye Accuracy brings power! Isaac's damage increases each time an enemy is hit. Damage is reset upon missing a shot.
Dead Onion 336 Dead Onion Toxic aura tears Grants piercing and spectral tears. Increases tear size (without increasing damage) while greatly reducing range and shot speed.
Added in Afterbirth † Dead Tooth 446 Dead Tooth Halitosis While firing, Isaac gains a green aura that poisons nearby enemies.
Death's Touch 237 Death's Touch Penetrative shot + damage up Increases Damage by 1.5, reduces Tears by 0.3 and increases tear size. Grants piercing tears. Tears are replaced by Death's scythes, which is a cosmetic effect only.
Demon Baby 113 Demon Baby Auto-turret friend Follows Isaac and automatically fires at enemies in its reach.
Added in Afterbirth † Depression 469 Depression :( Spawns a cloud familiar that leaves a trail of tears that damages enemies. Has a chance to spawn damaging beams of light onto enemies that touch the cloud.
Distant Admiration 57 Distant Admiration Attack fly A red attack fly circles further out than the Halo of Flies / Pretty Flies, but closer than Forever Alone. Deals more damage than Forever Alone.
Added in Afterbirth † Dog Tooth 445 Dog Tooth Bark at the moon! Increases damage and speed. Upon entering a room adjacent to a secret room, a howl sound effect will play.
Dr. Fetus 52 Dr. Fetus ??? Tears are replaced by bombs that benefit from bomb-enhancing effects and slide a fixed range after being fired.
Dry Baby 265 Dry Baby Immortal Friend Spawns a familiar that follows Isaac around and blocks enemy projectiles. Upon blocking a shot, it has a chance of triggering The Necronomicon effect.
E Coli 236 E Coli Turdy touch Gives "Turdy Touch" Effect. Enemies that touch Isaac are changed into poop.
Added in Afterbirth Eden's Blessing 381 Eden's Blessing Your future shines brighter +0.7 tears up. Grants a random item at the start of the next run.
Epic Fetus 168 Epic Fetus On-demand air strike Isaac's tears are replaced with guided missiles, like those used by the Doctor's Remote.
Added in Afterbirth Epiphora 368 Epiphora Intensifying tears Shooting in one direction increases Isaac's rate of fire until the cap is reached. As soon as Isaac changes direction or stops shooting, rate of fire is reset to its normal amount.
Added in Afterbirth † Euthanasia 496 Euthanasia Needle shot Adds a chance to fire needles. If a needle kills an enemy, it bursts into more needles.
Eve's Mascara 310 Eve's Mascara Shot speed down + DMG up Doubles damage, halves tears stat, and greatly reduces shot speed.
Added in Afterbirth Evil Eye 410 Evil Eye Eye shot! While firing tears, Isaac has a chance to fire an eye across the screen with a very slow shot speed, which will fire tears of its own in the same direction as Isaac. The eye will be destroyed if it comes into contact with an enemy or obstacle.
Experimental Treatment 240 Experimental Treatment All stats up, then shuffled Randomly increases and decreases some of the character's stats. There will always be at least one stat increase and one decrease and the same stats can be increased/decreased multiple times.
Added in Afterbirth Explosivo 401 Explosivo Sticky bomb shot! Isaac's tears have a chance to stick to enemies and explode.
Added in Afterbirth Farting Baby 404 Farting Baby It farts! A familiar that follows Isaac and blocks tears. If a tear hits Farting Baby, there is a high chance for it to fart, which will either knock back, poison, or charm all nearby enemies.
Added in Afterbirth † Fast Bombs 517 Fast Bombs Rapid bomb drops Grants 7 bombs and allows bombs to be placed rapidly.
Added in Afterbirth Fate's Reward 361 Fate's Reward Your fate beside you A blue head familiar that will follow Isaac and fire tears copying his tear effects and damage.
Added in Afterbirth † Finger! 467 Finger! Watch where you point that! Spawns a finger familiar that points at enemies, dealing constant damage.
Fire Mind 257 Fire Mind Flaming tears Grants flaming tears that deal burning damage over time. Tears have a chance to explode on impact with an enemy, which creates a fire at the location of the explosion.
Added in Afterbirth † Flat Stone 540 Flat Stone Skipping tears Tears bounce off the floor. Tears that hit an enemy after bouncing deal splash damage to all nearby enemies for 25% of Isaac's tear damage.
Forever Alone 128 Forever Alone Attack fly Spawns a blue attack fly that orbits a long distance from Isaac.
Added in Afterbirth Friend Zone 364 Friend Zone Friendly fly A white orbiting fly which deals 3 contact damage per tick to enemies. This familiar orbits Isaac at a middle length distance somewhere between Distant Admiration and Forever Alone.
Added in Afterbirth Fruit Cake 418 Fruit Cake Rainbow effects! Isaac's tears gain a random effect that changes every shot.
Added in Afterbirth GB Bug 405 GB Bug Game breaking bug, right away! A glitch familiar that bounces around the room and applies a random status effect to any enemies it comes into contact with and has a chance to re-roll pickups that it passes over.
Gemini 318 Gemini Conjoined friend Suture becomes attached to Isaac, and does touch damage to enemies within its attacking range.
Ghost Baby 163 Ghost Baby Spectral buddy Spawns a familiar that follows Isaac around and fires spectral tears.
Added in Afterbirth † Ghost Pepper 495 Ghost Pepper Flame tears Adds a chance to shoot a fire that damages enemies and remains in place until it deals enough damage or the room is left.
Gimpy 225 Gimpy Sweet Suffering Has a chance of spawning a soul heart or black heart when taking damage. Enemies have a chance to drop a Half Red Heart after being killed.
Added in Afterbirth Glitter Bombs 432 Glitter Bombs Prize bombs! Gives Isaac 5 bombs, and makes Isaac's bombs have a chance to drop random pickups or charm enemies when they explode.
Added in Afterbirth † Glaucoma 460 Glaucoma Blind tears! Adds a chance to shoot concussive tears, causing enemies to walk around randomly.
Gnawed Leaf 210 Gnawed Leaf Unbreakable After standing still and not shooting for a short time, Isaac turns invincible until he moves or shoots.
Added in Afterbirth God's Flesh 398 God's Flesh Shrink shot Tears now have a random chance to apply a shrinking effect, causing enemies to shrink in size and also run away from Isaac. Shrunk enemies can be crushed and killed by walking over them.
Guillotine 206 Guillotine An out-of-body experience Isaac's head is removed from his body and floats around him. Increases Damage by 1 and grants -1 Tear Delay.
The Halo 101 The Halo All stats up Grants one Heart Container, +0.3 Damage, +0.2 Tears, +0.25 Range, +0.3 Speed, and +0.5 Tear Height.
Added in Afterbirth † Haemolacria 531 Haemolacria I'm seeing red... Tears are now fired in an arc. Upon hitting the floor, an obstacle, or an enemy, they burst into many smaller tears in all directions. Increases tear delay.
Added in Afterbirth † Hallowed Ground 543 Hallowed Ground Portable sanctuary Spawns a white poop familiar, which turns into a white poop when Isaac is hurt.
Halo of Flies 10 Halo of Flies Projectile protection Spawns two pretty fly familiars that block enemy shots and deal contact damage to enemies.
Harlequin Baby 167 Harlequin Baby Double shot buddy Spawns a familiar that follows Isaac around and fires two tears at once in a V-pattern.
Headless Baby 269 Headless Baby Bloody Friend Familiar that follows Isaac, leaving blood creep on the ground.
Added in Afterbirth Holy Light 374 Holy Light Holy shot! Isaac has a random chance to fire a Holy tear, which, when it hits an enemy, will spawn a Crack the Sky-style light beam on the same enemy, dealing damage.
Holy Mantle 313 Holy Mantle Holy shield Automatically negates first taken damage in every room.
Holy Water 178 Holy Water Splash! When Isaac receives damage, the bottle breaks and a puddle of blue creep forms, which damages non-flying enemies, similar to Lemon Mishap. The bottle is reformed upon entering a different room.
Added in Afterbirth Host Hat 375 Host Hat Nice hat! A host familiar that sits on Isaac's head and has a random chance to block enemy shots and retaliate with 3 tears. Grants immunity to explosions.
Hot Bombs 256 Hot Bombs Burning blast +5 bombs Grants 5 bombs. Isaac's bombs leave behind fire that damages enemies upon contact.
Added in Afterbirth † Hushy 470 Hushy Lil hush! Spawns a Hush familiar that bounces around the room and deals contact damage. While firing tears, it stops moving.
Infamy 242 Infamy Damage Reduction Chance to block projectiles coming from any direction.
Infestation 2 234 Infestation 2 Infestation shot Spawns allied blue spiders from killed enemies.
Infestation 148 Infestation They grow inside 1-3 Blue flies randomly spawn every time Isaac gets hit.
The Inner Eye 2 The Inner Eye Triple shot Grants triple shot but decreases tears.
Ipecac 149 Ipecac Explosive shots Replaces tears with explosive and poisoning projectiles fired in an arc from the mouth.
Iron Bar 201 Iron Bar Concussive tears Increases damage by 0.3 and adds a chance to shoot concussive tears, causing enemies to walk around randomly.
Isaac's Heart 276 Isaac's Heart Protect It Isaac himself is now immune to all damage, and a heart familiar appears and follows Isaac. If the heart is hurt, Isaac is hurt.
Added in Afterbirth † Jacob's Ladder 494 Jacob's Ladder Electric tears Tears fire sparks of electricity in random directions upon hitting an obstacle or enemy.
Added in Afterbirth † Jaw Bone 548 Jaw Bone Fetch! Spawns a familiar that flies the room while firing, dealing double Isaac's tear damage to enemies that come in contact and retrieving pickups.
Judas' Shadow 311 Judas' Shadow Sweet revenge Adds an extra life; upon death, it respawns Isaac as Black Judas with only two black hearts.
Juicy Sack 266 Juicy Sack Sticky babies A familiar that follows behind Isaac. It drips a trail of creep, which slows enemies, and spawns 1-2 blue spiders after each room.
Added in Afterbirth Key Bum 388 Key Bum He wants your keys! Spawns a portable key master that follows Isaac and collects keys, giving random chests in return.
Added in Afterbirth Kidney Stone 440 Kidney Stone Matt's kidney stone Randomly while firing tears, Isaac will stop firing and turn red, where he will charge and release a lot of 'tears' in one go. In the burst of tears is a kidney stone which deals a lot of damage.
Added in Afterbirth † Lachryphagy 532 Lachryphagy Feed them! Isaac's tears decelerate as they travel. Upon stopping or hitting an obstacle, they burst into 8 tears in all directions. Tears can be fired into other tears to feed them, increasing their damage.
Added in Afterbirth † Large Zit 502 Large Zit Creep shots Adds a chance to fire a creep shot that deals double damage and leaves a trail of slowing white creep.
Lazarus' Rags 332 Lazarus' Rags Eternal Life? Upon dying, resurrect as Revived Lazarus with one heart container and Anemic item.
Added in Afterbirth † Lead Pencil 444 Lead Pencil He's a bleeder! After every 15 tears fired, Isaac will fire a high-damage cluster of tears.
Leech 270 Leech Blood sucker Spawns a friendly familiar leech on the ground that hunts down enemies and heals you for half a heart each time it eats one.
Leo 302 Leo Stompy Allows you to crush rocks when you walk over them.
Added in Afterbirth † Leprosy 525 Leprosy You're tearing me apart! Upon taking damage, grants a body part as an orbital, which blocks enemy shots and deals 7 damage per tick to enemies it comes in contact with. The orbitals will be destroyed if they take enough damage from enemies or enemy shots.
Libra 304 Libra You Feel Balanced Gives 6 coins, 6 bombs, and 6 keys and balances out all attributes.
Added in Afterbirth Lil Chest 362 Lil Chest What's in the box? Spawns a chest familiar that follows Isaac and drops a random pickup every few rooms.
Added in Afterbirth Lil Gurdy 384 Lil Gurdy A gurd of your own! Gives Isaac a Gurdy familiar that will charge around the room dealing contact damage to enemies. Lil Gurdy is charged by holding down a fire button and letting go. The longer the button is held, the faster Lil Gurdy will fling itself across the screen. Lil Gurdy can pass over objects and obstacles in the room.
Added in Afterbirth Lil' Loki 435 Lil' Loki 4-way buddy! A Loki familiar that follows Isaac and shoots 4 tears in a cross pattern.
Added in Afterbirth † Lil Monstro 471 Lil Monstro Ain't he cute? Spawns a familiar that fires clusters of tears. Must be charged before shooting.
Lil Brimstone 275 Lil Brimstone Evil Friend A Familiar that shoots a thin Brimstone beam. Must charge like Brimstone before shooting.
Lil Haunt 277 Lil Haunt Fear him A familiar that damages enemies by chasing them as well as inducing the fear effect.
Added in Afterbirth † Lil Spewer 537 Lil Spewer Puking buddy Spawns a random pill, and grants a small Spewer familiar that charges up and fires different types of creep.
Added in Afterbirth † Linger Bean 447 Linger Bean Crying makes me toot Adds a chance to fire a gas cloud that damages nearby enemies.
Little C.H.A.D. 96 Little C.H.A.D. Gives kisses A familiar who will drop a half red heart every 2 rooms.
Little Chubby 88 Little Chubby Attack Buddy A familiar that charges forward and deals touch damage to any enemies in its path.
Little Gish 99 Little Gish Sticky friend Spawns a familiar that follows Isaac around and fires slowing tears, impeding enemies' speed.
Little Steven 100 Little Steven Psychic friend Spawns a familiar that follows Isaac around and fires homing tears.
Loki's Horns 87 Loki's Horns Cross Tears Gives a random chance for projectiles to fire in all 4 cardinal directions.
Lost Contact 213 Lost Contact Shielded tears Every tear has a small shield which will allow it to block one enemy projectile.
Added in Afterbirth Lost Fly 365 Lost Fly Lost protector A familiar fly that moves in a straight line and attaches itself to the first obstacle or wall it comes into contact with in each room. If any enemies walk into its path, it will deal 7 contact damage per tick. If the obstacle it is attached to is destroyed then it will continue rolling in the direction it was previously travelling until it meets another wall or obstacle.
Lucky Foot 46 Lucky Foot Luck up +1 Luck. Increases chance of winning Shell Game Beggar. (Independent of luck stat)
The Ludovico Technique 329 The Ludovico Technique Controlled Tears Instead of firing tears, Isaac controls one floating tear that hover over obstacles. This tear deals constant damage when held in place over an enemy.
Added in Afterbirth Lusty Blood 411 Lusty Blood Their blood brings rage! Each time Isaac kills an enemy, Isaac's damage increases for the current room.
Maggy's Bow 312 Maggy's Bow HP up + you feel healthy Gives one heart container and doubles the healing provided by red hearts.
Magic Mushroom 12 Magic Mushroom All Stats Up! Increases all stats and enlargens Isaac.
Magneto 53 Magneto Item snatcher Pulls pickups towards Isaac.
Added in Afterbirth Marked 394 Marked Directed tears Isaac will now fire tears automatically directed at a red target on the ground which is controlled by the player. This allows for a full 360 degree tear firing radius. Can be overridden by other tear modifiers such as Mom's Knife or Brimstone.
Added in Afterbirth † Metal Plate 449 Metal Plate It itches... Adds a chance to reflect enemy shots. Grants one soul heart.
Midas' Touch 202 Midas' Touch Golden touch Enemies that touch you are stunned and turn gold. Any enemy killed while in this state will drop a coin.
Added in Afterbirth Milk! 436 Milk! Don't cry over it... A glass of milk follows Isaac and spills on the floor upon taking damage. After the milk spills, Isaac's tear delay is decreased by 2 for the rest of the room.
The Mind 333 The Mind I know all Grants the combined effects of the Blue Map, Treasure Map, and The Compass, revealing the floor layout and all special rooms, including Secret Rooms and Super Secret Rooms.
Mini Mush 71 Mini Mush Speed + range up Increases Speed and Shot Height and decreases Isaac's size, but lowers Range.
Mitre 173 Mitre You Feel Blessed Grants a chance of converting any red hearts pickups into soul hearts instead.
Mom's Contacts 110 Mom's Contacts Freeze effect Adds a chance to shoot petrifying tears, which stop enemies in place and prevent them from moving or attacking. Range up.
Mom's Eyeshadow 200 Mom's Eyeshadow Charm tears Tears have a chance to charm enemies.
Mom's Eye 55 Mom's Eye Eye in the back of your head Allows Isaac to fire tears from the back of his head.
Mom's Knife 114 Mom's Knife Stab stab stab Isaac's tears are replaced by a knife that pierces enemies, can travel through obstacles, and can hurt enemies while Isaac is holding it. Holding down the fire button before firing increases its range and power.
Mom's Perfume 228 Mom's Perfume Fear shot Adds a chance to shoot fear tears and decreases tear delay by 1.
Added in Afterbirth † Mom's Razor 508 Mom's Razor It's sharp! Spawns an orbiting razor that damages enemies it touches and inflicts bleeding on enemies, causing them to slowly take damage over time.
Mom's Wig 217 Mom's Wig You feel itchy... Adds a chance to spawn blue spiders when firing tears. Restores 1 red heart.
Money = Power 109 Money = Power $$$ = DMG Increases damage by 0.04 for every coin Isaac has, up to +3.96 damage at 99 coins.
Mongo Baby 322 Mongo Baby Mongo Friend Summons a familiar that copies the tears of Isaac's other familiars.
Monstro's Lung 229 Monstro's Lung Charged attack Increases damage and grants a charged shot that fires multiple tears in the same fashion as Monstro.
Mr. Mega 106 Mr. Mega Blast damage Gives Isaac 5 bombs, and makes all dropped bombs larger, which have an increased blast radius and increased damage.
The Mulligan 151 The Mulligan They grow inside Tears have a 1/6 chance of spawning allied blue flies when they hit an enemy.
Added in Afterbirth Multidimensional Baby 431 Multidimensional Baby ydduB Buddy Spawns a familiar that will follow Isaac's movements on a 2.5 second delay. Tears that pass through the baby will be doubled and increase in speed.
Mutant Spider 153 Mutant Spider Quad shot Grants quadruple shot but decreases tears.
My Reflection 5 My Reflection Boomerang tears Gives Isaac's tears a boomerang effect, and increases range and shot speed.
Mysterious Liquid 317 Mysterious Liquid Toxic Splash Damage Tears leave a small, short lasting pool of creep on impact or when their range is depleted.
Added in Afterbirth † Mystery Egg 539 Mystery Egg Sacrificial insemination Spawns an egg familiar, which cracks and turns into a random charmed enemy when Isaac is hurt. The egg regenerates upon entering a different room.
Mystery Sack 271 Mystery Sack ? Spawns a familiar that follows Isaac around and has a chance to drop a heart, coin, bomb, or key after clearing a room.
Added in Afterbirth No. 2 378 No. 2 Uh oh... Continuously firing tears for several seconds causes Isaac to drop a Butt Bomb. Butt Bombs explode for 50 damage like normal bombs, but also deal 10 damage to all enemies in the room and daze them for a short period of time.
Number One 6 Number One Tears up +1.5 tears, -15.77 range
Added in Afterbirth Obsessed Fan 426 Obsessed Fan Follows my every move... A purple fly familiar that follows Isaac's movements on a 3 second delay and deals contact damage to enemies.
Odd Mushroom 121 Odd Mushroom DMG up Grants an empty heart container. Increases damage, range and shot height while reducing speed.
Odd Mushroom 120 Odd Mushroom Fire rate up +1.7 tears, +0.3 speed, reduces damage.
Ouija Board 115 Ouija Board Spectral tears Grants spectral tears that travel through obstacles (but not enemies) instead of breaking on impact with them.
PHD 75 PHD Better pills Converts all bad pills into good pills, spawns one pill pickup and restores health. Identifies all pills upon pickup.
Added in Afterbirth Papa Fly 430 Papa Fly Turret follower A blue fly familiar follows Isaac's movements on a 3 second delay. Papa Fly will fire tears at nearby enemies.
The Parasite 104 The Parasite Split Shot Isaac's tears split in two when they hit something.
Added in Afterbirth † Parasitoid 461 Parasitoid Egg tears! Adds a chance to fire an egg sack which spawns slowing creep and spawns a blue fly or spider upon hitting an enemy.
The Peeper 155 The Peeper Plop! Spawns a familiar that floats slowly around the room on a zig-zag pattern similar to Boom Flies damaging enemies it passes through.
Piggy Bank 227 Piggy Bank My life savings Gives 3 pennies on pick-up. Every time Isaac is damaged, he will drop one additional penny.
Pisces 309 Pisces Tears up + knock-back shots -1 Tear Delay, adds knock-back shots and increases tear size.
Added in Afterbirth † Pointy Rib 544 Pointy Rib Stabbing time Spawns a bone familiar that can be aimed with the fire buttons and does contact damage.
Polyphemus 169 Polyphemus Mega Tears Makes Isaac shoot one huge tear. Also reduces Tears to minimum. Damage increased . If tear does more damage than an enemy's life, the tear continues to travel with the extra remaining damage.
Added in Afterbirth † Pop! 529 Pop! Eyeball tears! Replaces Isaac's tears with eyeballs that can bounce off of each other. The eyeballs are not limited by range, and will instead dissipate when they stop moving or when hitting an enemy or obstacle.
Proptosis 261 Proptosis Short range mega tears Tears start out massive with high damage, and then shrink down and become weaker over a short range.
Punching Bag 281 Punching Bag Scape Goat Spawns a Mulligan Familiar that will wander the room randomly. Enemies will attack the Mulligan if it's closer.
Added in Afterbirth Pupula Duplex 379 Pupula Duplex Wide shot Transforms Isaac's tears into a wide arc shape which gives them a much larger hitbox. Gives Isaac spectral tears which allows them to travel through objects in the environment (i.e. rocks).}
Added in Afterbirth Purity 407 Purity Aura stat boost This item will boost one of Isaac's stats depending on the color of the aura around him. The aura will disappear upon taking damage and will reappear with a random color upon entering a new room. A red aura boosts damage, a blue aura boosts rate of fire, a yellow aura boosts speed, and an orange aura boosts range.
Pyromaniac 223 Pyromaniac It hurts so good +5 Bombs Isaac heals 1 heart instead of taking damage from an explosive source. Adds 5 bombs.
Pyro 190 Pyro 99 bombs Adds 99 bombs.
Rainbow Baby 174 Rainbow Baby Random buddy Spawns a familiar that follows Isaac around and fires tears with random effects.
The Relic 98 The Relic Soul generator Isaac is followed by a small blue cross that will drop a Soul Heart every 4 rooms.
Robo-Baby 2.0 267 Robo-Baby 2.0 We worked out all the kinks Fires lasers at any enemy in its line of sight and moves based on the direction Isaac is firing tears.
Robo-Baby 95 Robo-Baby Friends 'till the bbbbzzzt Follows Isaac around, shooting enemies with an eye laser similar to Technology.
Roid Rage 14 Roid Rage Speed and range up Increases speed by 0.6, range by 5.25, and tear height by 0.5.
Rosary 72 Rosary Faith up Adds 3 Soul Hearts and increases the chance for The Bible to appear in any item pool.
Rotten Baby 268 Rotten Baby Infested friend A familiar that spawns blue flies.
Rubber Cement 221 Rubber Cement Bouncing tears Tears bounce off walls, enemies, and environmental objects.
Added in Afterbirth Rune Bag 389 Rune Bag Rune generator A bag that follows Isaac and drops a random rune every 3 rooms.
Sack of Pennies 94 Sack of Pennies Gives money Isaac is followed by a small bag that drops a coin every 2 rooms.
Sacrificial Dagger 172 Sacrificial Dagger My fate protects me Dagger orbits Isaac, dealing very high damage.
Sad Bombs 220 Sad Bombs Tear blast +5 bombs +5 Bombs. Upon exploding, bombs shoot 8 tears off in every direction, similar to Tammy's Head. The tears are affected by any tear modifiers Isaac has on his own tears.
The Sad Onion 1 The Sad Onion Tears up Increases Tears by 0.7.
Sagittarius 306 Sagittarius Penetrative shot + speed up Increases speed by +0.2 and grants piercing tears.
Samson's Chains 321 Samson's Chains The ol' ball and chain Pull a chain and ball behind you that will damage enemies on contact and is able to break stones.
Scapular 142 Scapular You have been blessed Once per room, when Isaac is reduced to his last half red Heart, the aura around his head temporarily vanishes and he is granted one Soul Heart.
Added in Afterbirth Scatter Bombs 366 Scatter Bombs 'We put bombs in your bombs!' Adds 5 bombs. Isaac's bombs explode into 2-4 tiny bombs
Scorpio 305 Scorpio Poison tears Grants poison tears, which deal damage over time when inflicted.
Added in Afterbirth Seraphim 390 Seraphim Sworn friend An angel familiar which follows Isaac and fires homing tears which deal 10 damage at -25% shot speed and a reduced fire rate.
Added in Afterbirth Serpent's Kiss 393 Serpent's Kiss The kiss of death Tears now have a random chance to apply a poison effect, causing 4 or 6 damage per tick to enemies (Similar to The Common Cold item). Isaac now deals poison damage on contact with enemies similar to The Virus item (Damage over time 4 or 6 per tick). Enemies that were poisoned have a chance to drop a black heart when killed.
Added in Afterbirth † Shard of Glass 448 Shard of Glass Blood and guts! Upon taking damage, Isaac has a chance to drop a full red heart, gain 5 range, and leave a trail of damaging red creep for the current room.
Added in Afterbirth † Sinus Infection 459 Sinus Infection Booger tears! Adds a chance to fire a booger which sticks to enemies and poisons them.
Sissy Longlegs 280 Sissy Longlegs She loves you Wanders about the room, occasionally spawning blue spiders.
Sister Maggy 67 Sister Maggy Friends 'till the end A familiar that follows Isaac around shooting blood tears.
Added in Afterbirth † Slipped Rib 542 Slipped Rib Projectile shield Spawns a bone familiar that circles around Isaac and reflects enemy shots.
Smart Fly 264 Smart Fly Revenge fly After Isaac takes damage, this fly will deal continuous touch damage to whatever enemy caused the damage until it is dead. The fly will then systematically attack 1 enemy at a time until the room is cleared.
SMB Super Fan 189 SMB Super Fan All stats up Increases all stats.
The Soul 335 The Soul I am all Grants two soul hearts. Isaac now repels enemy projectiles.
Soy Milk 330 Soy Milk DMG Down + Tears Way Up Tears shrink and do much less damage, but fire in very rapid succession.
Speed Ball 143 Speed Ball Speed + shot speed up Increases speed by 0.3 and shot speed by 20%.
Spelunker Hat 91 Spelunker Hat See-through doors Reveals type of adjacent rooms, including location for secret rooms and super secret rooms.
Spider Bite 89 Spider Bite Slow effect Adds a chance to shoot slowing tears, reducing speed of enemy movement and any projectile fired by them.
Spider Baby 211 Spider Baby Spider revenge When hit, spawns up to 2 blue spiders.
Spoon Bender 3 Spoon Bender Homing shots Grants Isaac homing tears.
Stem Cells 176 Stem Cells HP up Adds one filled heart container and increases Shot Speed.
Added in Afterbirth Sticky Bombs 367 Sticky Bombs Egg sack bombs! +5 bombs. Bombs stick to enemies and spawn 2-4 blue spiders if they kill an enemy.
Stigmata 138 Stigmata DMG + HP up Increases damage, and adds 1 heart container.
Strange Attractor 315 Strange Attractor Magnetic tears Pickups, trinkets, and monsters are magnetically attracted to Isaac's tears.
Added in Afterbirth † Sulfuric Acid 463 Sulfuric Acid Acid tears! Increases damage. Adds a chance to fire acidic tears which can destroy obstacles.
Super Bandage 92 Super Bandage +2 hearts Grants one Heart Container and gives 2 Soul Hearts.
Taurus 299 Taurus Speed down + rage is building Speed down; gains speed while in a room with enemies until gaining My Little Unicorn effect for a few seconds.
Added in Afterbirth Tech X 395 Tech X Laser ring tears Tears are replaced with laser rings that pierce through enemies and deal damage to enemies within them. Can be charged to increase the size of the ring.
Tech.5 244 Tech.5 It's still being tested... Grants a unlimited range piercing laser with random rate of fire that does not replace tears. The laser might occasionally fire with the effect of a random item or trinket, such as Hook Worm, Spoon Bender or Tiny Planet.
Technology 2 152 Technology 2 Laser Decreases damage and replaces right eye tears with a unlimited range, piercing laser which fires continuously.
Technology 68 Technology Laser tears Replaces tears with a piercing laser with unlimited range.
Added in Afterbirth † Technology Zero 524 Technology Zero Static tears! Connects Isaac's tears with electricity that can damage enemies.
Thunder Thighs 314 Thunder Thighs HP up + speed down + you feel stompy Destroys rocks upon contact with Isaac. Adds one heart container and lowers Speed.
Tiny Planet 233 Tiny Planet Orbiting tears + range up Range up and makes shot tears revolve around Isaac until they drop.
Tough Love 150 Tough Love Tooth shot Adds a chance to shoot a tooth instead of a tear, which deals greater damage than regular tears.
Added in Afterbirth Toxic Shock 350 Toxic Shock Mass poison Upon entering a room, poisons all enemies, dealing double Isaac's tear damage. Killing enemies leaves a small, short lasting pool of green creep on the ground.
Added in Afterbirth Tractor Beam 397 Tractor Beam Control your tears Isaac emits a beam from his face. Isaac's tears travel in the path of the beam.
Added in Afterbirth † Varicose Veins 452 Varicose Veins I'm leaking... Taking damage releases a ring of 10 high damage tears.
Virgo 303 Virgo You feel refreshed and protected Grants a chance to trigger the Book of Shadows effect upon taking damage, creating a shield that nullifies all types of damage for 10 seconds. Also converts "bad pills" into "good pills".
The Virus 13 The Virus Poison touch Inflicts poison to enemies who make contact with Isaac. Speed down.
The Wafer 108 The Wafer Damage resistance All sources of damage that would cause more than one half heart of damage are reduced to one half heart instead.
Added in Afterbirth The Wiz 358 The Wiz Double wiz shot! Tears simultaneously fire out of both eyes diagonally, similar to the effect of the R U A Wizard? pill. Isaac's tears also travel above all obstacles.
X-Ray Vision 76 X-Ray Vision I've seen everything Reveals and opens all Secret Room and Super Secret Room entrances.
Added in Afterbirth † YO LISTEN! 492 YO LISTEN! Yo listen! Increases luck. Spawns a fairy familiar that points out secret room entrances and tinted rocks.
Added in Afterbirth Zodiac 392 Zodiac The heavens will change you Zodiac will give Isaac a random zodiac item effect that changes after every floor.


The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth
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