Treasure Room (Greed Mode Item Pool)

Item Pool
Rebirth	Treasure Room	Shop	Library	Curse Room	Boss	Secret Room	Devil Room	Angel Room	Golden Chest	Red Chest	Beggar	Devil Beggar	Key Master
Afterbirth	Treasure Room	Shop	Library	Curse Room	Boss	Secret Room	Devil Room	Angel Room	Golden Chest	Red Chest	Beggar	Devil Beggar	Key Master	Bomb Bum
Greed Mode	Treasure Room	Shop	Library	Curse Room	Boss	Secret Room	Devil Room	Angel Room	Golden Chest
Afterbirth †	Treasure Room	Shop	Library	Curse Room	Boss	Secret Room	Devil Room	Angel Room	Golden Chest	Red Chest	Beggar	Devil Beggar	Key Master	Bomb Bum
Greed Mode	Treasure Room	Shop	Library	Curse Room	Boss	Secret Room	Devil Room	Angel Room	Golden Chest

All of the items in this pool can be found in the gold Treasure Room in Greed Mode. They can also occasionally be found in the Greed Mode Shop.

Activated Collectibles

Name	ID	Icon	Quote	Description
Anarchist Cookbook	65		Summon bombs	Spawns six troll bombs around the room.
The Bean	111		Toot on command	Isaac releases bad gas, poisoning any enemy in close vicinity.
Blood Rights	186		Mass enemy damage at a cost	Damages all enemies in the room, but deals a heart of damage to Isaac with each use.
Bob's Rotten Head	42		Reusable ranged bomb	Upon use, Isaac holds a poison bomb which can be thrown towards any of the four cardinal points and explodes on impact.
The Book of Belial	34		Temporary DMG up	Upon use increases damage by 2 for the current room and by a further +50% if the character also has the Blood of the Martyr. Guarantees a Devil Room or Angel Room will be open after beating a boss while holding it, or increases the chance by 12.5%.
The Book of Sin	97		Reusable Item Generator	Spawns a random pickup, pill, card, or trinket.
Book of Revelations	78		Reusable soul protection	Adds 1 soul heart, increases the chance for a Devil or Angel Room to appear, and increases the chance for the next boss to be a Horseman (except on XL floors and floors with fixed bosses such as Mom).
Box of Friends	357		Double your friends	Upon use, duplicates all of Isaac's familiars for the current room.
Box of Spiders	288		It's a box of spiders	Summons 2-4 blue spiders.
Dad's Key	175		Opens all doors...	Opens all doors in the current room when activated, including doors which require a key to open and entrances to secret rooms. Opens the big doors in the first room of both The Chest and the Dark Room.
Dead Sea Scrolls	124		It's a mystery	Triggers the effect of a random activated item from a list of possible options (not every activated item is included).
Deck of Cards	85		Reusable Card Generator	Gives Isaac a random Tarot Card.
Doctor's Remote	47		Reusable Air Strike	Sets a big red target on the ground (similar to the Epic Fetus item) which can be controlled with tear controls. After 6 seconds or by pressing space again, a huge explosive missile hits it, which damages all enemies caught in its blast radius.
Flush!	291		...	Changes all enemies in the room into poop. Does not work on all enemies (Knights and bosses are immune). Instantly kills Dingle, Dangle, and Brownie.
Friendly Ball	382		Gotta fetch 'em all!	Throwing the ball at an enemy instantly kills it and captures it. The captured enemy can later be released and will be charmed until it dies, persisting between floors.
The Gamekid	93		Temporary Man-Pac	Upon use, turns the character into a into a Pac-Man-like creature for 5 seconds, granting invulnerability, inflicting fear on all enemies, and replenishing half a red heart container for every two enemies killed.
Glass Cannon	352		Be gentle...	When used, reduces Isaac's health to half a heart (including soul and black hearts) and fires one large piercing spectral tear that does a lot of damage. The damage done by Glass Cannon scales with Isaac's damage (at base damage it does 45 damage).
Jar of Flies	434		Gotta catch 'em all?	Every time Isaac kills an enemy, a fly will be added to the jar, up to a maximum of 20. Using the Jar of Flies will release all the flies that are currently in the jar as friendly blue flies that will damage enemies.
Kidney Bean	421		Love toots!	Upon use, Isaac farts, charming all nearby enemies.
Lemon Mishap	56		Oops...	Creates a small yellow pool of creep, which damages enemies that cross it.
Mega Bean	351		Giga fart!	When used, the Mega Bean will freeze all enemies in the current room for a couple of seconds, deal 5 damage and poison any enemies near Isaac, and send a wave of spikes that deals 10 damage across the room in the direction Isaac is facing.
Mom's Bottle of Pills	102		Reusable pill generator	Gives Isaac a random pill, and will cause him to drop any held Q-slot item (If any). The player will only receive six different pill types in one playthrough.
Mr. Boom	37		Reusable bomb buddy	Drops a large bomb.
My Little Unicorn	77		Temporary badass	Upon use, grants invulnerability and increased speed for five seconds, removing the ability to shoot tears and replacing it with the ability to deal contact damage to enemies.
The Necronomicon	35		Mass room damage	Damages all enemies in the room significantly.
The Pinking Shears	107		Cut and Run	Separates Isaac's head and body for the current room. Isaac's head, which now has flight, will be under the player's control, while his body will seek out enemies to attack by contact damage.
Prayer Card	146		Reusable eternity	Grants an eternal heart per use.
Remote Detonator	137		Remote bomb detonation	Bombs you place explode only when you use this item. Gives 5 bombs.
Scissors	325		Lose your head	Upon use, turns Isaac's head into a stationary familiar for the current room which fires normal tears that deal 3.5 damage.
Tammy's Head	38		Reusable tear burst	Shoots 10 tears in a circle around Isaac, which retain the damage, shot speed, and special effects (such as poison) of Isaac's tears.
Tear Detonator	383		Remote tear detonation!	When used, will detonate any tears currently on the screen and cause each one to split into 6 more tears which will fire in a circle, similar to Tammy's Head.
Telepathy for Dummies	192		Temporary psychic shot	Upon activation, grants homing tears for the current room.
Wooden Nickel	349		Flip a coin	When used, has a 50% chance to drop one random type of coin (penny, nickel, or dime).
Yum Heart	45		Reusable Regeneration	Restores 1 whole red heart.

Passive Collectibles

Name	ID	Icon	Quote	Description
20/20	245		Double shot	Grants double shot.
3 Dollar Bill	191		Rainbow tears	Gives Isaac a random tear effect every room. The effect given changes upon entering a room. The effect changes every 3 seconds.
8 Inch Nails	359		Stick it to 'em!	+1.5 Damage Up. Replaces Isaac's tears with nails, which have increased knockback.
???'s Only Friend	320		Controlled friend	Summons a big attack fly that can be controlled with the shooting direction-keys.
A Lump of Coal	132		My Xmas Present	The more distance tears travel, the more damage they will do.
Abel	188		Mirrored buddy	A familiar that mirrors the player's movements and shoots in the opposite direction.
Anemic	214		Toxic blood	+5 range. After Isaac is damaged, a trail of red creep will be left behind Isaac until he leaves the current room.
Ankh	161		Eternal life?	Upon death, the player will respawn as ??? with 3 soul hearts.
Anti-Gravity	222		Antigravity tears + tears up	-2 Tear Delay. Tears float in position until firing ceases, after which they will fly off in the direction they were shot in.
Aquarius	308		Trail of tears	A trail of blue creep is left behind Isaac, which damages enemies.
Aries	300		Ramming speed	+0.25 Speed. Running into enemies while at a high speed will deal 18 points of damage. Does not prevent contact damage.
Ball of Tar	231		Sticky feet...	Adds a chance to shoot slowing tears and the character leaves a trail of slowing creep behind as he moves, impeding enemies' speed.
Best Bud	274		Sworn protector	When hit, summons a white attack fly similar to Distant Admiration for the current room.
Betrayal	391		Turn your enemy	Every time Isaac takes damage, a charm effect is applied to every enemy in the room, causing them to attack each other rather than Isaac.
Big Fan	279		Fat protector	Spawns a large orbital familiar that blocks enemy projectiles and deals slight contact damage to enemies.
Black Lotus	226		HP up x3!	Grants the player one red heart container, one soul heart, and one black heart.
Blood Clot	254		DMG + range up	Increases damage by 1 and range by 5 for tears fired from the left eye.
Blood of the Martyr	7		DMG up	Increases Damage by 1, and turns Isaac's tears into blood tears.
Bloody Lust	157		RAGE!	Increases damage as Isaac receives damage. Damage increase stays for the whole floor.
Bob's Brain	273		Explosive thoughts	Spawns a familiar that charges forward when shooting tears and explodes upon contact with an enemy, damaging and poisoning them. The familiar respawns after a few seconds.
Bob's Curse	140		+5 poison bombs	Gives 5 bombs and grants all bombs poison effect.
Bobby-Bomb	125		Homing bombs!	Gives Isaac 5 Bombs, and causes all dropped bombs to home towards the closest enemy.
The Body	334		I feel all	Adds 3 heart containers.
Bomb Bag	131		Gives bombs	Isaac is followed by a small bag that drops a Bomb, 1+1 Free, or a Troll Bomb every 3 rooms.
Bomber Boy	353		Explosive blast!	+5 bombs. Isaac's bombs will now explode in a large cross-shaped pattern (roughly 5 bombs explosions wide). This also affects troll bombs.
Brother Bobby	8		Friends 'till the end	Follows Isaac around shooting normal tears.
Bursting Sack	377		Spider love	Spider enemies no longer target or deal contact damage to Isaac.
Butt Bombs	209		Toxic blast +5 bombs	Gives +5 bombs and makes all bombs Butt Bombs that fill the room with gas, damaging and confusing all enemies.
Cain's Other Eye	319		Near sighted friend	Spawns a familiar that floats slowly around the room on a zig-zag pattern similar to The Peeper and shoots normal tears in the same direction as Isaac.
Cancer	301		HP up + you feel protected	Adds 3 soul hearts. Grants The Wafer effect for the current room upon taking damage.
Capricorn	307		All stats up	All stats up.
Celtic Cross	162		You feel blessed	Grants a chance to trigger the Book of Shadows effect upon taking damage, creating a shield that nullifies all types of damage for 7 seconds.
Charm of the Vampire	62		Kills heal	Heals the character for half of a red heart for every 13 monsters killed.
Chemical Peel	154		DMG up	Tears fired from left eye do increased damage.
Chocolate Milk	69		Charge shots	Grants charged tears that deal greater damage when fully charged.
The Common Cold	103		Poison Damage	Adds a chance to shoot poison tears, dealing damage over time when inflicted.
Continuum	369		Transcendent tears	+2.25 Range Up. +1.5 Tear Height. Isaac's tears travel through walls and appear out of the opposite wall. Isaac's tears also travel over rocks and objects.
Cricket's Body	224		Tears up + splash damage	Grants -1 Tear Delay and reduces Range. When tears hit an object or deplete their range, they spawn 4 smaller tears, whose Range and Damage scale with Isaac's.
Cricket's Head	4		DMG up	Increases damage by 0.5, and multiplies it by 1.5x.
Cube of Meat	73		Gotta meat 'em all!	Orbiting familiar that blocks enemy shots and deals damage to enemies. If collected while already having one, makes the familiar evolve. Only drops from Horsemen. Similar to Ball of Bandages.
Cupid's Arrow	48		Piercing shots	Grants Isaac piercing tears that travel through enemies (but not obstacles) instead of breaking on impact with them.
Curse of the Tower	371		You feel cursed...	Causes Isaac to spawn 6 troll bombs on the floor every time he gets hit, similar to the Anarchist Cookbook mechanic.
Cursed Eye	316		Cursed charge shot	Grants charged tears that can be fired in a tight burst of four. Getting hit while charging will teleport Isaac into another room.
Daddy Longlegs	170		Daddy's love	Daddy Long Legs' shadow follows Isaac and stomps on enemies.
Dead Bird	117		Protective buddy	Spawns a flying familiar for the current room that chases enemies whenever Isaac takes damage.
Dead Eye	373		Accuracy brings power!	Isaac's damage increases each time an enemy is hit. Damage is reset upon missing a shot.
Dead Onion	336		Toxic aura tears	Grants piercing and spectral tears. Increases tear size (without increasing damage) while greatly reducing range and shot speed.
Death's Touch	237		Penetrative shot + damage up	Increases Damage by 1.5, reduces Tears by 0.3 and increases tear size. Grants piercing tears. Tears are replaced by Death's scythes, which is a cosmetic effect only.
Deep Pockets	416		More stuff to carry!	Allows Isaac to carry two cards or pills (or a combination of both) at the same time.
Distant Admiration	57		Attack fly	A red attack fly circles further out than the Halo of Flies / Pretty Flies, but closer than Forever Alone. Deals more damage than Forever Alone.
Dr. Fetus	52		???	Tears are replaced by bombs that benefit from bomb-enhancing effects and slide a fixed range after being fired.
Dry Baby	265		Immortal Friend	Spawns a familiar that follows Isaac around and blocks enemy projectiles. Upon blocking a shot, it has a chance of triggering The Necronomicon effect.
E Coli	236		Turdy touch	Gives "Turdy Touch" Effect. Enemies that touch Isaac are changed into poop.
Epic Fetus	168		On-demand air strike	Isaac's tears are replaced with guided missiles, like those used by the Doctor's Remote.
Epiphora	368		Intensifying tears	Shooting in one direction increases Isaac's rate of fire until the cap is reached. As soon as Isaac changes direction or stops shooting, rate of fire is reset to its normal amount.
Eve's Mascara	310		Shot speed down + DMG up	Doubles damage, halves tears stat, and greatly reduces shot speed.
Evil Eye	410		Eye shot!	While firing tears, Isaac has a chance to fire an eye across the screen with a very slow shot speed, which will fire tears of its own in the same direction as Isaac. The eye will be destroyed if it comes into contact with an enemy or obstacle.
Explosivo	401		Sticky bomb shot!	Isaac's tears have a chance to stick to enemies and explode.
Fire Mind	257		Flaming tears	Grants flaming tears that deal burning damage over time. Tears have a chance to explode on impact with an enemy, which creates a fire at the location of the explosion.
Forever Alone	128		Attack fly	Spawns a blue attack fly that orbits a long distance from Isaac.
Friend Zone	364		Friendly fly	A white orbiting fly which deals 3 contact damage per tick to enemies. This familiar orbits Isaac at a middle length distance somewhere between Distant Admiration and Forever Alone.
Gemini	318		Conjoined friend	Suture becomes attached to Isaac, and does touch damage to enemies within its attacking range.
Ghost Baby	163		Spectral buddy	Spawns a familiar that follows Isaac around and fires spectral tears.
Glitter Bombs	432		Prize bombs!	Gives Isaac 5 bombs, and makes Isaac's bombs have a chance to drop random pickups or charm enemies when they explode.
Gnawed Leaf	210		Unbreakable	After standing still and not shooting for a short time, Isaac turns invincible until he moves or shoots.
God's Flesh	398		Shrink shot	Tears now have a random chance to apply a shrinking effect, causing enemies to shrink in size and also run away from Isaac. Shrunk enemies can be crushed and killed by walking over them.
Godhead	331		God tears	Increases damage and range while reducing tears and shot speed. Grants homing tears and tears gain a damaging halo.
Guillotine	206		An out-of-body experience	Isaac's head is removed from his body and floats around him. Increases Damage by 1 and grants -1 Tear Delay.
The Halo	101		All stats up	Grants one Heart Container, +0.3 Damage, +0.2 Tears, +0.25 Range, +0.3 Speed, and +0.5 Tear Height.
Halo of Flies	10		Projectile protection	Spawns two pretty fly familiars that block enemy shots and deal contact damage to enemies.
Harlequin Baby	167		Double shot buddy	Spawns a familiar that follows Isaac around and fires two tears at once in a V-pattern.
Headless Baby	269		Bloody Friend	Familiar that follows Isaac, leaving blood creep on the ground.
Holy Light	374		Holy shot!	Isaac has a random chance to fire a Holy tear, which, when it hits an enemy, will spawn a Crack the Sky-style light beam on the same enemy, dealing damage.
Host Hat	375		Nice hat!	A host familiar that sits on Isaac's head and has a random chance to block enemy shots and retaliate with 3 tears. Grants immunity to explosions.
Hot Bombs	256		Burning blast +5 bombs	Grants 5 bombs. Isaac's bombs leave behind fire that damages enemies upon contact.
Infamy	242		Damage Reduction	Chance to block projectiles coming from any direction.
Infestation	148		They grow inside	1-3 Blue flies randomly spawn every time Isaac gets hit.
Infestation 2	234		Infestation shot	Spawns allied blue spiders from killed enemies.
The Inner Eye	2		Triple shot	Grants triple shot but decreases tears.
Ipecac	149		Explosive shots	Replaces tears with explosive and poisoning projectiles fired in an arc from the mouth.
Iron Bar	201		Concussive tears	Increases damage by 0.3 and adds a chance to shoot concussive tears, causing enemies to walk around randomly.
Judas' Shadow	311		Sweet revenge	Adds an extra life; upon death, it respawns Isaac as Black Judas with only two black hearts.
Juicy Sack	266		Sticky babies	A familiar that follows behind Isaac. It drips a trail of creep, which slows enemies, and spawns 1-2 blue spiders after each room.
Kidney Stone	440		Matt's kidney stone	Randomly while firing tears, Isaac will stop firing and turn red, where he will charge and release a lot of 'tears' in one go. In the burst of tears is a kidney stone which deals a lot of damage.
Lazarus' Rags	332		Eternal Life?	Upon dying, resurrect as Revived Lazarus with one heart container and Anemic item.
Leo	302		Stompy	Allows you to crush rocks when you walk over them.
Lil Gurdy	384		A gurd of your own!	Gives Isaac a Gurdy familiar that will charge around the room dealing contact damage to enemies. Lil Gurdy is charged by holding down a fire button and letting go. The longer the button is held, the faster Lil Gurdy will fling itself across the screen. Lil Gurdy can pass over objects and obstacles in the room.
Lil Haunt	277		Fear him	A familiar that damages enemies by chasing them as well as inducing the fear effect.
Little C.H.A.D.	96		Gives kisses	A familiar who will drop a half red heart every 2 rooms.
Little Chubby	88		Attack Buddy	A familiar that charges forward and deals touch damage to any enemies in its path.
Little Gish	99		Sticky friend	Spawns a familiar that follows Isaac around and fires slowing tears, impeding enemies' speed.
Little Steven	100		Psychic friend	Spawns a familiar that follows Isaac around and fires homing tears.
Loki's Horns	87		Cross Tears	Gives a random chance for projectiles to fire in all 4 cardinal directions.
Lost Contact	213		Shielded tears	Every tear has a small shield which will allow it to block one enemy projectile.
Lost Fly	365		Lost protector	A familiar fly that moves in a straight line and attaches itself to the first obstacle or wall it comes into contact with in each room. If any enemies walk into its path, it will deal 7 contact damage per tick. If the obstacle it is attached to is destroyed then it will continue rolling in the direction it was previously travelling until it meets another wall or obstacle.
The Ludovico Technique	329		Controlled Tears	Instead of firing tears, Isaac controls one floating tear that hover over obstacles. This tear deals constant damage when held in place over an enemy.
Lusty Blood	411		Their blood brings rage!	Each time Isaac kills an enemy, Isaac's damage increases for the current room.
Maggy's Bow	312		HP up + you feel healthy	Gives one heart container and doubles the healing provided by red hearts.
Magic Mushroom	12		All Stats Up!	Increases all stats and enlargens Isaac.
Marked	394		Directed tears	Isaac will now fire tears automatically directed at a red target on the ground which is controlled by the player. This allows for a full 360 degree tear firing radius. Can be overridden by other tear modifiers such as Mom's Knife or Brimstone.
Milk!	436		Don't cry over it...	A glass of milk follows Isaac and spills on the floor upon taking damage. After the milk spills, Isaac's tear delay is decreased by 2 for the rest of the room.
The Mind	333		I know all	Grants the combined effects of the Blue Map, Treasure Map, and The Compass, revealing the floor layout and all special rooms, including Secret Rooms and Super Secret Rooms.
Missing No.	258		Syntax error	Randomizes all passive items upon pickup and at the start of each succeeding floor.
Mom's Contacts	110		Freeze effect	Adds a chance to shoot petrifying tears, which stop enemies in place and prevent them from moving or attacking. Range up.
Mom's Eyeshadow	200		Charm tears	Tears have a chance to charm enemies.
Mom's Eye	55		Eye in the back of your head	Allows Isaac to fire tears from the back of his head.
Mom's Knife	114		Stab stab stab	Isaac's tears are replaced by a knife that pierces enemies, can travel through obstacles, and can hurt enemies while Isaac is holding it. Holding down the fire button before firing increases its range and power.
Mom's Perfume	228		Fear shot	Adds a chance to shoot fear tears and decreases tear delay by 1.
Mom's Wig	217		You feel itchy...	Adds a chance to spawn blue spiders when firing tears. Restores 1 red heart.
Mongo Baby	322		Mongo Friend	Summons a familiar that copies the tears of Isaac's other familiars.
Monstro's Lung	229		Charged attack	Increases damage and grants a charged shot that fires multiple tears in the same fashion as Monstro.
Mr. Mega	106		Blast damage	Gives Isaac 5 bombs, and makes all dropped bombs larger, which have an increased blast radius and increased damage.
The Mulligan	151		They grow inside	Tears have a 1/6 chance of spawning allied blue flies when they hit an enemy.
Multidimensional Baby	431		ydduB Buddy	Spawns a familiar that will follow Isaac's movements on a 2.5 second delay. Tears that pass through the baby will be doubled and increase in speed.
Mutant Spider	153		Quad shot	Grants quadruple shot but decreases tears.
My Reflection	5		Boomerang tears	Gives Isaac's tears a boomerang effect, and increases range and shot speed.
Mysterious Liquid	317		Toxic Splash Damage	Tears leave a small, short lasting pool of creep on impact or when their range is depleted.
Mystery Sack	271		?	Spawns a familiar that follows Isaac around and has a chance to drop a heart, coin, bomb, or key after clearing a room.
Night Light	425		Scared of the dark?	A cone of light shines in the direction Isaac is moving that slows enemies and enemy shots.
No. 2	378		Uh oh...	Continuously firing tears for several seconds causes Isaac to drop a Butt Bomb. Butt Bombs explode for 50 damage like normal bombs, but also deal 10 damage to all enemies in the room and daze them for a short period of time.
Number One	6		Tears up	+1.5 tears, -17.62 range
Obsessed Fan	426		Follows my every move...	A purple fly familiar that follows Isaac's movements on a 3 second delay and deals contact damage to enemies.
Odd Mushroom	121		DMG up	Grants an empty heart container. Increases damage, range and shot height while reducing speed.
Odd Mushroom	120		Fire rate up	+1.7 tears, +0.3 speed, reduces damage.
Ouija Board	115		Spectral tears	Grants spectral tears that travel through obstacles (but not enemies) instead of breaking on impact with them.
Papa Fly	430		Turret follower	A blue fly familiar follows Isaac's movements on a 3 second delay. Papa Fly will fire tears at nearby enemies.
The Parasite	104		Split Shot	Isaac's tears split in two when they hit something.
Pay to Play	380		Money talks	This item turns all doors that require a key into doors which need a coin to enter instead. This affects shops, item rooms, libraries and other key doors.
The Peeper	155		Plop!	Spawns a familiar that floats slowly around the room on a zig-zag pattern similar to Boom Flies damaging enemies it passes through.
Pisces	309		Tears up + knock-back shots	-1 Tear Delay, adds knock-back shots and increases tear size.
Polyphemus	169		Mega Tears	Makes Isaac shoot one huge tear. Also reduces Tears to minimum. Damage increased . If tear does more damage than an enemy's life, the tear continues to travel with the extra remaining damage.
Proptosis	261		Short range mega tears	Tears start out massive with high damage, and then shrink down and become weaker over a short range.
Punching Bag	281		Scape Goat	Spawns a Mulligan Familiar that will wander the room randomly. Enemies will attack the Mulligan if it's closer.
Pupula Duplex	379		Wide shot	Transforms Isaac's tears into a wide arc shape which gives them a much larger hitbox. Gives Isaac spectral tears which allows them to travel through objects in the environment (i.e. rocks).
Purity	407		Aura stat boost	This item will boost one of Isaac's stats depending on the color of the aura around him. The aura will disappear upon taking damage and will reappear with a random color upon entering a new room. A red aura boosts damage, a blue aura boosts rate of fire, a yellow aura boosts speed, and an orange aura boosts range.
Pyromaniac	223		It hurts so good +5 Bombs	Isaac heals 1 heart instead of taking damage from an explosive source. Adds 5 bombs.
Pyro	190		99 bombs	Adds 99 bombs.
Rainbow Baby	174		Random buddy	Spawns a familiar that follows Isaac around and fires tears with random effects.
The Relic	98		Soul generator	Isaac is followed by a small blue cross that will drop a Soul Heart every 4 rooms.
Robo-Baby	95		Friends 'till the bbbbzzzt	Follows Isaac around, shooting enemies with an eye laser similar to Technology.
Robo-Baby 2.0	267		We worked out all the kinks	Fires lasers at any enemy in its line of sight and moves based on the direction Isaac is firing tears.
Rotten Baby	268		Infested friend	A familiar that spawns blue flies.
Rubber Cement	221		Bouncing tears	Tears bounce off walls, enemies, and environmental objects.
Rune Bag	389		Rune generator	A bag that follows Isaac and drops a random rune every 3 rooms.
Sack of Pennies	94		Gives money	Isaac is followed by a small bag that drops a coin every 2 rooms.
Sacrificial Dagger	172		My fate protects me	Dagger orbits Isaac, dealing very high damage.
Sad Bombs	220		Tear blast +5 bombs	+5 Bombs. Upon exploding, bombs shoot 8 tears off in every direction, similar to Tammy's Head. The tears are affected by any tear modifiers Isaac has on his own tears.
The Sad Onion	1		Tears up	Increases Tears by 0.7.
Sagittarius	306		Penetrative shot + speed up	Increases speed by +0.2 and grants piercing tears.
Samson's Chains	321		The ol' ball and chain	Pull a chain and ball behind you that will damage enemies on contact and is able to break stones.
Scapular	142		You have been blessed	Once per room, when Isaac is reduced to his last half red Heart, the aura around his head temporarily vanishes and he is granted one Soul Heart.
Scatter Bombs	366		We put bombs in your bombs!	Adds 5 bombs. Isaac's bombs explode into 2-4 tiny bombs.
Scorpio	305		Poison tears	Grants poison tears, which deal damage over time when inflicted.
Serpent's Kiss	393		The kiss of death	Tears now have a random chance to apply a poison effect, causing 4 or 6 damage per tick to enemies (Similar to The Common Cold item). Isaac now deals poison damage on contact with enemies similar to The Virus item (Damage over time 4 or 6 per tick). Enemies that were poisoned have a chance to drop a black heart when killed.
Sissy Longlegs	280		She loves you	Wanders about the room, occasionally spawning blue spiders.
Sister Maggy	67		Friends 'till the end	A familiar that follows Isaac around shooting blood tears.
Smart Fly	264		Revenge fly	After Isaac takes damage, this fly will deal continuous touch damage to whatever enemy caused the damage until it is dead. The fly will then systematically attack 1 enemy at a time until the room is cleared.
The Soul	335		I am all	Grants two soul hearts. Isaac now repels enemy projectiles.
Soy Milk	330		DMG Down + Tears Way Up	Tears shrink and do much less damage, but fire in very rapid succession.
Spider Bite	89		Slow effect	Adds a chance to shoot slowing tears, reducing speed of enemy movement and any projectile fired by them.
Spoon Bender	3		Homing shots	Grants Isaac homing tears.
Steam Sale	64		50% off	Reduces all Shop prices by 50%, rounded down to 7 coins for an item, rounded up to 2-3 coins for a pickup.
Steven	50		DMG up	Increases Damage by 1.
Sticky Bombs	367		Egg sack bombs!	+5 bombs. Bombs stick to enemies and spawn 2-4 blue spiders if they kill an enemy.
Stigmata	138		DMG + HP up	Increases damage, and adds 1 heart container.
Strange Attractor	315		Magnetic tears	Pickups, trinkets, and monsters are magnetically attracted to Isaac's tears.
Taurus	299		Speed down + rage is building	Speed down; gains speed while in a room with enemies until gaining My Little Unicorn effect for a few seconds.
Tech X	395		Laser ring tears	Tears are replaced with laser rings that pierce through enemies and deal damage to enemies within them. Can be charged to increase the size of the ring.
Tech.5	244		It's still being tested...	Grants a unlimited range piercing laser with random rate of fire that does not replace tears. The laser might occasionally fire with the effect of a random item or trinket, such as Hook Worm, Spoon Bender or Tiny Planet.
Technology	68		Laser tears	Replaces tears with a piercing laser with unlimited range.
Technology 2	152		Laser	Decreases damage and replaces right eye tears with a unlimited range, piercing laser which fires continuously.
Tiny Planet	233		Orbiting tears + range up	Range up and makes shot tears revolve around Isaac until they drop.
Tough Love	150		Tooth shot	Adds a chance to shoot a tooth instead of a tear, which deals greater damage than regular tears.
Tractor Beam	397		Control your tears	Isaac emits a beam from his face. Isaac's tears travel in the path of the beam.
Virgo	303		You feel refreshed and protected	Grants a chance to trigger the Book of Shadows effect upon taking damage, creating a shield that nullifies all types of damage for 10 seconds. Also converts "bad pills" into "good pills".
The Virus	13		Poison touch	Inflicts poison to enemies who make contact with Isaac. Speed down.
The Wafer	108		Damage resistance	All sources of damage that would cause more than one half heart of damage are reduced to one half heart instead.
The Wiz	358		Double wiz shot!	Tears simultaneously fire out of both eyes diagonally, similar to the effect of the R U A Wizard? pill. Isaac's tears also travel above all obstacles.
Zodiac	392		The heavens will change you	Zodiac will give Isaac a random zodiac item effect that changes after every floor.