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Universal (Bosses)

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Bosses
Chapter 1 Chapter 2 Chapter 3 Chapter 4 Added in Afterbirth ??? Chapter 5 Chapter 6 Added in Afterbirth † The Void
Universal Devil and Angel Room Seven Deadly Sins Added in Afterbirth Greed Mode All Mini-Bosses All Bosses

Universal[edit | edit source]

Universal Bosses are those which may appear at the end of floors 1-5 and 7, replacing a boss from the pool for that environment.

Boss The Fallen.png
Boss The Headless Horseman.png
The Fallen Requires previous entry into a devil room The Headless Horseman Needs to be unlocked


Bosses Boss Monstro.png
Chapter 1
Stage The Basement icon.pngStage The Cellar icon.pngStage Burning Basement icon.png
GeminiStevenBlighted OvumDingleThe Duke of FliesFamineFistulaGurglingsThe HauntLarry Jr.MonstroPinWidowThe FallenThe Headless Horseman
DangleLittle HornRag ManTurdlings
Chapter 2
Stage The Caves icon.pngStage The Catacombs icon.pngStage Flooded Caves icon.png
ChubC.H.A.D.Carrion QueenDark OneGurdyGurdy Jr.The HollowThe HuskMega FattyMega MawPeepPestilencePolycephalusThe WretchedThe FallenThe Headless Horseman
The ForsakenThe FrailThe Stain
Big HornRag Mega
Chapter 3
Stage The Depths icon.pngStage Necropolis icon.pngStage Dank Depths icon.png
The AdversaryThe BloatThe CageThe GateMonstro IIGishLokiMask of InfamyWarThe FallenThe Headless HorsemanMom
Brownie
Sisters Vis
Chapter 4
Stage The Womb icon.pngStage Utero icon.pngStage Scarred Womb icon.png
BlastocystThe BloatConquestDaddy Long LegsTriachnidDeathLokiiMama GurdyMr. FredScolexTeratomaThe FallenThe Headless HorsemanMom's HeartIt Lives
Sisters VisThe Matriarch
Blue Womb
???
Hush
Chapter 5
Stage Sheol icon.pngStage Cathedral icon.png
SatanIsaac
Chapter 6
Stage Dark Room icon.pngStage The Chest icon.png
???The LambMega Satan
The Void
Stage The Void icon.png
Delirium
Greed Mode
Ultra Greed
Ultra Greed
Ultra Greedier
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