Modified room #717 on the Basement/Cellar so that Mulligans no longer spawn next to the entrances. (Mulligans have a chance to randomly explode upon room loading. If this occurred before the patch, it was guaranteed damage to the player.)
Removed the top entrances from Devil room #11 and #14. (These are the rooms with Nulls and an Imp, which also happen to spawn at the top of the room, which causes near-guaranteed damage to the player.)
Technology, Technology 2, and Tech.5 function as if the player has spectral tears. (Visually, the items will appear to be functioning normally, but this isn't the case.)
If you pick up Tech X after picking up Ipecac, you still erroneously retain the +40 damage boost from Ipecac and the increased tear delay. After the damage stat is refreshed (by picking up another damage item), this bug goes away.
With a controller attached, it is possible to move Isaac when the game is out of focus and get him across loading zones and spikes without taking any damage.[1]