When Life Gives You Lemons

Isaac

9 VoltReduces the charge of any Activated Items by 1. Any 1 charge items instead have timed recharges. HabitWhen Isaac is hit, 1 point of an item's charge is filled. Lemon MishapCreates a small yellow pool of creep, which damages enemies that cross it. 1 Lemon Party pill

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Card Against HumanityComplete challenge #12

When Life Gives You Lemons is Challenge #12. Start off with Lemon MishapCreates a small yellow pool of creep, which damages enemies that cross it., 9 VoltReduces the charge of any Activated Items by 1. Any 1 charge items instead have timed recharges., HabitWhen Isaac is hit, 1 point of an item's charge is filled. and 1 Lemon Party pill. The goal is to defeat Mom. This Challenge is available by default. Treasure rooms are not present.

Difficulty

The lack of Treasure Rooms makes the challenge more difficult than a normal run.

Strategy

• Lemon Mishap has a small range, making it difficult to use. The Habit and 9 Volt will allow more frequent uses of it but their combination is more important than that. Because every run starts with 9 Volt, any activated item obtained will take less time to recharge. The Habit makes taking damage charge it faster as well. The only catch would be finding a better activated collectible.
• The Lost CorkIncreases the radius of any creep produced by Isaac. is an extremely beneficial trinket in this run, expanding the area of Lemon Mishap and thus making it safer to use since Isaac doesn't need to be as close to the enemy.
• A good item to find is Shoop Da Whoop!Fires a laser from Isaac's mouth., which is usable every room because of 9 Volt.

Reward

• 

  Card Against Humanity - Complete challenge #12.

Trivia

• The challenge name is a reference to the proverbial phrase "When life gives you lemons, make lemonade."
• One of the fortune teller's fortunes is "When life gives you lemons, reroll!"