Wrath is a mini-boss and one of the Seven Deadly Sins. He is a figure with pale skin, black eyes, and a gray suit.
- Wanders around the room randomly, usually towards Isaac.
- Fires live bombs at Isaac.
- Occasionally, 2 regular Wraths will appear in a miniboss room and the boss message will display "Isaac vs Super Wrath".
- Wrath takes only 20 damage (as opposed to the usual 60) from his own bombs. Isaac's bombs and Epic Fetus missiles deal 200 damage regardless of modifiers or damage stat.
- The way Wrath attacks, his room's layout (most of the time), and his appearance are references to the classic Bomberman series of games.
- The item Mr. Mega will make Isaac's head appear the same as Wrath's.