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Font TeamMeat Z.pngFont TeamMeat o.pngFont TeamMeat d.pngFont TeamMeat i.pngFont TeamMeat a.pngFont TeamMeat c.png
Item icon
Item altar
Table dividing line 1.png


Character appearance
Table dividing line 2.png
Table dividing line 3.png

Added in Afterbirth †(page 4, column 7, row 2)
Removed in Afterbirth †(page 4, column 7, row 2)

Zodiac Defeat Ultra Greed as The Lost
Added in Afterbirth

For a list of all zodiac signs, see Signs of the Zodiac.

Zodiac is an unlockable passive item added in the Binding of Isaac: Afterbirth expansion.

Effects[edit | edit source]

  • Gives Isaac a random Zodiac item effect that changes each floor.

Notes[edit | edit source]

  • Getting Capricorn Capricorn, Cancer Cancer and Libra Libra does not grant coins, bombs, keys or soul hearts. Leo Leo will not change Isaac's size.
  • If already in possession of the item given by Zodiac, most have no effect. The only exceptions are Capricorn Capricorn giving an additional +0.5 damage, and Gemini Gemini giving another familiar.

In-game Footage[edit | edit source]

Trivia[edit | edit source]

  • This item's icon may be a reference to the Zodiac Killer, a serial killer that used the same symbol.
  • This item's icon shares the same icon as Marked Marked but white instead of red.

Seeds[edit | edit source]

 PC  ZXMH RH2C (Treasure room adjacent to spawn) (Both modes)

The Lost Unlocks The Lost Unlocks The Lost Unlocks
Isaac's HeartThe MindThe BodyThe SoulThe D100Godhead-0- Baby Sworn ProtectorZodiacWhite Baby Holy CardDad's Lost Coin
The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth
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