Binding of Isaac: Rebirth Wiki
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There are two types of Challenge Rooms. They will only spawn on a floor if, upon entering the floor, Isaac's total health is greater than or equal to his number of heart containers.

Normal Challenge Room

Challenge Room

Can only be entered if Isaac's total health (red, black, and soul hearts) is greater than or equal to his number of heart containers.

Picking up its contents will spawns 3 waves of enemies when opened. While in Chapter 4 (Womb/Utero), 3 waves of bosses will be spawned (usually bosses from Basement/Caves).

(in Afterbirth † and Repentance) Each wave cleared will charge Isaac's active item by 1.

A Challenge Room can contain:

The enemies that spawn depend on the current chapter, and each chapter has two different possible sets of enemies:

Floor Wave 1 Wave 2 Wave 3
The Basement 3 Hoppers 3 Horfs 2 Clotties
5 Attack Flies 5 Pooters 4 Gapers
The Cellar 3 Fattys 3 Round Worms 5 Dips
3 Gapers 3 Horfs 3 Fatties
The Caves 5 Chargers 4 Globins 4 Maws
5 Spitties 3 Hives 3 Hosts
The Catacombs 2 Bonies 2 Tumors 3 Wall Creeps
4 Round Worms 3 Nightcrawlers 1 Grub
The Depths 3 Vis 4 Leapers 4 Globins
4 Babies 5 Hoppers 4 Knights
Necropolis 4 Knights 3 Mom's Hands 3 Fat Sacks
4 Bonies 2 Squirts 3 Nulls
The Womb
Cathedral
Utero
Sheol
3 Larry Jrs Chub and 3 Chargers 2 Monstros
Fistula Loki Chub

Notes

  • (except in Rebirth) The three waves appear in random orders rather than the orders listed above.
  • If Isaac has some way to teleport out of the room, the contents of the Challenge Room can be taken without fighting the enemies.
  • If a Secret Room is next to a Challenge Room, it can be entered by using a bomb in the Secret Room on the wall separating the two rooms. However, the entrance to the Secret Room from the Challenge Room closes itself, meaning Isaac cannot escape through the Secret Room entrance.
  • If Spiders had spawned from the red chest before the enemy waves had started, the spiders have to be killed in order for the waves to start.
    • If Spiders had spawned from the Red Chest after the enemy waves are over, the player may choose to leave the room without having to fight them.

Boss Challenge Room

Boss Challenge Room Door

Boss Challenge Rooms can only be entered if Isaac has one or less red heart. Its contents are similar to the normal Challenge Room, but there is a chance it will contain an item from the Boss Item Pool.

After opening a chest or taking a pedestal item inside the room, a boss will spawn. After beating the first boss, a second will spawn.

(in Afterbirth † and Repentance) Each wave cleared will charge Isaac's active item by 1.

The bosses that spawn depend on the current chapter. Alternate floors have two possible sets of bosses that could spawn:

Floor Wave 1 Wave 2
The Basement Monstro Larry Jr.
The Cellar Pin Gurglings
Dingle Gemini
The Caves Chub Peep
The Catacombs Mega Fatty Mega Maw
Fistula The Haunt
The Depths Loki Monstro II
Necropolis Mega Maw The Husk
Dark One Loki

Notes

  • In Chapter 4 and beyond, the bosses spawned in the Boss Challenge Room are the same as those spawned in the standard Challenge Room.
  • If a Secret Room is next to a Boss Challenge Room, it can be entered by using a bomb in the Secret Room on the wall separating the two rooms. However, the entrance to the Secret Room from the Boss Challenge Room closes itself, meaning Isaac cannot escape through the Secret Room entrance.
  • Because of the health requirements, both types of Challenge Room will always be open for The Lost and Blue Baby.
  • Like the Challenge Room, Spiders have to be killed if they come out of Red Chests before the boss waves start.

Bugs

Bug Bug! (in Rebirth and Afterbirth) If the game crashes or you close it before you finish the challenge room it will crash every time you try to continue that run.


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