Challenges

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Challenges are unique runs in the game. Challenges typically start the player off with one or more specific items which make normal play more difficult. You will not find Treasure Rooms (with the exception of a select few challenges). Completing one of the thirty five challenges unlocks new content for the game, such as Runes.

General Strategy[edit | edit source]

Most challenges are geared to make a run difficult in some form. Sometimes, these challenges are easy, like Computer Savvy. Other times, they can be vicious, like Solar System. Each challenge has a certain strategy that can make the run easier. However, there are a few strategies that can apply to all challenges.

  • You can play in co-op for every challenge, making it easier for the ones where you cannot fire tears - especially for Cat Got Your Tongue, since it will spawn flies.
  • Because of the lack of Treasure Rooms, Devil Rooms become much more valuable. Some challenges can be made much easier by making just one deal.
  • You can also be more liberal with your use of keys for the same reason. Trinkets and Items that generate more coins, along with upgraded shops, can help reduce the difficulty in many challenge runs.
  • The Bible The Bible can make the end of some runs extremely easy. Because of how some challenges operate, the run may only require defeating Mom or Mom's Heart / It Lives. Since The Bible The Bible is a one-hit kill against these, getting it when you have the chance is usually a good investment for these runs.
  • Curse Rooms gain value since they can spawn items. You may wish to restart on the first floor until your Curse Room spawns an item worth 1 heart of damage.
  • Dice Rooms and the D4 D4 are very useful, as in some cases you can reroll your entire build and remove (or add) difficulty.
    • DLC Indicator.png Dice rooms do not re-roll starter challenge items or remove Blindfolded.
    • Afterbirth† Indicator.png Butter! Butter! can remove starter items.
  • In Blindfolded challenges, familiars can make the run easier, as they are your only source of conventional damage. Powerful familiars like Daddy Longlegs Daddy Longlegs , Lil Brimstone Lil Brimstone , and DLC Indicator.png Incubus Incubus are very good items to pick up. Some of the strongest familiars need to be unlocked first, so it may be wise to take the time to unlock them beforehand.
    • The Boomerang The Boomerang , The Candle The Candle , and Red Candle Red Candle are also useful for blindfolded challenges, since they deal damage and recharge based on a timer.
      • DLC Indicator.png In Blindfolded challenges, if possible finding and using the Afterbirth† Indicator.png Clicker Clicker , change yourself into the character Lilith, will make these challenges incredibly easy with access to tears through her DLC Indicator.png Incubus Incubus you gain.
  • DLC Indicator.png In challenges that remove Treasure Rooms, DLC Indicator.png Chaos Chaos has more potential to be useful by potentially making Treasure Room (among other rare items) items purchasable from the shop. On the downside, it may replace the Devil/Angel Room items with something less valuable.
  • Defeating a boss beyond the specified end of the challenge (e.g. defeating Mom's Heart when the goal is to defeat Mom) will still cause them to drop the trophy.
    • DLC Indicator.png This means a legitimate tactic for some of the longer challenges (e.g. XXXXXXXXL) is to use the Sacrifice Room until it teleports you to the Dark Room, then going through and defeating The Lamb, completing the challenge regardless of what floor you were teleported from.

Notes[edit | edit source]

  • New content, other than the Challenge Reward, cannot be unlocked. Likewise, you will not find a Donation Machine anywhere.
  • The Challenge reward will not be unlocked unless you pick up the trophy, meaning if a Devil Room or Angel Room appears and allows you to go to Sheol or the Cathedral you will be forfeiting the unlock if you fail to complete the floor.
  • Any challenge featuring Isaac will not start with The D6 The D6 .

Challenge list[edit | edit source]

Name Conditions Goal Unlocked by Unlocks
1. Pitch Black
Isaac App.png
HUD Red Heart.pngHUD Red Heart.pngHUD Red Heart.png
Curse of Darkness
Curse of the Unknown
Item Pool Treasure Room.png: yes
Item Pool Shop.png: no
Boss Mom.png Default Rune of Hagalaz Rune of Hagalaz
2. High Brow
Isaac App.png
HUD Red Heart.pngHUD Red Heart.pngHUD Red Heart.png
Starts with:
Number One Number One
E Coli E Coli
Butt Bombs Butt Bombs
Flush! Flush!
Petrified Poop Petrified Poop
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom.png Default Rune of Jera Rune of Jera
3. Head Trauma
Isaac App.png
HUD Red Heart.pngHUD Red Heart.pngHUD Red Heart.png
Starts with:
Tiny Planet Tiny Planet
Soy Milk Soy Milk
The Small Rock The Small Rock
Iron Bar Iron Bar
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom.png Default Rune of Ehwaz Rune of Ehwaz
4. Darkness Falls
Eve App.png
HUD Red Heart.pngHUD Red Heart.png
Starts with:
Pentagram Pentagram
Dead Bird Dead Bird
Whore of Babylon Whore of Babylon
Razor Blade Razor Blade
Sacrificial Dagger Sacrificial Dagger
Dark Matter Dark Matter
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Satan.png Darkness Falls Defeat Mom's Heart 11 times Rune of Dagaz Rune of Dagaz
5. The Tank
Magdalene App.png
HUD Red Heart.pngHUD Red Heart.pngHUD Red Heart.pngHUD Red Heart.png
Starts with:
Infamy Infamy
Bucket of Lard Bucket of Lard
Thunder Thighs Thunder Thighs
Yum Heart Yum Heart
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom.png The Tank Have 7 or more heart containers at one time Rune of Ansuz Rune of Ansuz
6. Solar System
Isaac App.png
HUD Red Heart.pngHUD Red Heart.pngHUD Red Heart.png
Blindfolded App.png Blindfolded
Starts with:
Distant Admiration Distant Admiration
Forever Alone Forever Alone
Halo of Flies Halo of Flies
Transcendence Transcendence
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom's Heart.png / Boss It Lives.png Solar System Defeat Mom's Heart 3 times Rune of Perthro Rune of Perthro
7. Suicide King
Lazarus App.png
HUD Red Heart.pngHUD Red Heart.pngHUD Red Heart.png
Starts with:
Ipecac Ipecac
Mr. Mega Mr. Mega
My Reflection My Reflection
1 random Pill
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Isaac Suicide King 2 Defeat Mom's Heart 11 times Suicide King Suicide King
8. Cat Got Your Tongue
Isaac App.png
HUD Soul Heart.pngHUD Soul Heart.pngHUD Soul Heart.pngHUD Black Heart.pngHUD Black Heart.pngHUD Black Heart.png
Blindfolded App.png Blindfolded
Starts with:
Guppy's Hair Ball Guppy's Hair Ball
Guppy's Head Guppy's Head
Guppy's Tail Guppy's Tail
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom.png Cat Got Your Tongue Become Guppy (Collect 3 Guppy Items) Rune of Algiz Rune of Algiz
9. Demo Man
Isaac App.png
HUD Red Heart.pngHUD Red Heart.pngHUD Red Heart.png
Starts with:
Dr. Fetus Dr. Fetus
Remote Detonator Remote Detonator
Match Stick Match Stick
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom's Heart.png / Boss It Lives.png Demo Man Defeat Mom's Heart 9 times Chaos Card Chaos Card
10. Cursed!
Magdalene App.png
HUD Red Heart.pngHUD Red Heart.pngHUD Red Heart.pngHUD Red Heart.png
Starts with:
Blue Map Blue Map
The Compass The Compass
Raw Liver Raw Liver
Treasure Map Treasure Map
Yum Heart Yum Heart
Child's Heart Child's Heart
Curse of the Cursed
Item Pool Treasure Room.png: yes
Item Pool Shop.png: yes
Boss Mom.png Cursed! Have 7 or more heart containers at one time Credit Card Credit Card
11. Glass Cannon
Judas App.png
HUD Red Heart.png
Starts with:
Epic Fetus Epic Fetus
Loki's Horns Loki's Horns
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Satan.png Glass Cannon Beat challenge #19 and defeat Lokii for the 1st time Rules Card Rules Card
12. When Life Gives You Lemons
Isaac App.png
HUD Red Heart.pngHUD Red Heart.pngHUD Red Heart.png
Starts with:
9 Volt 9 Volt
Habit Habit
Lemon Mishap Lemon Mishap
1 Lemon Party pill
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom.png Default Card Against Humanity Card Against Humanity
13. Beans!
Isaac App.png
HUD Red Heart.pngHUD Red Heart.pngHUD Red Heart.png
Blindfolded App.png Blindfolded
Starts with:
9 Volt 9 Volt
The Bean The Bean
The Black Bean The Black Bean
Butt Bombs Butt Bombs
Pyro Pyro
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom.png Default Burnt Penny Burnt Penny
14. It's in the Cards
Isaac App.png
HUD Red Heart.pngHUD Red Heart.pngHUD Red Heart.png
Starts with:
9 Volt 9 Volt
The Battery The Battery
Deck of Cards Deck of Cards
Starter Deck Starter Deck
2 random tarot cards
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom.png Default SMB Super Fan SMB Super Fan
15. Slow Roll
Isaac App.png
HUD Red Heart.pngHUD Red Heart.pngHUD Red Heart.png
Starts with:
Cupid's Arrow Cupid's Arrow
My Reflection My Reflection
Polyphemus Polyphemus
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom.png Default Swallowed Penny Swallowed Penny
16. Computer Savvy
Isaac App.png
HUD Red Heart.pngHUD Red Heart.pngHUD Red Heart.png
Starts with:
Spoon Bender Spoon Bender
Technology Technology
Technology 2 Technology 2
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom.png Default Robo-Baby 2.0 Robo-Baby 2.0
17. Waka Waka
Isaac App.png
HUD Red Heart.pngHUD Red Heart.pngHUD Red Heart.png
Starts with:
Anti-Gravity Anti-Gravity
Strange Attractor Strange Attractor
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom.png Default Death's Touch Death's Touch
18. The Host
Isaac App.png
HUD Red Heart.pngHUD Red Heart.pngHUD Red Heart.png
Starts with:
The Mulligan The Mulligan
Spider Baby Spider Baby
Tick Tick
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom.png Default Technology .5 Technology .5
19. The Family Man
Isaac App.png
HUD Red Heart.pngHUD Red Heart.pngHUD Red Heart.png
Blindfolded App.png Blindfolded
Starts with:
BFFS! BFFS!
Brother Bobby Brother Bobby
Dad's Key Dad's Key
Rotten Baby Rotten Baby
Sister Maggy Sister Maggy
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Isaac The Family Man Pick up both Key pieces from the Angels in one run Epic Fetus Epic Fetus
20. Purist
Isaac App.png
HUD Red Heart.pngHUD Red Heart.pngHUD Red Heart.png
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom's Heart.png / Boss It Lives.png Purist Defeat Mom for the first time Rune of Berkano Rune of Berkano
DLC Indicator.png
21. XXXXXXXXL
Isaac App.png
HUD Red Heart.pngHUD Red Heart.pngHUD Red Heart.png
Item Pool Treasure Room.png: yes
Item Pool Shop.png: yes
Every floor is the size of an XL Womb floor, but does not combine the floors of each chapter.
Boss Mom's Heart.png / Boss It Lives.png XXXXXXXXL Defeat Mom for the 1st time Gold Heart Gold Heart
DLC Indicator.png
22. SPEED!
Isaac App.png
HUD Red Heart.pngHUD Red Heart.pngHUD Red Heart.png
Item Pool Treasure Room.png: yes
Item Pool Shop.png: yes
Everything is sped up like the Broken Watch effect.
Boss Mom's Heart.png / Boss It Lives.png
within 16 minutes, otherwise under
constant periodic damage every 10 seconds.
SPEED! Defeat Mom for the 1st time Get out of Jail Free Card Get out of Jail Free Card
DLC Indicator.png
23. Blue Bomber
???
HUD Soul Heart.pngHUD Soul Heart.pngHUD Soul Heart.png
Blindfolded App.png Blindfolded
Starts with:
Brother Bobby Brother Bobby
Kamikaze! Kamikaze!
Pyromaniac Pyromaniac
Mr. Mega Mr. Mega
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Satan.png Blue Bomber Destroy 10 tinted rocks and defeat Mom's Heart 11 times Gold Bomb Gold Bomb
DLC Indicator.png
24. PAY TO PLAY
Isaac App.png
HUD Red Heart.pngHUD Red Heart.pngHUD Red Heart.png
Starts with:
Money = Power Money = Power
Sack of Pennies Sack of Pennies
50 coins
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Every door costs 1 cent to enter. Isaac drops money when hit. Isaac dies if you run out of money.
Isaac PAY TO PLAY Defeat Isaac as Cain 2 new pills 2 new pills
DLC Indicator.png
25. Have a Heart
Isaac App.png
HUD Red Heart.pngHUD Empty Red Heart.pngHUD Empty Red Heart.pngHUD Empty Red Heart.pngHUD Empty Red Heart.pngHUD Empty Red Heart.png
HUD Empty Red Heart.pngHUD Empty Red Heart.pngHUD Empty Red Heart.pngHUD Empty Red Heart.pngHUD Empty Red Heart.pngHUD Empty Red Heart.png
Starts with:
Charm of the Vampire Charm of the Vampire
Item Pool Treasure Room.png: yes
Item Pool Shop.png: yes
Pennies drop instead of red hearts. Many items that restore red hearts have no effect.
Boss Mom's Heart.png / Boss It Lives.png Have a Heart Defeat Mom for the 1st time 2 new pills 2 2 new pills 2
DLC Indicator.png
26. I RULE!
Isaac App.png
HUD Red Heart.pngHUD Red Heart.pngHUD Red Heart.png
Starts with:
The Boomerang The Boomerang
Key Piece 1 Key Piece 1
Key Piece 2 Key Piece 2
The Ladder The Ladder
Mom's Knife Mom's Knife
Trinity Shield Trinity Shield
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mega Satan.png I RULE! Defeat ??? or The Lamb for the 1st time Poker Chip Poker Chip
DLC Indicator.png
27. BRAINS!
???
HUD Soul Heart.pngHUD Soul Heart.pngHUD Soul Heart.png
Blindfolded App.png Blindfolded
Starts with:
3 Bob's Brain Bob's Brain
Thunder Thighs Thunder Thighs
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
??? BRAINS! Defeat Isaac 5 times Stud Finder Stud Finder
DLC Indicator.png
28. PRIDE DAY!
Isaac App.png
HUD Red Heart.pngHUD Red Heart.pngHUD Red Heart.png
Starts with:
3 Dollar Bill 3 Dollar Bill
Rainbow Baby Rainbow Baby
Rainbow Worm Rainbow Worm
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Cannot drop or replace Rainbow Worm.
Boss Mom's Heart.png / Boss It Lives.png PRIDE DAY! Defeat Mom for the 1st time D8 D8
DLC Indicator.png
29. Onan's Streak
Judas App.png
HUD Red Heart.png
Starts with:
The Book of Belial The Book of Belial Chocolate Milk Chocolate Milk
Item Pool Treasure Room.png: yes
Item Pool Shop.png: yes
Missing a shot deals damage to Judas.
Isaac Onan's Streak Defeat Satan as Judas Kidney Stone Kidney Stone
DLC Indicator.png
30. The Guardian
Isaac App.png
HUD Red Heart.pngHUD Red Heart.pngHUD Red Heart.png
Blindfolded App.png Blindfolded
Starts with:
Holy Grail Holy Grail
Isaac's Heart Isaac's Heart
Punching Bag Punching Bag
Spear of Destiny Spear of Destiny
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Isaac's Heart will follow the Punching Bag instead of Isaac.
Boss Mom's Heart.png / Boss It Lives.png The Guardian Defeat Mom for the 1st time Blank Rune Blank Rune
Afterbirth† Indicator.png
31. Backasswards
Isaac App.png
HUD Red Heart.pngHUD Red Heart.pngHUD Red Heart.png
Starts with:
8-10 random items
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
All Chapters progress in reverse order, losing 1 item and 1 red heart container each floor you ascend.
The Basement/The Cellar/Burning Basement I Backasswards Defeat ??? or The Lamb for the 1st time Laz Bleeds More! Laz Bleeds More!
Afterbirth† Indicator.png
32. Aprils Fool
Isaac App.png
HUD Red Heart.pngHUD Red Heart.pngHUD Red Heart.png
Item Pool Treasure Room.png: yes
Item Pool Shop.png: yes
The minimap displays the floor's layout accurately, but displays Isaac's position inaccurately.

Pedestal items and pickups are not what they appear to be. Active item, pill, card, and rune effects are randomized upon each use, making them very unreliable or deadly (for example Suicide King). Items with no charge time (i.e. How To Jump, IV Bag, etc) can be used repeatedly for random effects. Trinkets function normally. Every boss is The Bloat. Isaac's health is not what it appears to be. Key and bomb numbers are accurate.

Boss Mom's Heart.png / Boss It Lives.png Aprils fool Defeat Mom for the 1st time Maggy Now Holds a Pill! Maggy Now Holds a Pill!
Afterbirth† Indicator.png
33. Pokey Mans
Isaac App.png
HUD Red Heart.pngHUD Red Heart.pngHUD Red Heart.png
Starts with:
Friendly Ball Friendly Ball
Mom's Eyeshadow Mom's Eyeshadow
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Each use of Friendly Ball causes a random monster to be spawned. Friendly Ball instantly charges once the spawned monster is killed.
Isaac Pokey Mans Defeat Mom's Heart 11 times Charged Key Charged Key
Afterbirth† Indicator.png
34. Ultra Hard
Isaac App.png
HUD Red Heart.pngHUD Red Heart.pngHUD Red Heart.png
Starts with:
Key Piece 1 Key Piece 1
Key Piece 2 Key Piece 2
Curse of the Labyrinth
Curse of the Blind
Curse of the Lost
Curse of the Maze
Item Pool Treasure Room.png: yes
Item Pool Shop.png: yes
All enemies spawn as champions if possible. Boss fights will be double trouble if possible. No heart pickups drop.
Boss Mega Satan.png Ultra Hard Defeat ??? or The Lamb for the first time Samson Feels Healthy! Samson Feels Healthy!
Afterbirth† Indicator.png
35. Pong
Isaac App.png
HUD Red Heart.pngHUD Red Heart.pngHUD Red Heart.png
Starts with:
Cupid's Arrow Cupid's Arrow
Rubber Cement Rubber Cement
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Damage fixed at 100, tear delay fixed at 150.
??? PONG Defeat Isaac 5 times Greed's Gullet Greed's Gullet


SmallIsaac.png The Binding of Isaac: Rebirth SmallIsaac.png

MainPageAchievements.png Achievements MainPageAttributes.png Attributes MainPageBosses.png Bosses TarotCard.png Cards and Runes MainPageChallenges.png Challenges MainPageChapters.png Chapters
Isaac App.png Characters MainPageBabies.png Co-op Magic Mushroom Icon.png Items Isaac's Tears Icon.png Item Pools MainPageMonsters.png Monsters MainPageObjects.png Objects
Red heart.png Pickups BlueBlue.png Pills MainPageRooms.png Rooms MainPageSeeds2.png Seeds Guppy App.png Transformations The Left Hand Icon.png Trinkets