Guppy's Head is an activated item.
Effects
- Spawns 2-4 friendly blue flies.
- Template:Transf
Notes
- Each blue fly deals double Isaac's damage.
Box of Spiders is essentially the spider equivalent to Guppy's Head, but can be activated less often.
Synergies
- Hive Mind: Increases size and damage of blue flies.
- Ipecac, Polyphemus, and other high-Damage items: Significantly increases the damage dealt by blue flies.
In-game Footage
Trivia
- This item is used in Challenge #8 (Cat Got Your Tongue).
Gallery
3DS The icon of Guppy's Head as seen on the lower 3DS screen
Seeds
PC TK1W XHLH (first curse room)
PS4 J304 8T8Y (first curse room)
 Pet Items
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| Cricket |
| Guppy |
| Tammy |
 The Binding of Isaac: Rebirth
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