Heart may refer to:
Challenges[ | ]
- Have a Heart, challenge #24.
Enemies[ | ]
- Mask + Heart, a monster commonly found in
Necropolis. - Mom's Heart, the final boss of chapter 4.
Items[ | ]
<3, a passive collectible that increases health.
Candy Heart, a passive collectible that grants a stat boost every time red health is regenerated.- BFFS!, a passive collectible that grants increased damage for some familiars.
- Empty Heart, a passive collectible that adds an empty heart container when Isaac has 1 or less red hearts.
- Immaculate Heart, a passive collectible that grants a red heart container, a 1.2 damage multiplier, and a chance to occasionally fire extra spectral tears that orbit around Isaac.
- Isaac's Heart, a passive collectible that grants Isaac direct damage immunity, but allows indirect damage through a following heart familiar.
- Sacred Heart, a passive collectible that grants homing tears, increased damage, increased range, decreased shot speed, and decreased tears.
- Yuck Heart, an activated collectible that grants 1 Rotten Heart.
- Yum Heart, an activated collectible that heals Isaac for 1 Red Heart.
Pickups[ | ]
- Hearts, a type of pickup that comes in Red, Soul, Black, Eternal, Blended, Gold, Bone, Rotten, and Scared variants.
Blended, 
Gold, Trinkets[ | ]
- Child's Heart, which grants an increased chance to find hearts from room drops and chests.
- Purple Heart, which grants an increased chance to find Boss Challenge Rooms and champion enemies.
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 The Binding of Isaac: Rebirth
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