Items are an integral part of game-play in The Binding of Isaac: Rebirth. They modify Isaac's attributes, grant or modify tear effects, and much more.
Items are classified into a number of distinct types and groups. Some items are passive, which add an effect permanently to Isaac, while others only activate when used. The original Binding of Isaac had 196 items. Rebirth has a total of 341 items. 
Afterbirth added 95 new items, for a total of 436 items. 
Afterbirth † added 111 new items, for a total of 547 items. Only 13 items are considered special.
Similar to items are cards and runes, pills, and trinkets.
For a list of which items can potentially appear in a given Special Room, see Item Pool.
For the grids of items that appear in the stats menu, see Collection Page.
Activated Collectibles
Passive Collectibles
Trivia
Wiggle Worm was originally an item in the original Binding of Isaac, however in Rebirth it was changed into a trinket.
The Polaroid was a trinket in the original Binding of Isaac, but it was changed into an item. Interestingly, these changes keep the count of items and trinkets from the original game the same.
- Afterbirth+'s original item count was 89. The Booster Packs added 42 items.
 The Binding of Isaac: Rebirth
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