List of curated daily challenges

Date	Event, if any	Peculiarities
January 1st	New Years	Bomb pool, starting with Pyro, no tears
January 14th		Starting as Guppy, no item rooms
January 16th	National Nothing Day	No item rooms, no shops
January 27th		No item rooms, no shops, Poop pool
February 2nd	Groundhog day	Same seed as the day before
February 9th	National Toothache Day	51 luck, Tooth items, no item rooms
February 11th	National "Don't Cry Over Spilled Milk" Day	Starting with Soy Milk and Milk!
February 14th	Valentine's day	High luck, Mom's items
February 18th	National Battery Day	Starting with battery-related items
March 2nd	Edmund's birthday	Isaac to Mega Satan, Undroppable The Left Hand
March 4th	Holy Experiment Day	Maggie to Mom. No Item Rooms, starting with Immaculate Conception, Eucharist and Seraphim
March 17th	St. Patrick's day	Cain to Mega Satan via The Chest, starts with high luck
March 20th	National Alien Abduction Day	Isaac, starts with Cone Head, The Parasite and Tractor Beam. No item rooms.
March 22nd	National "Goof off" day	Isaac, starts with extreme range; tears follow random patterns
Easter	Easter	Lazarus, Blood of the Martyr, Stigmata, no item rooms
April 1st	April fools	Old Keeper, random trinkets and items upon pickups
April 10th	National siblings day	Lilith, starts with Mongo Baby, Little Steven, Little Gish, Ghost Baby, Brother Bobby and Sister Maggy
April 15th		Lazarus, starts with Tick, Bob's Brain, Dead Cat, Curse of the Tower and Cursed Eye; no item rooms
April 22nd	National Jelly Bean day	Maggie to Sheol, starts with Wait What?, Linger Bean, The Black Bean and 9 Volt; no item rooms
May 4th	May the 4th be with you!	Isaac to The Womb, starts with Technology and the Spear of Destiny
May 8th	Mothers' day	Isaac, Mom transformation, no item rooms
May 13th	National "Stamp Out Hunger" and Frog Jump day	Maggie, starts with Thunder Thighs and How to Jump. No item rooms
May 17th	National "Pack Rat Day"	Isaac, starts with Sack Head and D20
May 30th	Memorial day	The Lost, no tears, 3 familiars and Conjoined
June 2nd		Maggie, starting with Blank Card and High Priestess, no item rooms
June 5th		???, starting Restock and Gnawed Leaf
June 18th	Fathers' day	Cain, A Dollar
June 19th	Fathers' day	Cain, Daddy Longlegs, Dad's Key
June 25th	Pride day	The Lost, rainbow items
July 2nd		???, starts with Forget Me Now and "Ultra Hard" difficulty
July 4th	Independence day	Samson, Dr. Fetus, bomb pool
July 11th		???, to Sheol. Starts with Compost, Rotten Baby and The Mulligan
July 13th		Lazarus, to Mom. Starts with Monster Manual, Robo-Baby and 20/20
August 15th	National Relaxation day	Maggie to The Dark Room. Starts with Brimstone, Rubber Cement, Holy Mantle, Spoon Bender, Tammy's Head; no item rooms.
August 16th	National Tell a Joke day	The Keeper to The Womb. Every pill is Explosive Diarrhea,
August 22nd		Isaac to The Dark Room. Starts with Holy Light, Sacred Heart and Fate
September 5th		Magdalene to Mom. Starts with Stop Watch, Broken Watch and 0.15 Speed
September 17th	National Apple Dumpling day	Cain to Mega Satan. Every boss item is Apple!
September 22nd	Elephant Appreciation Day	Magdalene to The Chest, starts with Bucket Of Lard and Thunder Thighs
October 6th	National Mad Hatter day	Judas to The Dark Room. Starts with Dr. Fetus and Scatter Bombs
October 7th		Isaac to The Cathedral. Starts with Chaos
October 31st	Halloween	Eve, Sack Head
November 1st	Day of the dead	The Lost w/o Holy Mantle, Dead Cat
November 11th	Veterans' day	The Lost, no item rooms
November 13th	World Kindness day	Isaac to It Lives; starts with Blank Card + XX - Judgement, PHD, A Quarter, Habit
November 20th	Thanksgiving	Cupid's Arrow, Rotten Meat
December 5th
December 6th	Satoru Iwata's birthday	Iwata's sprite, The Gamekid
December 25th	Christmas	A Quarter, A Lump of Coal, Xmas hat

The full list of the remaining undisclosed dailies isn't published to avoid spoiling content.