| Date | Event, if any | Peculiarities |
|---|---|---|
| January 1 | New Year's | Starts with 99 bombs (not  Pyro), blindfolded. Only bomb items can be found in Treasure Room Item Pool.
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| January 14 | National Dress Up Your Pet Day | Isaac, starts with  Guppy's Head,  Guppy's Collar, and  Guppy's Tail, no item rooms.
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| January 16 | National Nothing Day | Apollyon, no item rooms, no shops. |
| January 27 | Thomas Crapper Day | ???, starts with  Flush!,  Number One,  Butt Bombs, Error: The given collectible ("No. 2") does not exist. and Error: The given collectible ("E Coli") does not exist., no item rooms, no shops.
|
| February 2 | Groundhog Day | Same seed as the day before. |
| February 9 | National Toothache Day | Cain, starts with  Monstro's Tooth,   Dead Tooth,  Tough Love and 50 luck, no item rooms.
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| February 11 | National "Don't Cry Over Spilled Milk" Day | Magdalene, starts with   Milk! and  Soy Milk.
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| February 14 | Valentine's Day | Magdalene, starts with  Friendly Ball,  The Battery,  Mom's Eyeshadow and 7 luck.
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| February 18 | National Battery Day | Isaac, starts with  9 Volt, The Battery,  Charged Baby,  Mom's Purse,  AAA Battery and  Watch Battery.
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| March 2 | Edmund's birthday | Isaac to Mega Satan, starts with undroppable  The Left Hand.
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| March 4 | Holy Experiment Day | Magdalene, starts with  Eucharist,  Immaculate Conception, and  Seraphim, no Item Rooms.
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| March 17 | St. Patrick's day | Cain to Mega Satan, starts with 18 luck. |
| March 20 | National Alien Abduction Day | Isaac, starts with  Cone Head,  The Parasite, and  Tractor Beam. No item rooms.
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| March 22 | National "Goof off" day | Isaac, starts with extreme range; tears follow random patterns. |
| Easter | Easter | Lazarus, starts with  Blood of the Martyr,  Stigmata, no item rooms.
|
| April 1 | April fools | Old Man Keeper, random trinkets and items upon pickups. |
| April 10 | National siblings day | Lilith, starts with  Brother Bobby,  Ghost Baby,  Little Gish,  Little Steven,  Mongo Baby, and  Sister Maggy.
|
| April 15 | National That Sucks day | Lazarus, starts with  Bob's Brain,  Curse of the Tower,  Cursed Eye,  Dead Cat, and  Tick; no item rooms.
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| April 22 | National Jelly Bean day | Maggie, starts with 9 Volt,  The Black Bean,  Linger Bean, and  Wait What?, no item rooms.
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| May 4 | May the 4th be with you! | Isaac, starts with  Spear Of Destiny and  Technology.
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| May 8 | Mothers' day | Isaac, starts with  Mom's Lipstick,  Mom's Pad and  Mom's Eye, no item rooms.
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| May 13 | National "Stamp Out Hunger" and Frog Jump day | Magdalene, starts with  How to Jump and  Thunder Thighs. No item rooms.
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| May 17 | National "Pack Rat Day" | Isaac, starts with  D20 and  Sack Head.
|
| May 30 | Memorial day | The Lost, no tears, 3 familiars and Conjoined. |
| June 2 | Magdalene, starts with  Blank Card,  II - The High Priestess and undroppable  Mom's Toenail, no item rooms.
| |
| June 5 | World Environment Day | ???, starts with  Gnawed Leaf and  Restock.
|
| June 18 | Fathers' day | Cain, starts with  A Dollar.
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| June 19 | Fathers' day | Cain, starts with  Daddy Longlegs and  Dad's Key.
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| June 25 | Pride day | The Lost, rainbow items. |
| July 2 | I Forgot Day | ???, starts with  Forget Me Now. Permanent Curse of the Lost, Curse of the Blind, and Curse of the Unknown.
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| July 4 | Independence day | Samson, starts with  Dr. Fetus and  Scatter Bombs.
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| July 11 | ???, to Sheol. Starts with  Compost,  The Mulligan, and  Rotten Baby. No Treasure Rooms.
| |
| July 13 | Embrace Your Geekness Day | Lazarus, starts with  20/20,  Monster Manual,  Robo-Baby, and a Dice Shard. No Treasure Rooms.
|
| August 15 | National Relaxation day | Magdalene, starts with  Brimstone,  Holy Mantle,  Rubber Cement,  Spoon Bender, and  Tammy's Head; no item rooms.
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| August 16 | National Tell a Joke day | The Keeper, every pill is Explosive Diarrhea. |
| August 22 | National Be an Angel day | Isaac, starts with  Fate,  Holy Light, and  Sacred Heart.
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| September 5 | National Be Late for Something day | Magdalene to Mom. Starts with  Broken Watch,  Stop Watch, and 0.15 Speed
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| September 17 | National Apple Dumpling day | Cain, every boss item is  Apple!.
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| September 22 | Elephant Appreciation Day | Magdalene to The Chest, starts with  Bucket of Lard and Thunder Thighs.
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| October 6 | National Mad Hatter day | Judas, starts with Dr. Fetus and Scatter Bombs. Only bomb items can be found in Treasure Room Item Pool.
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| October 7 | Isaac to The Cathedral. Starts with  Chaos.
| |
| October 31 | Halloween | Eve, starts with Sack Head.
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| November 1 | Day of the Dead | The Lost, starts with Dead Cat, without Holy Mantle and  D4.
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| November 11 | Veterans' day | The Lost, no item rooms. |
| November 13 | World Kindness day | Isaac to It Lives; starts with  A Quarter, Blank Card +  XX - Judgement,  Habit, and  PHD.
|
| November 19 | National "Have a Bad Day" day | ??? to Mega Satan; starts with Bob's Brain, Cursed Eye, Curse of the Tower, and Scatter Bombs. No item rooms.
|
| November 20 | Thanksgiving | Starts with  Cupid's Arrow. Every boss item is  Rotten Meat.
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| December 5 | Krampusnacht | Isaac to Satan; starts with  A Lump of Coal and  Mitre. Devil Room spawns on first floor with Krampus.
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| December 6 | Satoru Iwata's birthday | Iwata's sprite, starts with  The Gamekid and  Cartridge. Nintendo-themed items in special rooms.
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| December 23 | National Festivus day | Only  The Body,  The Soul,  The Mind and  Godhead can be found in Treasure Room Item Pool.
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| December 25 | Christmas | Isaac, starts with A Quarter, A Lump of Coal, and wearing a Christmas hat. Every item room has 2 items.
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| December 31 | New Year's Eve | Isaac, starts with  More Options and  There's Options.
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The full list of the remaining undisclosed dailies isn't published to avoid spoiling content.