Mom's Heart

Mom's Heart is the final boss in the second floor of the fourth chapter. Until It Lives is unlocked, Mom's Heart cannot be continued past unless a Devil Room or an Angel Room appears, which allow you to go to Sheol or The Cathedral, respectively. After being killed 11 times, Mom's Heart will be permanently replaced by It Lives.

Mom's Heart doesn't drop any items or pickups upon death besides hearts.

Behavior

Mom's Heart acts very differently from the original Binding of Isaac.

At the beginning of the fight, Mom's Heart will always be accompanied by two Eyes.

It has many different types of attacks, seeming to vary depending on the amount of remaining health. Many of the attacks are varying flurries of orbs that scatter across the room, which can be difficult to dodge. These orbs range from several orbs released in every direction while slowly rotating, to a fast moving line of projectiles released in four directions rotating moderately fast.

Mom's Heart also has an attack that shoots blood tears rapidly when it's ~40% lower on HP. Mom's Heart will also retreat upwards and launch blood shots diagonally forward in a spread, at which point it cannot be harmed and it will spawn various enemies. During Mom's Heart's first retreat upwards, Eyes will always be the first wave spawned, after the 2 Eyes that spawn with Mom's Heart are killed. All of its attacks can hurt its own minions.

Enemies spawned by Mom's Heart are:

After losing a significant amount of health (about 90%), Mom's Heart will stop spawning enemies and will begin to shoot four Brimstone lasers that rotate either clockwise or counter-clockwise. At the very top of the boss room is a small area where walking into it counts as though Isaac walked into the heart.

Upon defeat Mom's Heart fires a single ring of tears.

Gallery

Mom's Heart ingame.
Mom's Heart as one of Delirium's forms.

Unlockable Achievements

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Notes

Every time Mom's Heart is defeated changes the current savefile's image until It Lives is unlocked.
Using The Bible against Mom's Heart will kill it instantly.

Trivia

Mom's Heart appeared in the original The Binding of Isaac.
The music that plays during this fight is titled Ventricide. Ventricide is a made-up word formed from the word ventricle (one of the two larger chambers of the heart) and the suffix -cide, which denotes an act of killing. This theme is used in other tracks, such as Matricide, Hericide, and Infanticide.
If Isaac gets hit by Mom's Heart's Brimstone attack, Mom's laugh can be heard.
Mom's Heart can appear as a random boss in The Void, even after being replaced by It Lives in its regular chapter.
In the original Binding Of Isaac, all Mom's Heart did was spawn 2-4 monsters before disappearing and repeating the same move each time the wave of monsters were killed off.

Bugs

Bug!	Sometimes, if the boss intro is skipped, the game will not teleport Isaac into the center of the bottom of the room, resulting in immediate contact damage with one of the Eyes or Mom's Heart, depending on the direction of the room's entrance.