Mom's Key is a passive item.
Effects
- Gives Isaac two
Keys. - If a non- Red Chest spawns hearts, coins, Bombs and/or Keys, causes the chest to spawn a second group of said pickups, effectively doubling the average pickup yield.
- This item belongs to the Yes Mother? set. Collecting three items from this set will transform Isaac into his mother.
This item belongs to the 
Notes
- Mom's Key cannot change the contents of a chest; it will only cause it to spawn extra pickups.
- All other chest rewards (such as pills, cards, items, etc.) will not cause the chest to spawn additional pickups.
- Does not affect Old Chests.
Does not affect 
Synergies
- Sharp Key: Doubles the amount of pickups dropped by enemies.
Interactions
- Mom's Key: Does not further increase the amount of pickups spawned when multiple copies of the item are acquired.
In-game Footage
Trivia
- Mom's Key is the first item, by ID number, that was not carried over from Wrath of the Lamb.
- The appearance of Mom's Key is a reference to Bowser's boss key in Super Mario 64 as well as the Boss Key in various Legend of Zelda games.
- Prior to Repentance, this item's description was "Less is now more +2 keys".
Prior to Repentance, this item's description was "Less is now more +2 keys". Keys
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| Trinkets |
| Cards and Runes |
 The Binding of Isaac: Rebirth
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