Placebo is an activated item added in Afterbirth.
Effect
- Mimics the effect of Isaac's held pill, like
Blank Card does with cards or runes.
- Does not consume Isaac's held pill.
- Does not mimic cards or runes.
Synergies
- Balls Of Steel + Sharp Plug: The player can gain functional invincibility.
- 48 Hour Energy: Can spawn an unlimited number of Lil' Batteries, allowing unlimited use of another activated item or pill.
Interactions
- Starter Deck: All pills are replaced by cards, rendering Placebo useless.
In-game Footage
Trivia
- Placebo is a medicine or procedure prescribed for the psychological benefit to the patient rather than for any physiological effect.
 Pill Items
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 The Binding of Isaac: Rebirth
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