After obtaining 3 holy items listed below (angel item tagSoul Hearts and permanent flight.
Activated Collectibles [ | ] Passive Collectibles [ | ]
Name
ID
Icon
Quote
Description
Dead Dove
5.100. 185
Flight + spectral tears
Grants spectral tears and flight .
3
Holy Grail
5.100. 184
Flight + HP up
Grants flight and one Red Heart container . Red Heart .
3
Holy Mantle
5.100. 313
Holy shield
Grants a shield that negates the first instance of damage taken, once per room. Does not apply to or negate self-damage (Blood Donation Machines , etc).
4
Mitre
5.100. 173
Blessing of purity
Grants a chance of converting any Red Heart pickups into Soul Hearts instead.
3
Rosary
5.100. 72
Tears + faith up
Grants 3 Soul Hearts . Causes The Bible item pool . tears .
2
The Halo
5.100. 101
All stats up
Heart container , +0.3 damage , +0.2 tears , +0.25 range , +0.3 speed , and +0.5 tear falling speed .Heart container , +0.3 damage , +0.2 tears , +1.5 range , and +0.3 speed . Heals 1 additional Red Heart .
2
Guardian Angel
5.100. 112
Extra protection
Spawns an orbital familiar that blocks enemy shots, deals
2
Sworn Protector
5.100. 363
Protective friend
Spawns an orbital familiar which does 105 damage per second and attracts and blocks enemy shots. Upon blocking 10 shots in a room , it drops an Eternal Heart .
3
Celtic Cross
5.100. 162
Blessing of protection
Grants a chance to trigger the Book of Shadows shield that nullifies all types of damage for 7 seconds.
1
Divine Intervention
5.100. 568
Double tap shield
Double tapping a fire key creates a shield that pushes away enemies and reflects enemy projectiles and lasers.
2
Godhead
5.100. 331
God tears
homing tears with a damaging halo. +0.5 Damage , -0.3 Tears -0.3 Shot Speed , +0.8 Tear Falling Speed , and +1.2 Range .homing tears with a damaging halo. +0.5 Damage , -0.3 Tears , and -0.3 Shot Speed .
4
Holy Light
5.100. 374
Holy death shot
Adds a chance to fire holy tears, which will create a damaging light beam in the area if they hit an enemy.
3
Immaculate Heart
5.100. 573
Halo of tears
Adds one Red Heart Container and fully restores health. x1.2 damage multiplier. Isaac will occasionally fire extra tears that orbit around him.
3
Revelation
5.100. 643
Awaken your faith
Grants flight and two Soul Hearts . In addition to tears, Isaac can charge up and fire a powerful holy laser.
4
Sacred Heart
5.100. 182
Homing shots + DMG up
Heart Container . Grants homing tears , a x2.3 Damage multiplier, +1 flat Damage, -0.4 Tears , -0.25 Shot Speed , and +4.125 Range .Heart Container . Grants homing tears , a x2.3 Damage multiplier, +1 flat Damage, -0.4 Tears , and -0.25 Shot Speed .4
Sacred Orb
5.100. 691
Destined for greatness
Prevents items of quality 0-1 from appearing, and items of quality 2 from appearing 33% of the time, greatly increasing the quality of items received from all item pools . Quest items are unaffected.
4
Salvation
5.100. 696
Divine protection
Gives Isaac a halo that summons beams of light on enemies inside it. The halo grows larger the more times Isaac has taken damage this floor.
3
Scapular
5.100. 142
Pray for a miracle
Once per room, when Isaac is reduced to his last half heart, he is granted one Soul Heart .
2
Notes [ | ] Despite having the same name, the familiar Seraphim
Picking up and dropping multiple, distinct copies of The Bible Rosary Rosary Bead
Super Bum
Bookworm
3 items with the 
Soul Hearts and permanent flight.
Mom, 
Mom's Heart, and 
It Lives when activated, but kills Isaac when used on 
Satan.
Red Heart.
Blood Donation Machines, etc).
The Bible to appear in any item pool. 
Grants one full Red Heart container, +0.3 damage, +0.2 tears, +0.25 range, +0.3 speed, and +0.5 tear falling speed.
Eternal Heart.
Book of Shadows effect upon taking damage, creating a shield that nullifies all types of damage for 7 seconds.
Seraphim does not contribute to the Seraphim transformation.
The Binding of Isaac: Rebirth
