The 12 Signs of the Zodiac are featured as passive collectible items based on the 12 astrological signs.
Items
Astrological Significance
Some of the effects caused by the items in-game are directly related to their astrological significance or symbol. For example, Aquarius is portrayed as a man (Ganymede) bearing water, and in game the item causes Isaac to leave a trail of tears behind him while walking; Libra, which represents weighing scales, balances Isaac's stats.
 The Binding of Isaac: Rebirth
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