Spiders move quickly and will go in all directions randomly, making them unpredictable. However, if they have a direct line of sight on Isaac, and are close enough, they will move towards him. They are also able to fit through small diagonal gaps.
Variations
Big Spider
Big Spiders look like regular spiders, but with a large black abdomen attached. They behave in the same way as the regular spiders, having the same movement speed and erratic behavior. However, they have nearly triple the health of regular spiders, and on death, they will split into two regular spiders. They will not split if they are killed by an explosion.
Notes
The following spiders will not attack Isaac, deal contact damage or actively spawn enemies if he has Bursting Sack:
- Spider, Big Spider, lvl2 Spider, Ticking Spider, Baby Long Legs, Small Baby Long Legs, Crazy Long Legs and Small Crazy Long Legs.
- Spiders and Big Spiders no longer blink red when neutral due to it.
The following spiders will not attack Isaac, deal contact damage or actively spawn enemies if he has 
Spiders and Big Spiders no longer blink red when neutral due to it.Gallery
Spider on Isaac's Last Will.
 The Binding of Isaac: Rebirth
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