This article is about the trinket. For the item, see Stem Cells.
Stem Cell is an unlockable trinket added in The Binding of Isaac: Afterbirth †.
Effect[ | ]
Heals for a Half Red Heart upon traveling to the next floor.- Heals 50% of Isaac's empty Red Hearts and Bone Hearts (rounded down), but at minimum a half heart, upon traveling to the next floor.
Heals for a 
Synergies[ | ]
- Blood Oath: The healing will occur before any health is drained, allowing for a greater stat bonus.
- Glowing Hourglass: Returning to a previous floor will keep the health gained from Stem Cell, as well as granting another half-red heart after going down to the next floor again.
- Tainted Magdalene: Since all red heart healing is doubled, Stem Cell will bring her to full health.
Interactions[ | ]
- Golden Trinket / Mom's Box: No effect.
- Tainted Bethany: Adds 1 blood charge.
In-game Footage[ | ]
Trivia[ | ]
- A Stem Cell is an undifferentiated cell of a multicellular organism that is capable of giving rise to indefinitely more cells of the same type, and from which certain other kinds of cells arise by differentiation.
 Samson Unlocks
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 Ultra Greedier Unlocks
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 The Binding of Isaac: Rebirth
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