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Quote "Doples do not shoot back if Isaac attacks with Brimstone or similar attack modifying items, because the Dople's attack is based on the attack key being pressed as opposed to actual attacks by Isaac. In case of Brimstone, the Dople will attack when the beam first started to charge up for example."
After several runs with Azazel, I never saw a single Dople shooting at me, even if I'm charging the attack... I think they don't shoot blood at all if you don't shoot tears. Can someone confirm?