Toxic Shock is a passive item added in the Binding of Isaac: Afterbirth expansion.
Effects
- Upon entering a room, all enemies are poisoned, dealing double Isaac's tear damage and also creating a green fog for the first few seconds of the room.
- Killing enemies leaves a small, short lasting pool of green creep on the ground.
- The creep deals 1 damage per tick or 30 damage per second.
Notes
- High tear damage will cause this item to become very powerful for rooms with a lot of enemies, since they can die instantly and render the room harmless.
- Enemies which spawn after the first few seconds of each room are not affected by this item, e.g. Flies spawned from a Mulligan dying.
- The poison effect only activates upon entering a room and not at the start of a wave. In Boss Rush and most of Greed Mode, the item will not poison enemies.
In-game Footage
Trivia
Contagion is a recolor of its sprite.- Toxic Shock is a rare, but extremely serious and deadly condition caused by Staphylococcus Aureus bacteria releasing toxins in the bloodstream.
Seeds
PC MS6L 43MM (First floor treasure room) (Hard Mode Only)
PC 0DMW R92S (First floor treasure room)
PC E3ER VEGE (First floor treasure room) (Both modes)
Switch 
7YV6 DDJ1 (Treasure room adjacent to spawn)