Binding of Isaac: Rebirth Wiki
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Name ID Icon Quote Description (in Repentance) Quality
Anarchist Cookbook 5.100.65
Anarchist Cookbook
3 rooms
Summon bombs Spawns six Troll BombTroll Bombs around the room. 1
Blank Card 5.100.286
Blank Card
Variable
Card mimic (except in Repentance) Copies the effect of the card or rune currently held by Isaac.
(in Repentance) Copies the effect of the card currently held by Isaac. The charge time is based on the power of the card.
2
Book of Secrets 5.100.287
Book of Secrets
6 rooms
Tome of knowledge Gives the effect of Collectible Treasure Map iconTreasure Map, Collectible The Compass iconThe Compass, or Collectible Blue Map iconBlue Map for the duration of the current floor. (in Repentance) If all effects are active, Collectible X-Ray Vision iconX-Ray Vision is provided for the floor instead. Highlights any Tinted Rocks and rocks with Crawl SpaceCrawl Space in the room. 1
Box of Spiders 5.100.288
Box of Spiders
2 rooms
It's a box of spiders (except in Repentance) Spawns 1-4 Blue Spiders that deal 2.5x Isaac's damage to enemies.
(in Repentance) Spawns 4-8 Blue Spiders that deal 2x Isaac's damage to enemies.
1
Breath of Life 5.100.326
Breath of Life
3 seconds
Invincibility at a cost Grants a brief moment of invincibility when the charge bar hits zero. Isaac begins taking damage if the item is held any longer. (in Repentance) Isaac creates beams of light when touching enemies while invulnerable, and creates a powerful 4-way beam if blocking damage exactly as the invincibility starts. 1
Butter Bean 5.100.294
Butter Bean
3 seconds
Reusable knock-back Upon use, Isaac farts and knocks back nearby enemies (except in Rebirth) and projectiles. (in Repentance) Enemies pushed into walls or obstacles take 12 damage. 1
Crack the Sky 5.100.160
Crack the Sky
4 rooms
Holy white death Summons 5 beams of light in random locations on the ground, dealing large amounts of damage to any enemies that touch them. 2
Crystal Ball 5.100.158
Crystal Ball
6 rooms
I see my future Upon use, reveals the map (except the Super Secret RoomSuper Secret Room and Ultra Secret RoomUltra Secret Room) and drops a Soul HeartSoul Heart or random card/rune. 3
D100 5.100.283
D100
6 rooms
REEROLLLLL! (except in Repentance) Combines the effects of Collectible D4 iconD4, Collectible The D6 iconThe D6, and Collectible D20 iconD20.
(in Repentance) Combines the effects of Collectible D1 iconD1, Collectible D4 iconD4, Collectible The D6 iconThe D6, Collectible D7 iconD7, Collectible D8 iconD8, Collectible D10 iconD10, Collectible D12 iconD12, and Collectible D20 iconD20.
3
Mom's Pad 5.100.41
Mom's Pad
2 rooms
Mass fear Inflicts fear to all enemies in the room for 4 seconds. (in Repentance) Spawns a blue fly. 0
Monstro's Tooth 5.100.86
Monstro's Tooth
3 rooms
Summon Monstro A friendly Boss Monstro ingameMonstro jumps on a random enemy, dealing 120 area damage. Targets Isaac if used in a room without enemies. 1
My Little Unicorn 5.100.77
My Little Unicorn
4 rooms
Temporary badass Gives invulnerability and +0.28 speed for six seconds, removing the ability to shoot tears and replacing it with the ability to deal contact damage to enemies. 1
Unicorn Stump 5.100.298
Unicorn Stump
1 room
You feel stumped Gives invulnerability and increased speed for six seconds, but removes the ability to shoot tears. 1
White Pony 5.100.181
White Pony
2 rooms
Flight + holy death Passively grants flight and increases speed to 1.5. Upon use, Isaac charges in the direction the pony is facing, giving invulnerability during the charge while also creating damaging beams of light. 2

Passive[ | ]

Name ID Icon Quote Description (in Repentance) Quality
Best Bud 5.100.274 Best Bud Sworn protector When hit, spawns a quickly orbiting attack fly similar to Collectible Forever alone iconForever alone for the current room that deals high damage. 0
Breakfast 5.100.25 Breakfast HP up Grants one full Red Heart container. (in Repentance) Heals 1 additional Red HeartRed Heart. 1
Bucket of Lard 5.100.129 Bucket of Lard HP up (except in Repentance) Grants two empty Red Heart containers, heals Isaac for a Half Red HeartHalf Red Heart, -0.2 speed.
(in Repentance) Grants two Red Heart containers, -0.2 speed.
1
Caffeine Pill 5.100.340 Caffeine Pill Speed up + size down Grants +0.3 speed, reduces character size, and gives a random pill. 1
Cain's Other Eye 5.100.319 Cain's Other Eye Near-sighted friend (except in Repentance) Spawns a familiar that slowly floats around the room on a zig-zag pattern and shoots normal tears in the same direction as Isaac.
(in Repentance) Spawns a familiar that follows Isaac and fires tears in random cardinal directions that copy Isaac's tears and tear effects and scale with damage.
2
Cursed Eye 5.100.316 Cursed Eye Cursed charge shot Grants charged tears that can be fired in a tight burst. Getting hit while charging will teleport Isaac to another room. 0
Daddy Longlegs 5.100.170 Daddy Longlegs Daddy's love Daddy Long Legs' shadow follows Isaac and occasionally stomps enemies for 40 damage total. 3
Dead Dove 5.100.185 Dead Dove Flight + spectral tears Grants spectral tears and flight. 3
Distant Admiration 5.100.57 Distant Admiration Attack fly Spawns an attack fly that circles further out than Collectible Halo of Flies iconHalo of Flies, but closer than Collectible Forever alone iconForever alone, dealing 75 damage per second. 2
Epic Fetus 5.100.168 Epic Fetus On-demand air strike Isaac's tears are replaced with guided missiles, like those used by the Collectible Doctor's Remote iconDoctor's Remote. 4
Ghost Baby 5.100.163 Ghost Baby Spectral buddy Spawns a familiar that follows Isaac around and fires spectral tears. 1
Guillotine 5.100.206 Guillotine DMG + tears up. An out-of-body experience! Isaac's head is removed from his body and floats around him as an orbital. (except in Repentance) Gives +1 damage and grants -1 tear delay. (in Repentance) Gives +1 damage and grants +0.5 fire rate. 2
Headless Baby 5.100.269 Headless Baby Bloody friend Spawns a familiar that follows Isaac, leaving blood creep on the ground. 1
Juicy Sack 5.100.266 Juicy Sack Sticky babies Spawns a familiar that follows Isaac and drips a trail of slow creep, spawning 1-2 Blue Spiders after each room. 2
Lazarus' Rags 5.100.332 Lazarus' Rags Eternal life? (except in Repentance) Upon dying, resurrect as Character Lazarus Risen iconLazarus Risen in the current room with one Red Heart container and Collectible Anemic iconAnemic.
(in Repentance) Upon dying, resurrect as Character Lazarus Risen iconLazarus Risen in the current room with one less Red Heart container, Collectible Anemic iconAnemic, and +0.5 Damage. Transform into Character Lazarus iconLazarus when reaching the next floor.
1
Lil Haunt 5.100.277 Lil Haunt Fear him Spawns a familiar that chases down enemies, dealing 4 damage per second and inflicting fear. 1
Lost Contact 5.100.213 Lost Contact Shielded tears Isaac's tears can hit and destroy enemy projectiles. -0.15 shot speed. 2
Mom's Eye 5.100.55 Mom's Eye Eye in the back of your head Gives Isaac a chance to fire tears from the back of his head. 1
My Reflection 5.100.5 My Reflection Boomerang tears + DMG up + luck down Gives Isaac's tears a boomerang effect. (except in Repentance) +1.5 range, +1 tear falling speed, x1.6 shot speed multiplier. (in Repentance) 2x + 1.5 range, +1.5 damage, -1 luck, 1.6x shot speed multiplier. 2
PHD 5.100.75 PHD Better pills Converts all bad pills into good pills, spawns one pill pickup, and identifies all pills. Restores two Red HeartRed Hearts and increases the payout of Blood Donation MachineBlood Donation Machines. 2
Polyphemus 5.100.169 Polyphemus Mega tears Isaac fires huge tears that deal massive damage, but fire rate is greatly decreased. If a tear kills an enemy, it travels on with any leftover damage. 4
Robo-Baby 5.100.95 Robo-Baby Friends 'till the bbbbzzzt Spawns a familiar that shoots Collectible Technology iconTechnology lasers. 1
Speed Ball 5.100.143 Speed Ball Speed + shot speed up +0.3 speed, +0.2 shot speed. 2
The Inner Eye 5.100.2 The Inner Eye Triple shot Grants triple shot but decreases tears. 2
The Ludovico Technique 5.100.329 The Ludovico Technique Controlled tears Instead of firing tears, Isaac controls one floating tear that hover over obstacles. This tear deals constant damage when held in place over an enemy. 2
The Pact 5.100.80 The Pact DMG + tears up (except in Repentance) Grants two Soul HeartSoul Hearts, +0.5 damage, and +0.7 tears.
(in Repentance) Grants two Black HeartBlack Hearts, +0.5 damage, and +0.7 tears.
3
The Peeper 5.100.155 The Peeper Plop! Spawns a familiar that slowly floats around the room in a zig-zag pattern, damaging enemies it passes through. (in Repentance) Increases the damage of tears from Isaac's left eye by 35%. 2
The Polaroid 5.100.327 The Polaroid Fate chosen If Isaac has half a red heart or no red hearts after taking damage, he gains a shield that nullifies all types of damage for 5 seconds. Allows entrance into ChestChest. (in Repentance) Also allows access to HomeHome. 2
There's Options 5.100.249 There's Options More options Two items appear after defeating a Boss. Only one can be taken; the other will disappear. 3
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Active[ | ]

Name ID Icon Quote Description (in Repentance) Quality
Book of Shadows 5.100.58
Book of Shadows
3 rooms
Temporary invincibility Creates a protective shield, nullifying all types of damage in the current room for 10 seconds. 3
Doctor's Remote 5.100.47
Doctor's Remote
2 rooms
Reusable air strike Creates a crosshair on the ground that can be aimed with tear controls. A missile strikes the spot after 2 seconds, creating a heavy damage explosion. 1
Flush! 5.100.291
Flush!
4 rooms
... Turns all non-boss monsters in the room into PoopPoop. Instantly kills poop-themed bosses. 1
Forget Me Now 5.100.127
Forget Me Now
One time use
I don't remember... On use, re-generates the current floor with a new layout. Isaac loses Forget Me Now, but keeps other items and consumables picked up on the original floor. 3
Head of Krampus 5.100.293
Head of Krampus
3 rooms
Krampus rage (except in Afterbirth) Fires a powerful Collectible Brimstone iconBrimstone beam in four cardinal directions, much like Boss Krampus ingameKrampus shoots.

(in Afterbirth) Fires a powerful Collectible Brimstone iconBrimstone beam in four cardinal directions, much like Boss Krampus ingameKrampus shoots with a 50% chance to rotate all beams around Isaac 90 degrees.

2
How to Jump 5.100.282
How to Jump
Unlimited
It's time you learned how Upon use, Isaac jumps in the direction he is currently moving, allowing travel over obstacles and enemies. 1
Mr. Boom 5.100.37
Mr
2 rooms
Reusable bomb buddy (except in Repentance) Places a Collectible Mr. Mega iconMr. Mega BombBomb that deals 110 damage.
(in Repentance) Places a Collectible Mr. Mega iconMr. Mega BombBomb that deals 185 damage.
1
Notched Axe 5.100.147
Notched Axe
Unlimited
Rocks don't stand a chance (except in Repentance) Isaac destroys obstacles and opens Secret RoomSecret Rooms by walking into them, but cannot shoot or pick up items until it's cancelled.
(in Repentance) Toggles between tears and the pickaxe, which can be swung to attack and break obstacles. Using it depletes the charge, and it can't be used until next floor once the charge runs out.
1
Razor Blade 5.100.126
Razor Blade
Unlimited
Feel my pain Takes one Red HeartHeart of health and grants +1.2 damage for the current room. (in Repentance) Repeated uses in the same room only take half a heart. 0
Scissors 5.100.325
Scissors
4 rooms
Lose your head Turns Isaac's head into a stationary familiar for the current room which fires tears automatically. (in Repentance) Isaac's body also shoots a controllable fountain of blood shots for the room. 1
Spider Butt 5.100.171
Spider Butt
2 rooms
Mass enemy slowdown + damage Deals 10 damage to all enemies in the room and slows them for 4 seconds. (in Repentance) Enemies killed by Spider Butt spawn Blue Spiders. 1
The Gamekid 5.100.93
The Gamekid
4 rooms
Temporary Man-Pac Turns Isaac into a Pac-Man-like creature for 6.5 seconds, granting invulnerability, inflicting fear on all enemies, and has a chance of replenishing a Half Red HeartHalf Red Heart every time an enemy is killed. 1
The Nail 5.100.83
The Nail
6 rooms
Temporary demon form (except in Repentance) Gives one Soul HeartSoul Heart. For the current room; +0.7 damage, -0.18 speed, Isaac breaks rocks and deals contact damage.
(in Repentance) Gives half a Black HeartBlack Heart. For the current room; +2 damage, -0.18 speed, Isaac breaks rocks and deals contact damage.
2
The Pinking Shears 5.100.107
The Pinking Shears
4 rooms
Cut and run Separates Isaac's head from his body for the current room, granting flight and turning the body into a familiar that chases enemies. 2

Passive[ | ]

Name ID Icon Quote Description (in Repentance) Quality
A Quarter 5.100.74 A Quarter +25 coins Gives Isaac 25 Pennycoins. 0
Ankh 5.100.161 Ankh Eternal life? Upon death, Isaac will respawn as Character ??? (Character) icon??? in the previous room, with 3 Soul HeartSoul Hearts. 1
BOGO Bombs 5.100.250 BOGO Bombs 1+1 BOOM! All normal BombBombs become Double BombDouble Bombs. 1
Bomb Bag 5.100.131 Bomb Bag Gives bombs Spawns a familiar that drops a BombBomb every 3 rooms. 2
Boom! 5.100.19 Boom! 10 bombs Grants 10 BombBombs. 0
Cupid's Arrow 5.100.48 Cupid's Arrow Piercing shots Grants Isaac piercing tears that travel through enemies (but not obstacles) instead of breaking on impact with them. 3
Death's Touch 5.100.237 Death's Touch Piercing shots + DMG up +1.5 damage, -0.3 tears. Tears are replaced with large piercing scythes. 3
Dry Baby 5.100.265 Dry Baby Immortal friend Spawns a familiar that follows Isaac around and blocks enemy projectiles. Upon blocking a shot, it has a chance of triggering Collectible The Necronomicon iconThe Necronomicon effect. 3
Hot Bombs 5.100.256 Hot Bombs Burning blast +5 bombs +5 BombBombs. Isaac's bombs leave behind fire that damages enemies upon contact. 1
Iron Bar 5.100.201 Iron Bar DMG up + concussive tears +0.3 damage. Adds a chance to shoot concussive tears, causing enemies to walk around randomly. 2
Match Book 5.100.344 Match Book Evil up Grants Isaac one Black HeartBlack Heart, spawns two or three BombBombs. 1
Mom's Knife 5.100.114 Mom's Knife Stab stab stab Isaac's tears are replaced by a knife that pierces enemies, can travel through obstacles, and can hurt enemies while Isaac is holding it. Holding down the fire button before firing increases its range and power. 4
Mr. Mega 5.100.106 Mr Bigger boom +5 BombBombs. Increases the size, blast radius, and damage of Isaac's bombs. 2
Old Bandage 5.100.219 Old Bandage HP up Grants an empty Red Heart container. Adds a chance of dropping a Red HeartRed Heart after taking damage. 2
Pyro 5.100.190 Pyro 99 bombs Grants 99 BombBombs. 3
Robo-Baby 2.0 5.100.267 Robo-Baby 2 We worked out all the kinks Spawns a familiar that fires lasers at any enemy in its line of sight and moves based on the direction Isaac is firing tears. 1
Sacrificial Dagger 5.100.172 Sacrificial Dagger My fate protects me Spawns a dagger orbital familiar, blocking enemy shots and dealing a high amount of damage to enemies in contact. 2
Sad Bombs 5.100.220 Sad Bombs Tear blasts +5 bombs +5 BombBombs. Upon exploding, bombs shoot 10 tears around them, affected by tear modifiers. 2
Safety Pin 5.100.339 Safety Pin Evil + range + shot speed up (except in Repentance) Grants one Black HeartBlack Heart, +5.25 range, +0.5 tear falling speed, +0.16 shot speed.
(in Repentance) Grants one Black HeartBlack Heart, +2.5 range, +0.16 shot speed.
1
Screw 5.100.255 Screw Tears + shot speed up +0.5 tears, +0.2 shot speed. 3
Sharp Plug 5.100.205 Sharp Plug Infinite charge... at a cost Damages Isaac in exchange for fully recharging Isaac's current activated item. 2
Skeleton Key 5.100.17 Skeleton Key 99 keys Gives Isaac 99 KeyKeys. 3
Spelunker Hat 5.100.91 Spelunker Hat See-through doors Reveals type of adjacent rooms, including location for Secret RoomSecret Rooms and Super Secret RoomSuper Secret Rooms. (in Repentance) Reveals rooms up to 2 rooms away and blocks projectiles falling from above. 2
Spoon Bender 5.100.3 Spoon Bender Homing shots Grants Isaac homing tears. 3
Synthoil 5.100.345 Synthoil DMG + range up (except in Repentance) +1 damage, +5.25 range, +0.5 tear falling speed.
(in Repentance) +1 damage, +2.5 range.
3
Tech.5 5.100.244 Tech It's still being tested... Isaac occasionally fires an unlimited range piercing laser alongside his normal tears. The laser can glitch, mimicking the effects of certain items and trinkets. 3
Technology 5.100.68 Technology Laser tears Replaces tears with a piercing laser with unlimited range. 3
Technology 2 5.100.152 Technology 2 Extra laser Replaces the tears fired from Isaac's right eye with a rapid-firing low damage piercing laser. (except in Repentance) Damage down. 2
The Battery 5.100.63 The Battery Stores energy Activated collectibles can store an extra level of charge, allowing them to be used twice in one room. 2
The Small Rock 5.100.90 The Small Rock DMG up + speed down +1 damage, +0.2 tears, -0.2 speed. 3
Tiny Planet 5.100.233 Tiny Planet Orbiting tears + range up Massively increases Range and grants spectral tears. Tears orbit around Isaac at a fixed distance until they hit the ground. 0
Torn Photo 5.100.341 Torn Photo Tears + shot speed up +0.7 tears, +0.16 shot speed. 3
Tough Love 5.100.150 Tough Love Tooth shot Adds a chance to shoot a tooth instead of a tear, which deals x3.2 Isaac's damage. 3
[edit]

Active[ | ]

Name ID Icon Quote Description (in Repentance) Quality
Guppy's Head 5.100.145
Guppy's Head
1 room
Reusable fly hive Spawns 2-4 friendly Blue Flies that damage enemies. 2
Guppy's Paw 5.100.133
Guppy's Paw
Unlimited
Soul converter Upon use, converts one Red Heart Container into three Soul HeartSoul Hearts. 3
Kamikaze! 5.100.40
Kamikaze!
Unlimited
Become the bomb! Creates an explosion around Isaac, damaging him and nearby enemies as well as destroying obstacles. 0
Satanic Bible 5.100.292
Satanic Bible
6 rooms
Reusable evil... but at what cost? Gives one Black HeartBlack Heart. (in Repentance) Replaces the boss room item on the current floor with a Devil Deal. 4
The Book of Belial 5.100.34
The Book of Belial
3 rooms
Temporary DMG up (in Rebirth) +2 damage for the current room. Passively guarantees a Devil RoomDevil Room or Angel RoomAngel Room will appear while held.
(except in Rebirth) +2 damage for the current room. Passively increases the chance of finding a Devil RoomDevil Room or Angel RoomAngel Room while held.
2
The Book of Sin 5.100.97
The Book of Sin
4 rooms
Reusable item generator Generates a random pickup, pill, card, or rune. 2
The Jar 5.100.290
The Jar
Unlimited
Save your life When at full health, up to 4 extra Red HeartRed Hearts can be stored in The Jar. Activating drops the stored hearts on the ground. 0

Passive[ | ]

Name ID Icon Quote Description (in Repentance) Quality
20/20 5.100.245 20/20 Double shot Isaac fires two tears at once, one from each eye. (in Repentance) 0.8x damage multiplier. 4
9 Volt 5.100.116 9 Volt Quicker charge Reduces the charge of any activated item by 1. Any 1 charge items instead have timed recharges. 2
A Lump of Coal 5.100.132 A Lump of Coal My Xmas present The more distance tears travel, the more damage they will do. 3
Ball of Tar 5.100.231 Ball of Tar Sticky feet... Adds a chance to shoot slowing tears. Isaac leaves a trail of slowing creep behind as he moves, impeding enemies' speed. 2
BBF 5.100.272 BBF Big Beautiful Fly Spawns a familiar that flies around the room in a zig-zag pattern and explodes on contact with an enemy. Respawns after ten seconds. 1
Black Candle 5.100.260 Black Candle Curse immunity + evil up Prevents curses. Grants one Black HeartBlack Heart. Increases the chance for a Devil RoomDevil Room or Angel RoomAngel Room to appear. 3
Black Lotus 5.100.226 Black Lotus HP up x3! Grants one Red Heart Container, one Soul HeartSoul Heart, and one Black HeartBlack Heart. 2
Bobby-Bomb 5.100.125 Bobby-Bomb Homing bombs! +5 BombBombs. Bombs gain a homing effect, slowly moving towards the nearest enemy. 2
Cat-o-nine-tails 5.100.165 Cat-o-nine-tails Shot speed + damage up +1 damage, +0.23 shot speed. 3
Celtic Cross 5.100.162 Celtic Cross Blessing of protection Grants a chance to trigger the Collectible Book of Shadows iconBook of Shadows effect upon taking damage, creating a shield that nullifies all types of damage for 7 seconds. 1
Ceremonial Robes 5.100.216 Ceremonial Robes DMG + evil up Grants 3 Black HeartBlack Hearts, and +1 damage. 3
Charm of the Vampire 5.100.62 Charm of the Vampire DMG up + kills heal Heals Isaac for a Half Red HeartHalf Red Heart for every 13 enemies killed. (in Repentance) +0.3 damage. 1
Dark Bum 5.100.278 Dark Bum He wants to take your life Spawns a familiar that follows Isaac around and collects Red HeartRed Hearts. For every 1½ Red Hearts collected, Dark Bum will give a reward. 3
Dark Matter 5.100.259 Dark Matter DMG up + fear shot +1 damage, adds a chance to shoot fear tears. 3
Dead Bird 5.100.117 Dead Bird Protective buddy After Isaac takes damage, spawns a flying familiar that chases enemies for the current room, dealing ~4 damage per second. 0
Dead Cat 5.100.81 Dead Cat 9 lives Sets Isaac's Red Heart Containers to 1, but grants 9 extra lives. After dying, Isaac respawns with 1 Red Heart Container. 3
Demon Baby 5.100.113 Demon Baby Auto-turret friend Spawns a familiar that follows Isaac and automatically fires at enemies in its reach. 2
Eve's Mascara 5.100.310 Eve's Mascara DMG up, tears + shot speed down (except in Repentance) Doubles damage, halves tears stat, and greatly reduces shot speed.
(in Repentance) Doubles damage, 0.66x tears multiplier, and greatly reduces shot speed.
3
Gimpy 5.100.225 Gimpy Sweet suffering Gives chance of spawning a Soul HeartSoul Heart when taking damage. Enemies have a chance to drop a Half Red HeartHalf Red Heart after being killed. 2
Guppy's Tail 5.100.134 Guppy's Tail Cursed? Room Clear Awards have a 1/3 chance of being replaced with a ChestChest and a 2/9 chance being replaced with nothing. 2
Habit 5.100.156 Habit Item martyr When Isaac is hit, his active item gains 1 room's worth of charge. 2
Halo of Flies 5.100.10 Halo of Flies Projectile protection Spawns two Pretty Flies that block enemy shots and deal contact damage to flies. 2
Judas' Shadow 5.100.311 Judas' Shadow Sweet revenge Upon death, respawns Isaac as Character Dark Judas iconDark Judas with two Black HeartBlack Hearts in the previous room. 3
Leech 5.100.270 Leech Blood sucker Spawns a leech familiar that chases enemies, dealing ~3 damage per second. Heals a Half Red HeartHalf Red Heart whenever Leech kills an enemy. 2
Lil Brimstone 5.100.275 Lil Brimstone Evil friend Grants a familiar that charges a thin Collectible Brimstone iconBrimstone laser while Isaac is shooting. 2
Little Gish 5.100.99 Little Gish Sticky friend Spawns a familiar that follows Isaac around and fires slowing tears, impeding enemies' speed. 2
Little Steven 5.100.100 Little Steven Psychic friend Spawns a familiar who follows Isaac around and fires homing tears. 2
Loki's Horns 5.100.87 Loki's Horns Cross tears Gives a random chance for projectiles to fire in all 4 cardinal directions. 1
Magic 8 Ball 5.100.194 Magic 8 Ball Shot speed up +0.16 shot speed, spawns a random tarot card. (in Repentance) Increases the chance of finding a PlanetariumPlanetarium. 1
Mom's Eyeshadow 5.100.200 Mom's Eyeshadow Charm tears Tears have a chance to charm enemies. 1
Samson's Chains 5.100.321 Samson's Chains The ol' ball and chain Attaches a ball and chain to Isaac that pulls behind him that damages enemies, blocks shots, and destroys most Obstacles. 1
Skatole 5.100.9 Skatole Fly love Flies become harmless or less dangerous depending on the type. 0
Spider Bite 5.100.89 Spider Bite Slow effect Adds a chance to shoot slowing tears, reducing speed of enemy movement and any projectile fired by them. 2
Spirit of the Night 5.100.159 Spirit of the Night Scary Grants spectral tears and flight. 3
Steven 5.100.50 Steven DMG up +1 damage. 3
Strange Attractor 5.100.315 Strange Attractor Magnetic tears Pickups, trinkets, and monsters are magnetically attracted to Isaac's tears. 0
The Black Bean 5.100.180 The Black Bean Toot on touch (except in Repentance) When taking damage, Isaac farts, poisoning enemies in range.
(in Repentance) When taking damage, Isaac farts five times, poisoning and knocking back nearby enemies and leaving lingering poison clouds.
0
The Negative 5.100.328 The Negative Fate chosen If Isaac has half a red heart or no red hearts after taking damage, all enemies in the room take significant damage. Allows entrance into the Dark RoomDark Room. (in Repentance) +1 Damage and also allows access to HomeHome. 2
Whore of Babylon 5.100.122 Whore of Babylon Curse up Grants +1.5 Damage and +0.3 Speed whenever Isaac has a Half Red HeartHalf Red Heart or less. 2
Wire Coat Hanger 5.100.32 Wire Coat Hanger Tears up Increases tears by 0.7. 3
X-Ray Vision 5.100.76 X-Ray Vision I've seen everything Reveals and opens all Secret RoomSecret Room and Super Secret RoomSuper Secret Room entrances. 2
[edit]

Active[ | ]

Name ID Icon Quote Description (in Repentance) Quality
D20 5.100.166
D20
6 rooms
Reroll the basics Rerolls all pickups in the current room. 2
IV Bag 5.100.135
IV Bag
Unlimited
Portable blood bank Upon use, Isaac loses half a heart of health (or a full heart in Chapter 4 onward) for a random amount of coins, similar to a Blood Donation MachineBlood Donation Machine. 1
Portable Slot 5.100.177
Portable Slot
Unlimited
Gamble 24/7 Upon use, consumes 1 PennyPenny and has a chance to drop a random pickup, like a Slot MachineSlot Machine. 0
Red Candle 5.100.289
Red Candle
4 seconds
Flame on Throws out a flame that damages everything in its path, diminishing in size as it hits enemies or blocks shots. 2
Remote Detonator 5.100.137
Remote Detonator
Unlimited
Remote bomb detonation BombBombs placed by Isaac only explode when Remote Detonator is used. Gives 5 bombs. 1
Shoop da Whoop! 5.100.49
Shoop da Whoop!
2 rooms
BLLLARRRRGGG! Fires a laser from Isaac's mouth. 2
The D6 5.100.105
The D6
6 rooms
Reroll your destiny Re-rolls all items in the current room into other items, depending on the current room's Item Pool. 4
Undefined 5.100.324
Undefined
6 rooms
Undefined Teleports Isaac to the Secret RoomSecret Room, Super Secret RoomSuper Secret Room, Treasure RoomTreasure Room, or I AM ERRORI AM ERROR. 2
Yum Heart 5.100.45
Yum Heart
4 rooms
Reusable regeneration Restores one full Red HeartRed Heart. 1

Passive[ | ]

Name ID Icon Quote Description (in Repentance) Quality
Abaddon 5.100.230 Abaddon Evil + DMG up + fear shot (except in Repentance) +1.5 damage, +0.2 speed. Removes all Red Heart containers, grants six Black HeartBlack Hearts, and adds a chance to shoot fear tears.
(in Repentance) +1.5 damage, +0.2 speed. Grants two Black HeartBlack Hearts, converts all Red Heart Containers into Black Hearts, and adds a chance to shoot fear tears.
3
Anemic 5.100.214 Anemic Toxic blood After Isaac is damaged, a trail of red creep will be left behind him until he leaves the current room. (except in Repentance) +5 range. (in Repentance) +1.5 range. 1
BFFS! 5.100.247 BFFS! Your friends rule! Increases the size and effectiveness of most familiars. 2
Blood Bag 5.100.119 Blood Bag HP up Grants one filled Red Heart container, restores 4 Red HeartRed Hearts, and increases speed by 0.3. 2
Blood Clot 5.100.254 Blood Clot DMG + range up (except in Repentance)Tears fired from the left eye have +1 flat damage, +5 range, and +0.5 tear falling speed.
(in Repentance)Tears fired from the left eye have +1 flat damage and +2.75 range.
2
Bloody Lust 5.100.157 Bloody Lust RAGE! Increases Isaac's damage whenever he takes damage, up to six times. The bonus resets when entering a new floor. 2
Brimstone 5.100.118 Brimstone Blood laser barrage Tears are replaced by a laser beam that pierces through all enemies and obstacles in its path and deals high damage. Can only be fired after a short charge-up period. 4
Champion Belt 5.100.208 Champion Belt DMG + challenge up +1 damage. Increases the chance of champion enemies appearing by 15%. 3
Contract From Below 5.100.241 Contract From Below Wealth... but at what cost? Doubles the number of most room clear awards, but reduces the overall chance of getting one by 1/3. 3
Cube of Meat 5.100.73 Cube of Meat Gotta meat 'em all! Creates an orbital familiar. Collecting additional copies gives it the ability to shoot tears, then chase enemies to deal contact damage, then deal even more contact damage. 2
E. Coli 5.100.236 E Turdy touch Enemies that touch Isaac are transformed into PoopPoop. 1
Harlequin Baby 5.100.167 Harlequin Baby Double shot buddy Spawns a familiar that follows Isaac around and fires two tears at once in a V-pattern. 1
Isaac's Heart 5.100.276 Isaac's Heart Protect it Isaac himself is now immune to all damage, and a heart familiar follows him. If the heart is hurt, Isaac is hurt. (in Repentance) The heart charges up as Isaac shoots, firing 8 blood shots, knocking back enemies, and leaving a puddle of creep when released. 0
Little C.H.A.D. 5.100.96 Little C.H.A.D. Gives kisses Spawns a familiar who drops a Half Red HeartHalf Red Heart every 3 rooms. 2
Lord of the Pit 5.100.82 Lord of the Pit Demon wings Grants flight and +0.3 speed. 3
Magic Mushroom 5.100.12 Magic Mushroom All stats up! Makes Isaac bigger. Adds one Red Heart Container, +0.3 Damage, x1.5 damage multiplier, (except in Repentance) +5.25 / (in Repentance) +2.5 Range, and +0.3 Speed, and restores all Health. 4
Magic Scab 5.100.253 Magic Scab HP + luck up Grants one full Red Heart container, +1 luck. (in Repentance) Heals 1 additional Red HeartRed Heart. 2
Magneto 5.100.53 Magneto Item snatcher Pulls pickups towards Isaac. 1
MEAT! 5.100.193 MEAT! DMG + HP up Grants one full Red Heart container, +0.3 damage. (in Repentance) Heals 1 additional Red HeartRed Heart 2
Missing Page 2 5.100.262 Missing Page 2 Evil up. Your enemies will pay! Grants one Black HeartBlack Heart. Upon taking damage that reduces Isaac's health to one heart or less, deals damage to all enemies in the room. (in Repentance) Increases the damage of Black HeartBlack Hearts and Collectible The Necronomicon iconThe Necronomicon-like effects by 40. 0
Mom's Contacts 5.100.110 Mom's Contacts Freeze effect Adds a chance to shoot petrifying tears, which stop enemies in place and prevent them from moving or attacking. (except in Repentance) +0.25 range. (in Repentance) +1.5 range. 3
Mom's Heels 5.100.30 Mom's Heels Range up (except in Repentance) +5.25 range, +0.5 tear falling speed.
(in Repentance) +2.5 range, enemies that touch Isaac take 12 damage.
1
Mom's Lipstick 5.100.31 Mom's Lipstick Range up (except in Repentance)+5.25 range, +0.5 tear falling speed.
(in Repentance) +3.75 range. Spawns a Red HeartHeart on pickup.
1
Pentagram 5.100.51 Pentagram DMG up +1 damage, increases Devil RoomDevil Room / Angel RoomAngel Room chance by 10%. 3
Proptosis 5.100.261 Proptosis Short range mega tears Tears start out massive with high damage, and then shrink down and become weaker over a short range. 3
Sister Maggy 5.100.67 Sister Maggy Friends 'till the end (except in Repentance) Spawns a familiar that follows Isaac around shooting tears that deal 3.5 damage.
(in Repentance) Spawns a familiar that follows Isaac around shooting tears that deal 6 damage.
1
Steam Sale 5.100.64 Steam Sale 50% off Reduces all Shop prices by 50%, rounded down to 7 coins for an item, rounded up to 2-3 coins for a pickup. 2
Stem Cells 5.100.176 Stem Cells HP + shot speed up Grants one full Red Heart container and +0.16 shot speed. (in Repentance) Heals 1 additional Red HeartRed Heart 1
The Body 5.100.334 The Body I feel all Adds 3 Red Heart Containers. 3
The Compass 5.100.21 The Compass The end is near Reveals the locations and types of all special rooms on the map, except Secret RoomSecret Rooms and Super Secret RoomSuper Secret Rooms. 2
The Mark 5.100.79 The Mark DMG + speed up (except in Repentance) Grants one Soul HeartSoul Heart, +1 damage, and +0.2 speed.
(in Repentance) Grants one Black HeartBlack Heart, +1 damage, and +0.2 speed.
3
The Virus 5.100.13 The Virus Poison touch + speed up Isaac poisons enemies on contact. (except in Repentance) -0.1 speed. (in Repentance) +0.2 speed. (in Afterbirth and Afterbirth †) Poisoned enemies have a chance to drop a black heart when killed. 2
[edit]

Active[ | ]

Name ID Icon Quote Description (in Repentance) Quality
Best Friend 5.100.136
Best Friend
3 rooms
Friends 'till the end Spawns a decoy Isaac that explodes after 5 seconds. Enemies will always target the decoy and ignore Isaac. 1

Passive[ | ]

Name ID Icon Quote Description (in Repentance) Quality
3 Dollar Bill 5.100.191 3 Dollar Bill Rainbow tears (in Rebirth) Gives Isaac a random tear effect every room.
(except in Rebirth) Gives Isaac a random tear effect every few seconds.
2
Ball of Bandages 5.100.207 Ball of Bandages Gotta lick 'em all! Creates an orbital familiar. Collecting additional copies gives it the ability to shoot Charm tears, then chase enemies to deal contact damage, then deal even more contact damage. 2
Bum Friend 5.100.144 Bum Friend He's greedy Spawns a familiar that picks up Pennycoins for himself, giving random pickups in return. (in Repentance) Can spawn Items from the Beggar Item Pool. 1
Dr. Fetus 5.100.52 Dr ??? Tears are replaced by BombBombs that benefit from bomb-enhancing effects and slide for a fixed time after being fired. 4
Guardian Angel 5.100.112 Guardian Angel Extra protection Spawns an orbital familiar that blocks enemy shots, deals (except in Repentance) 105 /(in Repentance) 52.5 damage per second to enemies, and increases the speed of all orbital familiars. 2
Guppy's Collar 5.100.212 Guppy's Collar Eternal life? Grants a permanent 50% chance to respawn with 1/2 of a Red HeartRed Heart after death. 1
Lucky Foot 5.100.46 Lucky Foot Luck up +1 luck. Improves Isaac's chances at various random events (independent from the luck stat). (in Repentance) Converts all bad pills into good pills, without identifying them. 2
Maggy's Bow 5.100.312 Maggy's Bow HP up + you feel healthy Gives one Red Heart Container and doubles the healing provided by Red HeartRed Hearts. (in Repentance) Also heals 1 Red Heart when obtained. 2
Mom's Underwear 5.100.29 Mom's Underwear Range up (except in Repentance) +5.25 range, +0.5 tear falling speed.
(in Repentance) +2.5 range. Spawns 3-6 Blue Flies on pickup.
1
Monstro's Lung 5.100.229 Monstro's Lung Charged burst attack Replaces normal tears with a charged shot that fires 14 tears in the same fashion as Boss Monstro ingameMonstro. 2
Pageant Boy 5.100.141 Pageant Boy Ultimate grand supreme Spawns seven random coins around Isaac. 0
Piggy Bank 5.100.227 Piggy Bank My life savings Gives 3 PennyPennies on pick-up. Every time Isaac is damaged, he will drop one or two additional pennies. 1
Punching Bag 5.100.281 Punching Bag Scape goat Spawns a MulliganMulligan familiar that wanders randomly. Enemies will attack the Mulligan if it's closer. 1
Rosary 5.100.72 Rosary Tears + faith up Grants 3 Soul HeartSoul Hearts. Causes Collectible The Bible iconThe Bible to appear in any item pool. (in Repentance) +0.5 tears. 2
Sacred Heart 5.100.182 Sacred Heart Homing shots + DMG up (except in Repentance) Adds a Red Heart Container. Grants homing tears, a x2.3 Damage multiplier, +1 flat Damage, -0.4 Tears, -0.25 Shot Speed, and +4.125 Range.
(in Repentance) Adds a Red Heart Container. Grants homing tears, a x2.3 Damage multiplier, +1 flat Damage, -0.4 Tears, and -0.25 Shot Speed.
4
Super Bandage 5.100.92 Super Bandage +2 hearts Grants one full Red Heart container and 2 Soul HeartSoul Hearts. 2
The Parasite 5.100.104 The Parasite Split shot Isaac's tears split in two when they hit something. 3
[edit]

Active[ | ]

Name ID Icon Quote Description (in Repentance) Quality
D10 5.100.285
D10
2 rooms
Reroll enemies (except in Repentance) Re-rolls all monsters in the room.
(in Repentance) Replaces all monsters in the room with weaker monsters.
1
Mom's Bottle of Pills 5.100.102
Mom's Bottle of Pills
6 rooms
Reusable pill generator On use, gives Isaac a random pill. 1

Passive[ | ]

Name ID Icon Quote Description (in Repentance) Quality
Fire Mind 5.100.257 Fire Mind Flaming tears Grants flaming tears that deal burning damage over time. Tears have a chance to explode on impact with an enemy, which creates a fire at the location of the explosion. 2
Infestation 2 5.100.234 Infestation 2 Infestation shot Spawns allied Blue Spiders from killed enemies. 3
Mom's Wig 5.100.217 Mom's Wig You feel itchy... Adds a chance to spawn Blue Spiders when firing tears. Restores 1 Red HeartRed Heart. 2
Pyromaniac 5.100.223 Pyromaniac It hurts so good +5 bombs +5 bombs. Grants immunity to explosion damage and causes explosions to heal Isaac. (in Repentance) Also grants immunity to fire. 4
Rubber Cement 5.100.221 Rubber Cement Bouncing tears Tears bounce off walls, enemies, and environmental objects. 3
[edit]

Active[ | ]

Name ID Icon Quote Description (in Repentance) Quality
Lemon Mishap 5.100.56
Lemon Mishap
2 rooms
Oops... Creates a tiny pool of yellow creep, damaging enemies that cross it. 0
Magic Fingers 5.100.295
Magic Fingers
Unlimited
Pay to win Uses 1 PennyPenny to deal damage to all enemies in the room. 1
Prayer Card 5.100.146
Prayer Card
6 rooms
Reusable eternity Gives an Eternal HeartEternal Heart per use. 3
Telepathy For Dummies 5.100.192
Telepathy For Dummies
2 rooms
Temporary psychic shot Gives homing tears for the current room. (in Repentance) Also gives +3 range. 1

Passive[ | ]

Name ID Icon Quote Description (in Repentance) Quality
Experimental Treatment 5.100.240 Experimental Treatment Some stats up, some stats down (in Rebirth and Afterbirth) Randomly increases and decreases some of Isaac's stats.
(in Afterbirth † and Repentance) Increases four random stats and decreases the other two.
1
Infestation 5.100.148 Infestation Fly revenge (except in Repentance) 1-3 Blue Flies randomly spawn every time Isaac gets hit.
(in Repentance) 2-6 Blue Flies
0
Key Piece 1 5.100.238 Key Piece 1 ??? Combined with Collectible Key Piece 2 iconKey Piece 2, unlocks the golden gate in the starting room of ChestChest and Dark RoomDark Room to fight Mega Satan Head ingameMega Satan. 0
Key Piece 2 5.100.239 Key Piece 2 ??? Combined with Collectible Key Piece 1 iconKey Piece 1, unlocks the golden gate in the starting room of ChestChest and Dark RoomDark Room to fight Mega Satan Head ingameMega Satan. 0
Little Chubby 5.100.88 Little Chubby Attack buddy Spawns a ChargerCharger familiar that charges forward and deals contact damage to any enemies in its path. 2
Midas' Touch 5.100.202 Midas' Touch Golden touch Enemies that touch Isaac are temporarily petrified and turn to gold. Any enemy killed while in this state will drop PennyPennies. 2
Mitre 5.100.173 Mitre Blessing of purity Grants a chance of converting any Red HeartRed Heart pickups into Soul HeartSoul Hearts instead. 3
Mom's Key 5.100.199 Mom's Key Better chest loot +2 keys Adds 2 keys. ChestChests will drop additional pickups. 3
Mom's Perfume 5.100.228 Mom's Perfume Fear shot + tears up Adds a chance to shoot fear tears. (except in Repentance) Decreases tear delay by 1. (in Repentance) +0.5 fire rate. 2
Number One 5.100.6 Number One Tears up + range down Grants +1.5 tears, but severely reduces range. 2
Smart Fly 5.100.264 Smart Fly Revenge fly Spawns an orbital familiar that blocks enemy shots. Upon taking damage, the familiar will pursue enemies for the rest of the room, dealing 22.5 damage per second. 2
Soy Milk 5.100.330 Soy Milk DMG down + tears way up Tears are smaller and do much less damage, but fire in very rapid succession. 2
The Halo 5.100.101 The Halo All stats up (except in Repentance) Grants one full Red Heart container, +0.3 damage, +0.2 tears, +0.25 range, +0.3 speed, and +0.5 tear falling speed.
(in Repentance) Grants one full Red Heart container, +0.3 damage, +0.2 tears, +1.5 range, and +0.3 speed. Heals 1 additional Red HeartRed Heart.
2
The Mind 5.100.333 The Mind I know all Reveals the entire map, including all special rooms and Secret RoomSecret Rooms. 3
The Wafer 5.100.108 The Wafer Damage resistance Most sources of damage that would cause more than one-half heart of damage are reduced to one-half heart instead. 4
Thunder Thighs 5.100.314 Thunder Thighs HP up + speed down + you feel stompy Destroys rocks upon contact with Isaac. Adds one Red Heart container and lowers Speed. 1
Tooth Picks 5.100.183 Tooth Picks Tears + shot speed up +0.7 tears, +0.16 shot speed. 3
(except in Rebirth) More Options 5.100.414 More Options There's options Two item pedestals are presented in every Treasure RoomTreasure Room. Only one can be taken; the other will disappear. 3
[edit]

Active[ | ]

Name ID Icon Quote Description (in Repentance) Quality
Blood Rights 5.100.186
Blood Rights
Unlimited
Mass enemy damage at a cost Upon use, takes a full heart of health and deals 40 damage to all enemies in the room. (in Repentance) Repeated uses in the same room only take half a heart. 0
Dad's Key 5.100.175
Dad's Key
2 rooms
Opens all doors... Upon activation, opens all doors in the current room in almost all circumstances, including doors which require a KeyKey to open, entrances to Secret RoomSecret Rooms, and the door to Mega Satan Head ingameMega Satan. 2
Dead Sea Scrolls 5.100.124
Dead Sea Scrolls
2 rooms
It's a mystery Triggers the effect of a random activated item from a list of possible options (not every activated item is included). 1
Deck of Cards 5.100.85
Deck of Cards
6 rooms
Reusable card generator Gives Isaac a random card. 2
Tammy's Head 5.100.38
Tammy's Head
1 room
Reusable tear burst Shoots 10 tears in a circle around Isaac, which retain the damage, range, shot speed, and special effects (such as poison) of Isaac's tears. Tears from this item have a +25 flat damage bonus. 2
The Bean 5.100.111
The Bean
1 room
Toot on command Isaac farts, poisoning any enemy in close range. 0
The Bible 5.100.33
The Bible
4 rooms
Temporary flight On use, Isaac gains flight for the current room. Instantly kills Boss Mom ingameMom, Boss Mom's Heart ingameMom's Heart, and Boss It Lives ingameIt Lives when activated, but kills Isaac when used on Boss Satan ingameSatan. 1
The Hourglass 5.100.66
The Hourglass
2 rooms
Temporary enemy slowdown All enemies in the room are slowed for 8 seconds. 1
The Necronomicon 5.100.35
The Necronomicon
4 rooms
Mass room damage Deals 40 damage to every enemy in the room. 1
The Poop 5.100.36
The Poop
1 room
Plop! Spawns a pile of PoopPoop where Isaac is standing and knocks back nearby enemies. May yield pickups like regular poop. 0

Passive[ | ]

Name ID Icon Quote Description (in Repentance) Quality
A Snack 5.100.346 A Snack HP up Grants one full Red Heart container. (in Repentance) Heals 1 additional Red HeartRed Heart. 1
Big Fan 5.100.279 Big Fan Fat protector Spawns a large orbital familiar that blocks enemy shots and deals 30 damage per second to enemies. 2
Blood of the Martyr 5.100.7 Blood of the Martyr DMG up +1 damage. Isaac shoots blood tears. 3
Box 5.100.198 Box Stuff Spawns various pickups: 1 Pennycoin, 1 KeyKey, 1 BombBomb, 1 Red HeartHeart, 1 card/rune, 1 pill and 1 trinket. 0
Butt Bombs 5.100.209 Butt Bombs Toxic blast +5 bombs +5 BombBombs. Bombs now cloud up the screen, briefly damaging and confusing all enemies. 2
Chocolate Milk 5.100.69 Chocolate Milk Charge shots Grants charged tears that deal greater damage when fully charged. 3
Cricket's Body 5.100.224 Cricket's Body Bursting shots + tears up When tears hit an object or deplete their range, they spawn 4 smaller tears, whose range and damage scale with Isaac's. (except in Repentance) Grants -1 tear delay and reduces range. (in Repentance) Grants +0.5 fire rate and reduces range. 3
Cricket's Head 5.100.4 Cricket's Head DMG up Increases Damage by 0.5, and increases damage multiplier by x1.5. 4
Dead Onion 5.100.336 Dead Onion Toxic aura tears Grants piercing and spectral tears. Increases tear size (without increasing damage) while greatly reducing range and shot speed. 3
Dessert 5.100.24 Dessert HP up Grants one full Red Heart container. (in Repentance) Heals 1 additional Red HeartRed Heart. 1
Dinner 5.100.23 Dinner HP up Grants one full Red Heart container. (in Repentance) Heals 1 additional Red HeartRed Heart. 1
Fanny Pack 5.100.204 Fanny Pack Filled with goodies Has a chance to drop a random pickup when Isaac takes damage. 1
Goat Head 5.100.215 Goat Head He accepts your offering A Devil RoomDevil Room / Angel RoomAngel Room will always spawn after every boss fight, excluding the first floor and floors after Chapter 4. 3
Guppy's Hairball 5.100.187 Guppy's Hairball Swing it Spawns a familiar that loosely follows behind Isaac, which blocks shots can be swung like a flail to damage enemies. Grows bigger by killing enemies. 1
Holy Grail 5.100.184 Holy Grail Flight + HP up Grants flight and one Red Heart container. (in Repentance) Heals 1 additional Red HeartRed Heart. 3
Humbleing Bundle 5.100.203 Humbleing Bundle 1+1 free 4Evar Transforms BombBombs, KeyKeys, PennyPennies, and Red HeartRed Hearts into their respective Double versions. (in Repentance) This will occur 50% of the time. 3
Latch Key 5.100.343 Latch Key Luck up Grants 1 Soul HeartSoul Heart and +1 luck. Spawns 2 KeyKeys. 1
Lunch 5.100.22 Lunch HP up Grants one full Red Heart container. (in Repentance) Heals 1 additional Red HeartRed Heart. 1
Mom's Coin Purse 5.100.195 Mom's Coin Purse What's all this...? Spawns 4 random pills near Isaac. 1
Odd Mushroom 5.100.121 Odd Mushroom HP + DMG up, speed down (except in Repentance) Grants one empty Heart container, +0.3 damage, +0.25 range, +0.5 tear falling speed, and -0.1 speed.
(in Repentance) Grants one full Heart container, +1 damage, +1.5 range, and -0.2 speed
2
Odd Mushroom 5.100.120 Odd Mushroom Tears + speed up, DMG down +1.7 tears, +0.3 speed, slightly reduces damage. 2
Ouija Board 5.100.115 Ouija Board Spectral tears + tears up Grants spectral tears that travel through obstacles (but not enemies). (in Repentance) +0.5 tears. 2
Raw Liver 5.100.16 Raw Liver HP up Grants 2 Red Heart containers and completely restores health. 2
Rotten Meat 5.100.26 Rotten Meat HP up Grants one full Red Heart container. (in Repentance) Heals 1 additional Red HeartRed Heart. 1
Scapular 5.100.142 Scapular Pray for a miracle Once per room, when Isaac is reduced to his last half heart, he is granted one Soul HeartSoul Heart. 2
Squeezy 5.100.196 Squeezy Tears up Increases tears by 0.4, spawns 2 Soul HeartSoul Hearts. 3
Starter Deck 5.100.251 Starter Deck Extra card room Isaac can hold 2 cards at once and all pills are replaced by cards. 2
Stigmata 5.100.138 Stigmata DMG + HP up +0.3 damage, grants one full Red Heart container. (in Repentance) Heals 1 additional Red HeartRed Heart. 2
The Belt 5.100.28 The Belt Speed up Increases speed by 0.3. 1
The Ladder 5.100.60 The Ladder Building bridges Allows Isaac to walk across gaps one square across by automatically placing a ladder between the two walkable sections. 1
Transcendence 5.100.20 Transcendence We all float down here... Grants flight. 3
Treasure Map 5.100.54 Treasure Map Full visible map Reveals the map of each floor. It does not identify special rooms and does not reveal the locations of Secret RoomSecret Rooms / Super Secret RoomSuper Secret Rooms. 2
Wooden Spoon 5.100.27 Wooden Spoon Speed up Increases speed by 0.3. 1
[edit]

Active[ | ]

Name ID Icon Quote Description (in Repentance) Quality
Bob's Rotten Head 5.100.42
Bob's Rotten Head
2 rooms
Reusable ranged bomb Upon use, Isaac holds a poison BombBomb which can be thrown in the cardinal directions and explodes on impact. 1
D4 5.100.284
D4
6 rooms
Reroll into something else Rerolls all of Isaac's passive items. 2

Passive[ | ]

Name ID Icon Quote Description (in Repentance) Quality
1up! 5.100.11 1up! Extra life Gives Isaac an extra life. Upon death, he will respawn in the previous room with full health, after which 1up! will disappear. 2
A Dollar 5.100.18 A Dollar $$$ Gives Isaac 100 PennyPennies. 3
Abel 5.100.188 Abel Mirrored buddy (in Rebirth) Spawns a familiar that mirrors Isaac's movements and shoots in the opposite direction.
(except in Rebirth) Spawns a familiar that mirrors Isaac's movements and shoots towards him.
0
Bob's Brain 5.100.273 Bob's Brain Explosive thoughts Spawns a familiar that charges forward when shooting tears and explodes upon contact with an enemy, damaging and poisoning them. The familiar respawns after a few seconds. 1
Bob's Curse 5.100.140 Bob's Curse +5 poison bombs +5 BombBombs. Grants Isaac's bombs a poison effect. (in Repentance) They also leave a lingering poison cloud, and Isaac becomes immune to poison. 1
Chemical Peel 5.100.154 Chemical Peel DMG up Tears fired from the left eye have +2 flat damage. 2
Gnawed Leaf 5.100.210 Gnawed Leaf Unbreakable After standing still and not shooting for a short time, Isaac turns invincible until he moves or shoots. 1
Mutant Spider 5.100.153 Mutant Spider Quad shot Grants quadruple shot but decreases Tears. 3
Mysterious Liquid 5.100.317 Mysterious Liquid Toxic splash damage Tears leave a small, short lasting pool of creep on impact or when their range is depleted. 3
Roid Rage 5.100.14 Roid Rage Speed and range up (except in Repentance) +0.6 speed, +5.25 range, +0.5 tear falling speed.
(in Repentance) +0.3 speed, +2.5 range
2
Rotten Baby 5.100.268 Rotten Baby Infested friend Spawns a familiar that spawns a Blue Fly when Isaac shoots. It can only have one Fly at a time. 3
The Common Cold 5.100.103 The Common Cold Poison damage Adds a chance to shoot poison tears, dealing damage over time when inflicted. 1
The Sad Onion 5.100.1 The Sad Onion Tears up Increases tears by 0.7. 3
[edit]

Active[ | ]

Name ID Icon Quote Description (in Repentance) Quality
Converter 5.100.296
Converter
3 rooms
Convert your soul (except in Repentance) Converts two Soul HeartSoul Hearts or Black HeartBlack Hearts into one filled Red HeartRed Heart Container.
(in Repentance) Converts one Soul HeartSoul Heart or Black HeartBlack Heart into one filled Red HeartRed Heart Container.
2
Isaac's Tears 5.100.323
Isaac's Tears
6 rooms
Collected tears Fires 8 tears around Isaac, which retain the damage, range, shot speed, and special tear effects of his tears. Each tear shot by Isaac increases item charge by one. (in Repentance) Tears from this item have a +5 flat damage bonus. 1
Monster Manual 5.100.123
Monster Manual
6 rooms
Temporary buddy generator (except in Repentance) Spawns a familiar from a specific selection for the current room.
(in Repentance) Spawns a familiar from a specific selection for the current floor.
1
Pandora's Box 5.100.297
Pandora's Box
One time use
? ? Upon use, spawns specific pickups or items depending on the floor it is used on. Disappears after use. 2
Teleport! 5.100.44
Teleport!
2 rooms
Teleport! Teleports Isaac to a random room on the current floor. 0
The Boomerang 5.100.338
The Boomerang
2 seconds
It will never leave you Throws a boomerang which retrieves pickups, as well as damages and petrifies enemies hit for 2 seconds. 1
The Candle 5.100.164
The Candle
4 seconds
Reusable flames Throws out a flame that damages everything in its path, diminishing in size as it travels. 2

Passive[ | ]

Name ID Icon Quote Description (in Repentance) Quality
???'s Only Friend 5.100.320 ???'s Only Friend Controlled friend Spawns a controllable familiar that deals 37.5 damage per second on touch. It can be moved using the shooting directional keys 1
Anti-Gravity 5.100.222 Anti-Gravity Anti-gravity tears + tears up Tears float in position until firing ceases, after which they will fly off in the direction they were shot in. (except in Repentance) -2 Tear Delay. (in Repentance) +1 Fire Rate. 2
Aquarius 5.100.308 Aquarius Trail of tears A trail of blue creep is left behind Isaac, which damages enemies. (in Repentance) The creep inherits most of Isaac's tear effects, like homing, etc. 2
Aries 5.100.300 Aries Ramming speed +0.25 Speed. Running into enemies while at a high speed will deal damage. (in Repentance) Prevents Isaac from taking contact damage while moving at high speed. 2
Blue Cap 5.100.342 Blue Cap HP + tears up + shot speed down Gives one full Red Heart container, +0.7 tears, and -0.16 shot speed. (in Repentance) Heals 1 additional Red HeartRed Heart. 3
Blue Map 5.100.246 Blue Map Secrets Reveals the locations of Secret RoomSecret Rooms and Super Secret RoomSuper Secret Rooms on the map. 2
Broken Watch 5.100.337 Broken Watch I think it's broken Slows all enemies in every fourth newly-discovered room, with a small chance to speed them up instead. 1
Brother Bobby 5.100.8 Brother Bobby Friends 'till the end Spawns a familiar that follows Isaac around shooting tears that deal 3.5 damage. (in Repentance) He shoots more frequently than most familiars. 1
Cancer 5.100.301 Cancer HP up + you feel protected Adds 3 Soul HeartSoul Hearts. Grants Collectible The Wafer iconThe Wafer effect for the current room after taking damage. 3
Capricorn 5.100.307 Capricorn All stats up (except in Repentance) Adds 1 Red Heart Container, gives +0.5 Damage, +0.1 Speed, +1.5 Range, and -1.0 Tear Delay, and gives 1 BombBomb, PennyPenny, and KeyKey.
(in Repentance) Adds 1 Red Heart Container, gives +0.5 Damage, +0.1 Speed, +0.75 Range, and +0.5 Fire Rate, and gives 1 BombBomb, PennyPenny, and KeyKey.
3
Fate 5.100.179 Fate Flight eternal Grants flight and one Eternal HeartEternal Heart. 3
Forever alone 5.100.128 Forever alone Attack fly Spawns an attack fly that orbits a long distance from Isaac, dealing 30 damage per second. 1
Gemini 5.100.318 Gemini Conjoined friend Spawns a conjoined familiar which chases enemies close to Isaac, dealing ~6.43 damage per second. 1
Hive Mind 5.100.248 Hive Mind Giant spiders and flies Increases the size of Blue Spiders and Blue Flies and doubles the amount of damage they deal. (in Repentance) Also increases the effectiveness of fly and spider familiars. 2
Holy Mantle 5.100.313 Holy Mantle Holy shield Grants a shield that negates the first instance of damage taken, once per room. Does not apply to or negate self-damage (Blood Donation MachineBlood Donation Machines, etc). 4
Holy Water 5.100.178 Holy Water Splash! (except in Repentance) Spawns a bottle familiar that breaks when Isaac takes damage, leaving a puddle of blue creep.
(in Repentance) A bottle familiar that flies forward when Isaac shoots. It breaks upon hitting an enemy, leaving a puddle of blue creep that petrifies enemies.
3
Leo 5.100.302 Leo Stompy Isaac can destroy rocks by walking into them. 1
Libra 5.100.304 Libra You feel balanced Gives 6 PennyCoins, 6 BombBombs, and 6 KeyKeys and balances out all attributes. 1
Mini Mush 5.100.71 Mini Mush Speed + range up Decreases Isaac's size, making him less likely to be hit. (except in Repentance)+0.3 speed, +1.5 tear falling speed, -4.25 range (effective range is increased). (in Repentance) +0.3 speed, +2.5 range. 2
Pisces 5.100.309 Pisces Tears up + knock-back shots (except in Repentance) -1 Tear Delay, adds knock-back shots and increases tear size.
(in Repentance) +0.5 Fire Rate, adds knock-back shots and increases tear size.
2
Sagittarius 5.100.306 Sagittarius Piercing shots + speed up Increases speed by +0.2 and grants piercing tears. 3
Scorpio 5.100.305 Scorpio Poison tears Grants poison tears, which deal damage over time when inflicted. 3
Sissy Longlegs 5.100.280 Sissy Longlegs She loves you Spawns a familiar that wanders randomly, occasionally spawning Blue Spiders. (in Repentance) Briefly charms enemies on contact. 1
Stop Watch 5.100.232 Stop Watch Let's slow this down a bit... (in Rebirth)+0.3 speed. Automatically inflicts slow to all enemies in every room.
(in Afterbirth and Afterbirth †)+0.3 speed. Upon taking damage, inflicts slow to all enemies for the current room.
(in Repentance)+0.3 speed. Slows all enemies in every room to 80% speed.
4
Taurus 5.100.299 Taurus Speed down + rage is building -0.3 Speed. Isaac builds speed while in a room with enemies. At max speed, he gains the Collectible My Little Unicorn iconMy Little Unicorn effect for 5 seconds. 1
The Mulligan 5.100.151 The Mulligan They grow inside Tears have a 1/6 chance of spawning allied Blue Flies when they hit an enemy. 3
The Relic 5.100.98 The Relic Soul generator Spawns a cross familiar that drops a Soul HeartSoul Heart after clearing enough rooms. 3
The Soul 5.100.335 The Soul I am all Grants two Soul HeartSoul Hearts. Isaac gains a pulsing aura that repels enemies and projectiles. 3
Trinity Shield 5.100.243 Trinity Shield You feel guarded Isaac gains a shield that protects him from enemy shots. It aims in the direction Isaac fires from. 2
Virgo 5.100.303 Virgo You feel refreshed and protected Adds a chance to give a shield that nullifies all incoming damage for 10 seconds upon taking damage. Also converts bad pills into good pills. 2
[edit]

Active[ | ]

Name ID Icon Quote Description (in Repentance) Quality
Book of Revelations 5.100.78
Book of Revelations
6 rooms
Reusable soul protection Increases the chance of a Devil RoomDevil Room / Angel RoomAngel Room appearing while held. On use, gives one Soul HeartSoul Heart, and replaces the boss of the current floor with a Harbinger if possible. 3

Passive[ | ]

Name ID Icon Quote Description (in Repentance) Quality
Growth Hormones 5.100.70 Growth Hormones Speed + DMG up (except in Repentance) +1 damage, +0.4 speed.
(in Repentance) +1 damage, +0.2 speed.
3
Infamy 5.100.242 Infamy Blocks damage... sometimes Gives Isaac a 50% chance to block projectiles coming from any direction. 2
Ipecac 5.100.149 Ipecac Explosive shots Replaces tears with explosive and poisoning projectiles fired in an arc from the mouth. 4
Jesus Juice 5.100.197 Jesus Juice Damage + range up (except in Repentance) +0.5 damage, +0.25 range, +0.5 tear falling speed.
(in Repentance) +0.5 damage, +1.5 range.
2
Mom's Purse 5.100.139 Mom's Purse More trinket room Allows Isaac to hold one additional trinket. (in Repentance) Drops a random trinket. 2
Mystery Sack 5.100.271 Mystery Sack ? Spawns a familiar that drops a Heart, coin, BombBomb, or KeyKey every 5-6 rooms. 2
Placenta 5.100.218 Placenta Regeneration + HP up Grants one full Red Heart container, and a chance to regenerate a Half Red HeartHalf Red Heart of health every minute of gameplay. 2
Sack of Pennies 5.100.94 Sack of Pennies Gives money Spawns a familiar that drops a Pennycoin every 2 rooms. 1
[edit]

Passive[ | ]

Name ID Icon Quote Description (in Repentance) Quality
Godhead 5.100.331 Godhead God tears (except in Repentance) Grants homing tears with a damaging halo. +0.5 Damage, -0.3 Tears -0.3 Shot Speed, +0.8 Tear Falling Speed, and +1.2 Range.
(in Repentance) Grants homing tears with a damaging halo. +0.5 Damage, -0.3 Tears, and -0.3 Shot Speed.
4
Little Baggy 5.100.252 Little Baggy Extra pill room Isaac can hold 2 pills at once and all cards and runes are replaced by pills. 0
Missing No. 5.100.258 Missing No. Syntax error Randomizes all passive items and stats upon pickup and at the start of each succeeding floor. 0
Mongo Baby 5.100.322 Mongo Baby Mongo friend Spawns a familiar that copies the tears of Isaac's other familiars. 2
Rainbow Baby 5.100.174 Rainbow Baby Random buddy Spawns a familiar that follows Isaac around and fires tears with random effects. 1
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