Vis are enemies most commonly found in The Depths. They are headless like Hoppers, and have their entire torso cut open. When Isaac lines up with the Vis in a cardinal direction, it will fire a brimstone beam in that direction.
Variations
Double Vis
Added in the Wrath of the Lamb DLC for the original Binding of Isaac, the Double Vis appears similar to the normal Vis, but has blood around its openings and a vertical gash in its back. They function identically to regular Vis, but they also fire a blood beam from behind.
Chubber
Chubbers, like Double Vis, were added in the Wrath of the Lamb DLC for the original The Binding of Isaac. They look identical to Vis, but have a maggot in their head. Instead of shooting the blood beam that regular Vis and Double Vis have, Chubber shoots a Charger, similar to the Little Chubby Familiar, which can go through rocks. They can be found in the same locations as Double Vis; however, they are less common. The Charger it shoots does a full heart of damage, will destroy any tears in its way and has a limited range. Once the Charger has reached this range, it will return to the Chubber.
If the Chubber is killed before the Charger has returned to its body, he will still return to the last location and will simply disappear upon touching it. The Charger can still damage Isaac during this time. Killing the Charger with a Chaos Card will not transform the Chubber into a normal Vis. If the Charger is charmed when being fired it will not deal damage to the Chubber when returning.
Scarred Double Vis
The Scarred Double Vis behaves identically to the normal Vis, but fires blood beams in all four cardinal directions.
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Notes
- The Vis and its variations might be the most useful and powerful enemies when they are charmed, spawned by
Friendly Ball, or Poke Go, since its Brimstone Laser is very powerful and can very quickly kill enemies and even bosses.
Trivia
- In the original Binding Of Isaac, if a Vis or a Double Vis was a champion, its Brimstone would be colored.
- Gluttony and Super Gluttony are headed Vis.
- The designs are based off of the Sisters Vis, which originated from Gish, one of Edmund McMillen's other games.
Bugs
 Bug!
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If a Vis (or any of its variants) is  stunned, scared, or shrunken, it will still attack the player while running away from Isaac.
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 The Binding of Isaac: Rebirth
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